Ontology: Cellular Component (GO:0005635)

Definition: The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term nuclear envelope (61 genes) or to its variants containing one or more qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	colocalizes_with: nuclear envelope	1
	nuclear envelope	43
High-throughput (download data)	nuclear envelope	15
Computational (download data)	nuclear envelope	8

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term nuclear envelope or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

nuclear envelope      61 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
APQ12/YIL040W	IDA: Inferred from Direct Assay Assigned on 2004-10-05	manually curated	Baker KE, et al.  (2004) The yeast Apq12 protein affects nucleocytoplasmic mRNA transport. RNA 10(9):1352-8	SGD
ASP3-1/YLR155C	IDA: Inferred from Direct Assay Assigned on 2002-05-07	high-throughput	Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19	SGD
BRL1/YHR036W	IDA: Inferred from Direct Assay Assigned on 2005-08-10	manually curated	Saitoh Yh, et al.  (2005) Brl1p -- a novel nuclear envelope protein required for nuclear transport. Traffic 6(6):502-17	SGD
BRR6/YGL247W	IDA: Inferred from Direct Assay Assigned on 2002-08-01	manually curated	de Bruyn Kops A and Guthrie C  (2001) An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport. EMBO J 20(15):4183-93	SGD
CAB5/YDR196C	IDA: Inferred from Direct Assay Assigned on 2004-01-05	high-throughput	Hazbun TR, et al.  (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65	SGD
COS10/YNR075W	IDA: Inferred from Direct Assay Assigned on 2002-05-07	high-throughput	Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19	SGD
COS8/YHL048W	IDA: Inferred from Direct Assay Assigned on 2002-09-20	manually curated	Spode I, et al.  (2002) ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. J Mol Biol 319(2):407-20	SGD
CSE1/YGL238W	IDA: Inferred from Direct Assay Assigned on 2002-08-07	manually curated	Hood JK and Silver PA  (1998) Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae. J Biol Chem 273(52):35142-6	SGD
CSM1/YCR086W	IDA: Inferred from Direct Assay Assigned on 2003-05-12	manually curated	Drees BL, et al.  (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71	SGD
CTS1/YLR286C	IDA: Inferred from Direct Assay Assigned on 2002-05-07	high-throughput	Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19	SGD
GCR1/YPL075W	IDA: Inferred from Direct Assay Assigned on 2009-03-31	manually curated	Menon BB, et al.  (2005) Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Proc Natl Acad Sci U S A 102(16):5749-54	SGD
GCR2/YNL199C	IDA: Inferred from Direct Assay Assigned on 2009-03-31	manually curated	Menon BB, et al.  (2005) Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Proc Natl Acad Sci U S A 102(16):5749-54	SGD
GPI19/YDR437W	IDA: Inferred from Direct Assay Assigned on 2004-01-05	high-throughput	Hazbun TR, et al.  (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65	SGD
HAS1/YMR290C	IDA: Inferred from Direct Assay Assigned on 2002-06-20	manually curated	Rout MP, et al.  (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51	SGD
HEH2/YDR458C	IDA: Inferred from Direct Assay Assigned on 2007-10-02	manually curated	King MC, et al.  (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442(7106):1003-7	SGD
HMG1/YML075C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Koning AJ, et al.  (1996) Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Mol Biol Cell 7(5):769-89	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0178 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
HMG2/YLR450W	IDA: Inferred from Direct Assay Assigned on 2010-06-17	manually curated	Koning AJ, et al.  (1996) Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Mol Biol Cell 7(5):769-89	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0178 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
KAP122/YGL016W	IEA: Inferred from Electronic Annotation with EBI:SL-0178 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
KAP95/YLR347C	IEA: Inferred from Electronic Annotation with EBI:SL-0178 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
LIP1/YMR298W	IDA: Inferred from Direct Assay Assigned on 2004-01-05	high-throughput	Hazbun TR, et al.  (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65	SGD
MLP1/YKR095W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Strambio-de-Castillia C, et al.  (1999) Proteins connecting the nuclear pore complex with the nuclear interior. J Cell Biol 144(5):839-55	SGD
MLP2/YIL149C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Strambio-de-Castillia C, et al.  (1999) Proteins connecting the nuclear pore complex with the nuclear interior. J Cell Biol 144(5):839-55	SGD
MMS21/YEL019C	IDA: Inferred from Direct Assay Assigned on 2005-03-21	manually curated	Zhao X and Blobel G  (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82	SGD
MPS2/YGL075C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Munoz-Centeno MC, et al.  (1999) Saccharomyces cerevisiae MPS2 encodes a membrane protein localized at the spindle pole body and the nuclear envelope. Mol Biol Cell 10(7):2393-406	SGD
MPS3/YJL019W	IDA: Inferred from Direct Assay Assigned on 2008-08-01	manually curated	Conrad MN, et al.  (2007) MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 104(21):8863-8	SGD
NTF2/YER009W	IDA: Inferred from Direct Assay Assigned on 2002-03-07	manually curated	Corbett AH and Silver PA  (1996) The NTF2 gene encodes an essential, highly conserved protein that functions in nuclear transport in vivo. J Biol Chem 271(31):18477-84	SGD
NUD1/YOR373W	IEA: Inferred from Electronic Annotation with EBI:SL-0178 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
NUP49/YGL172W	IDA: Inferred from Direct Assay Assigned on 2002-05-07	high-throughput	Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19	SGD
NUS1/YDL193W	IDA: Inferred from Direct Assay Assigned on 2004-01-05	high-throughput	Hazbun TR, et al.  (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65	SGD
NVJ1/YHR195W	IDA: Inferred from Direct Assay Assigned on 2002-09-27	manually curated	Pan X, et al.  (2000) Nucleus-vacuole junctions in Saccharomyces cerevisiae are formed through the direct interaction of Vac8p with Nvj1p. Mol Biol Cell 11(7):2445-57	SGD

colocalizes_with: nuclear envelope      1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
SLI1/YGR212W	IDA: Inferred from Direct Assay Assigned on 2005-05-05	manually curated	Momoi M, et al.  (2004) SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeast. Biochem J 381(Pt 1):321-8	SGD

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