GO term: nucleus 
Ontology: Cellular Component (GO:0005634)
Definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Synonyms: cell nucleus
View Ontology:
(graph) | 
(text)
Definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Synonyms: cell nucleus
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
nucleus (2090 genes)
or to its variants containing one or more
qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | NOT: nucleus | 1 |
| nucleus | 793 | |
| High-throughput (download data) | nucleus | 725 |
| Computational (download data) | nucleus | 1715 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
nucleus or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| NOT: nucleus 1 gene directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| TOS3/YGL179C | IDA: Inferred from Direct Assay Assigned on 2005-06-09 |
manually curated | Kim MD, et al. (2005) Role of Tos3, a Snf1 protein kinase kinase, during growth of Saccharomyces cerevisiae on nonfermentable carbon sources. Eukaryot Cell 4(5):861-6 |
SGD |
| nucleus 2090 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| AAH1/YNL141W | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| IEA: Inferred from Electronic Annotation with HAMAP:MF_03145 Last Updated 2013-03-02 |
computational | Swiss Institute of Bioinformatics (SIB) curators and GOA curators (2006) Electronic Gene Ontology annotations created by transferring manual GO annotations between orthologous microbial proteins |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AAP1/YHR047C | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| AAR2/YBL074C | IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ABD1/YBR236C | IPI: Inferred from Physical Interaction Assigned on 2003-02-04 |
manually curated | Schroeder SC, et al. (2000) Dynamic association of capping enzymes with transcribing RNA polymerase II. Genes Dev 14(19):2435-40 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2013-06-06 |
manually curated | Ghosh Dastidar R, et al. (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR016899 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ABF1/YKL112W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2005-10-20 |
manually curated | Loch CM, et al. (2004) Functional and physical interactions between autonomously replicating sequence-binding factor 1 and the nuclear transport machinery. Traffic 5(12):925-35 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR006774 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ABF2/YMR072W | IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ACA1/YER045C | IC: Inferred By Curator from sequence-specific DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Assigned on 2011-08-04 |
manually curated | Garcia-Gimeno MA and Struhl K (2000) Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress. Mol Cell Biol 20(12):4340-9 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ACB1/YGR037C | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| ACE2/YLR131C | IDA: Inferred from Direct Assay Assigned on 2005-10-12 |
manually curated | Dohrmann PR, et al. (1992) Parallel pathways of gene regulation: homologous regulators SWI5 and ACE2 differentially control transcription of HO and chitinase. Genes Dev 6(1):93-104 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2005-10-12 |
manually curated | Archambault V, et al. (2004) Targeted proteomic study of the cyclin-Cdk module. Mol Cell 14(6):699-711 |
SGD | |
| IDA: Inferred from Direct Assay Assigned on 2012-12-12 |
high-throughput | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ACM1/YPL267W | IDA: Inferred from Direct Assay Assigned on 2008-08-22 |
manually curated | Enquist-Newman M, et al. (2008) Modulation of the Mitotic Regulatory Network by APC-Dependent Destruction of the Cdh1 Inhibitor Acm1. Mol Cell 30(4):437-46 |
SGD |
| ACS1/YAL054C | IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ACS2/YLR153C | IDA: Inferred from Direct Assay Assigned on 2006-11-07 |
manually curated | Takahashi H, et al. (2006) Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell 23(2):207-17 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2009-10-16 |
manually curated | Falcon AA, et al. (2010) Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae. Mol Cell Biochem 333(1-2):99-108 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ADA2/YDR448W | IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ADE1/YAR015W | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| ADE3/YGR204W | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ADE8/YDR408C | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| ADF1/YCL058W-A | IDA: Inferred from Direct Assay Assigned on 2010-03-10 |
manually curated | Li D, et al. (2010) A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand. Cell Res 20(4):408-20 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ADH5/YBR145W | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| ADI1/YMR009W | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ADO1/YJR105W | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| ADR1/YDR216W | IDA: Inferred from Direct Assay Assigned on 2002-07-26 |
manually curated | Sloan JS, et al. (1999) Post-translational regulation of Adr1 activity is mediated by its DNA binding domain. J Biol Chem 274(53):37575-82 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AFI1/YOR129C | IMP: Inferred from Mutant Phenotype Assigned on 2008-04-15 |
manually curated | Wysocka M, et al. (2003) YOR129c, a new element interacting with Cnm67p, a component of the spindle pole body of Saccharomyces cerevisiae. Acta Biochim Pol 50(3):883-90 |
SGD |
| IGI: Inferred from Genetic Interaction Assigned on 2008-04-15 |
manually curated | Tsai PC, et al. (2008) Afi1p Functions as an Arf3p Polarization-specific Docking Factor for Development of Polarity. J Biol Chem 283(24):16915-27 |
SGD | |
| AFT1/YGL071W | IDA: Inferred from Direct Assay Assigned on 2002-10-03 |
manually curated | Yamaguchi-Iwai Y, et al. (2002) Subcellular localization of Aft1 transcription factor responds to iron status in Saccharomyces cerevisiae. J Biol Chem 277(21):18914-8 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2007-03-29 |
manually curated | Kawahata M, et al. (2006) Yeast genes involved in response to lactic acid and acetic acid: acidic conditions caused by the organic acids in Saccharomyces cerevisiae cultures induce expression of intracellular metal metabolism genes regulated by Aft1p. FEMS Yeast Res 6(6):924-36 |
SGD | |
| IDA: Inferred from Direct Assay Assigned on 2012-12-12 |
high-throughput | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AFT2/YPL202C | IC: Inferred By Curator from RNA polymerase II core promoter proximal region sequence-specific DNA binding Assigned on 2012-01-05 |
manually curated | Courel M, et al. (2005) Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol 25(15):6760-71 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AHC1/YOR023C | IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AHC2/YCR082W | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AIF1/YNR074C | IDA: Inferred from Direct Assay Assigned on 2005-02-08 |
manually curated | Wissing S, et al. (2004) An AIF orthologue regulates apoptosis in yeast. J Cell Biol 166(7):969-74 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AIM20/YIL158W | IDA: Inferred from Direct Assay Assigned on 2012-12-12 |
high-throughput | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
SGD |
| AIM7/YDR063W | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AIP1/YMR092C | IDA: Inferred from Direct Assay Assigned on 2002-05-07 |
high-throughput | Kumar A, et al. (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19 |
SGD |
