Ontology: Molecular Function (GO:0005543)

Definition: Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term phospholipid binding (44 genes) or to its variants containing one or more qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	NOT: phospholipid binding	1
	phospholipid binding	14
High-throughput (download data)	phospholipid binding	1
Computational (download data)	phospholipid binding	32

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term phospholipid binding or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

phospholipid binding      44 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
AGE1/YDR524C	IDA: Inferred from Direct Assay Assigned on 2011-02-16	manually curated	Benjamin JJ, et al.  (2011) The Yeast Arf GTPase-activating Protein Age1 Is Regulated by Phospholipase D for Post-Golgi Vesicular Transport. J Biol Chem 286(7):5187-96	SGD
ASK10/YGR097W	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ASM4/YDL088C	IDA: Inferred from Direct Assay Assigned on 2011-05-25	manually curated	Patel SS and Rexach MF  (2008) Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibrium. Mol Cell Proteomics 7(1):121-31	SGD
ATG26/YLR189C	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BEM2/YER155C	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BEM3/YPL115C	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BOI1/YBL085W	IDA: Inferred from Direct Assay Assigned on 2002-12-09	manually curated	Hallett MA, et al.  (2002) Probing the importance and potential roles of the binding of the PH-domain protein Boi1 to acidic phospholipids. BMC Cell Biol 3():16	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BOI2/YER114C	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-12-09	manually curated	Hallett MA, et al.  (2002) Probing the importance and potential roles of the binding of the PH-domain protein Boi1 to acidic phospholipids. BMC Cell Biol 3():16	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BUD4/YJR092W	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CAF120/YNL278W	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CAM1/YPL048W	IDA: Inferred from Direct Assay Assigned on 2007-08-24	manually curated	Kambouris NG, et al.  (1993) Cloning and genetic characterization of a calcium- and phospholipid-binding protein from Saccharomyces cerevisiae that is homologous to translation elongation factor-1 gamma. Yeast 9(2):151-63	SGD
CDC24/YAL041W	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CLA4/YNL298W	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GLE1/YDL207W	IDA: Inferred from Direct Assay Assigned on 2011-05-25	manually curated	Patel SS and Rexach MF  (2008) Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibrium. Mol Cell Proteomics 7(1):121-31	SGD
INN1/YNL152W	ISS: Inferred from Sequence or structural Similarity with MGI:MGI:99665 Assigned on 2008-03-20	manually curated	Sanchez-Diaz A, et al.  (2008) Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast. Nat Cell Biol 10(4):395-406	SGD
	ISS: Inferred from Sequence or structural Similarity Assigned on 2004-01-05	high-throughput	Hazbun TR, et al.  (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65	SGD
IVY1/YDR229W	IDA: Inferred from Direct Assay Assigned on 2003-02-13	manually curated	Lazar T, et al.  (2002) A novel phospholipid-binding protein from the yeast Saccharomyces cerevisiae with dual binding specificities for the transport GTPase Ypt7p and the Sec1-related Vps33p. Eur J Cell Biol 81(12):635-46	SGD
NSP1/YJL041W	IDA: Inferred from Direct Assay Assigned on 2011-05-25	manually curated	Patel SS and Rexach MF  (2008) Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibrium. Mol Cell Proteomics 7(1):121-31	SGD
NUM1/YDR150W	IEA: Inferred from Electronic Annotation with EBI:IPR001849, EBI:IPR024774 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
NUP53/YMR153W	IDA: Inferred from Direct Assay Assigned on 2011-05-25	manually curated	Patel SS and Rexach MF  (2008) Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibrium. Mol Cell Proteomics 7(1):121-31	SGD
NUP60/YAR002W	IDA: Inferred from Direct Assay Assigned on 2011-05-25	manually curated	Patel SS and Rexach MF  (2008) Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibrium. Mol Cell Proteomics 7(1):121-31	SGD
NVJ2/YPR091C	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
OPY1/YBR129C	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
OSH2/YDL019C	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
OSH3/YHR073W	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RGC1/YPR115W	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SIP18/YMR175W	IDA: Inferred from Direct Assay Assigned on 2002-10-09	manually curated	Scheglmann D, et al.  (2002) Role of paired basic residues of protein C-termini in phospholipid binding. Protein Eng 15(6):521-8	SGD
SIP3/YNL257C	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SKG3/YLR187W	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SKM1/YOL113W	IEA: Inferred from Electronic Annotation with EBI:IPR001849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SLA2/YNL243W	IEA: Inferred from Electronic Annotation with EBI:IPR011417 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

NOT: phospholipid binding      1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
INN1/YNL152W	IDA: Inferred from Direct Assay Assigned on 2011-05-03	manually curated	Nishihama R, et al.  (2009) Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae. J Cell Biol 185(6):995-1012	SGD

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