GO term: protein binding 
Ontology: Molecular Function (GO:0005515)
Definition: Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
Synonyms: alpha-2 macroglobulin receptor-associated protein activity; protein amino acid binding; protein degradation tagging activity; protein tagging activity; protein folding chaperone
View Ontology:
(graph) | 
(text)
Definition: Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
Synonyms: alpha-2 macroglobulin receptor-associated protein activity; protein amino acid binding; protein degradation tagging activity; protein tagging activity; protein folding chaperone
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
protein binding (54 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | protein binding | 54 |
| High-throughput | none | none |
| Computational | none | none |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
protein binding or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| protein binding 54 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| AFG3/YER017C | IPI: Inferred from Physical Interaction with SGD:YTA12 Assigned on 2011-03-03 |
manually curated | Augustin S, et al. (2009) An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases. Mol Cell 35(5):574-85 |
SGD |
| AMN1/YBR158W | IPI: Inferred from Physical Interaction with SGD:TEM1 Assigned on 2003-05-28 |
manually curated | Wang Y, et al. (2003) Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling. Cell 112(5):697-709 |
SGD |
| APL5/YPL195W | IPI: Inferred from Physical Interaction with SGD:VPS41 Assigned on 2005-06-16 |
manually curated | Rehling P, et al. (1999) Formation of AP-3 transport intermediates requires Vps41 function. Nat Cell Biol 1(6):346-53 |
SGD |
| BNI4/YNL233W | IPI: Inferred from Physical Interaction with SGD:GLC7 Assigned on 2011-03-02 |
manually curated | Kozubowski L, et al. (2003) A Bni4-Glc7 phosphatase complex that recruits chitin synthase to the site of bud emergence. Mol Biol Cell 14(1):26-39 |
SGD |
| IPI: Inferred from Physical Interaction with SGD:SKT5, SGD:CDC10 Assigned on 2011-03-01 |
manually curated | DeMarini DJ, et al. (1997) A septin-based hierarchy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall. J Cell Biol 139(1):75-93 |
SGD | |
| BSD2/YBR290W | IPI: Inferred from Physical Interaction with SGD:RSP5 Assigned on 2011-02-10 |
manually curated | Hettema EH, et al. (2004) Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins. EMBO J 23(6):1279-88 |
SGD |
| BUB1/YGR188C | IPI: Inferred from Physical Interaction with SGD:SKP1 Assigned on 2003-07-25 |
manually curated | Kitagawa K, et al. (2003) Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint. Mol Cell 11(5):1201-13 |
SGD |
| CDC6/YJL194W | IPI: Inferred from Physical Interaction with SGD:CDC4 Assigned on 2003-07-02 |
manually curated | Drury LS, et al. (1997) The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J 16(19):5966-76 |
SGD |
| IPI: Inferred from Physical Interaction with SGD:ORC1 Assigned on 2007-08-10 |
manually curated | Wang B, et al. (1999) The essential role of Saccharomyces cerevisiae CDC6 nucleotide-binding site in cell growth, DNA synthesis, and Orc1 association. J Biol Chem 274(12):8291-8 |
SGD | |
| CMD1/YBR109C | IPI: Inferred from Physical Interaction with SGD:SPC110 Assigned on 2007-07-16 |
manually curated | Stirling DA, et al. (1994) Interaction with calmodulin is required for the function of Spc110p, an essential component of the yeast spindle pole body. EMBO J 13(18):4329-42 |
SGD |
| IPI: Inferred from Physical Interaction with SGD:ARC35 Assigned on 2007-07-17 |
manually curated | Schaerer-Brodbeck C and Riezman H (2000) Functional interactions between the p35 subunit of the Arp2/3 complex and calmodulin in yeast. Mol Biol Cell 11(4):1113-27 |
SGD | |
| IPI: Inferred from Physical Interaction with SGD:MYO2 Assigned on 2007-07-16 |
manually curated | Brockerhoff SE, et al. (1994) The unconventional myosin, Myo2p, is a calmodulin target at sites of cell growth in Saccharomyces cerevisiae. J Cell Biol 124(3):315-23 |
SGD | |
| IPI: Inferred from Physical Interaction with SGD:MYO5 Assigned on 2007-07-17 |
manually curated | Geli MI, et al. (1998) Distinct functions of calmodulin are required for the uptake step of receptor-mediated endocytosis in yeast: the type I myosin Myo5p is one of the calmodulin targets. EMBO J 17(3):635-47 |
SGD | |
| IPI: Inferred from Physical Interaction with SGD:SPC110 Assigned on 2007-07-16 |
manually curated | Geiser JR, et al. (1993) The essential mitotic target of calmodulin is the 110-kilodalton component of the spindle pole body in Saccharomyces cerevisiae. Mol Cell Biol 13(12):7913-24 |
SGD | |
| DHH1/YDL160C | IPI: Inferred from Physical Interaction with SGD:PAT1, SGD:LSM1, SGD:DCP1 Assigned on 2002-11-08 |
manually curated | Coller JM, et al. (2001) The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes. RNA 7(12):1717-27 |
SGD |
| DPB11/YJL090C | IPI: Inferred from Physical Interaction with SGD:POL2 Assigned on 2004-09-28 |
manually curated | Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 |
SGD |
| ENT3/YJR125C | IPI: Inferred from Physical Interaction with SGD:GGA2 Assigned on 2004-01-07 |
manually curated | Duncan MC, et al. (2003) Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif. Nat Cell Biol 5(1):77-81 |
SGD |
| GAL3/YDR009W | IPI: Inferred from Physical Interaction with SGD:GAL80 Assigned on 2011-06-22 |
manually curated | Suzuki-Fujimoto T, et al. (1996) Analysis of the galactose signal transduction pathway in Saccharomyces cerevisiae: interaction between Gal3p and Gal80p. Mol Cell Biol 16(5):2504-8 |
SGD |
| GYL1/YMR192W | IPI: Inferred from Physical Interaction with SGD:RVS161, SGD:RVS167 Assigned on 2011-02-28 |
manually curated | Bon E, et al. (2000) A network of proteins around Rvs167p and Rvs161p, two proteins related to the yeast actin cytoskeleton. Yeast 16(13):1229-41 |
SGD |
| IPI: Inferred from Physical Interaction with SGD:RVS167 Assigned on 2011-02-28 |
manually curated | Friesen H, et al. (2003) Regulation of the yeast amphiphysin homologue Rvs167p by phosphorylation. Mol Biol Cell 14(7):3027-40 |
SGD | |
| IPI: Inferred from Physical Interaction with SGD:RVS167, SGD:GYP5 Assigned on 2011-02-28 |
manually curated | Friesen H, et al. (2005) Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking. Genetics 170(2):555-68 |
SGD | |
| HOP2/YGL033W | IPI: Inferred from Physical Interaction with SGD:MND1 Assigned on 2004-10-08 |
manually curated | Chen YK, et al. (2004) Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation. Proc Natl Acad Sci U S A 101(29):10572-7 |
SGD |
| IOC2/YLR095C | IPI: Inferred from Physical Interaction with SGD:ISW1 Assigned on 2011-02-10 |
manually curated | Vary JC Jr, et al. (2003) Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol 23(1):80-91 |
SGD |
| IWR1/YDL115C | IPI: Inferred from Physical Interaction with SGD:RPO21, SGD:RPB2 Assigned on 2011-06-13 |
manually curated | Czeko E, et al. (2011) Iwr1 Directs RNA Polymerase II Nuclear Import. Mol Cell 42(2):261-6 |
SGD |
| IZH2/YOL002C | IPI: Inferred from Physical Interaction with GenBank/EMBL/DDBJ:CAA46622 Assigned on 2007-01-04 |
manually curated | Narasimhan ML, et al. (2005) Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor. Mol Cell 17(2):171-80 |
SGD |
| KAR1/YNL188W | IPI: Inferred from Physical Interaction with SGD:SPC72 Assigned on 2011-03-01 |
manually curated | Pereira G, et al. (1999) Interaction of the yeast gamma-tubulin complex-binding protein Spc72p with Kar1p is essential for microtubule function during karyogamy. EMBO J 18(15):4180-95 |
SGD |
| IPI: Inferred from Physical Interaction with SGD:CDC31 Assigned on 2011-03-01 |
manually curated | Biggins S and Rose MD (1994) Direct interaction between yeast spindle pole body components: Kar1p is required for Cdc31p localization to the spindle pole body. J Cell Biol 125(4):843-52 |
SGD | |
| LIN1/YHR156C | IPI: Inferred from Physical Interaction with SGD:WSS1, SGD:RFC1, SGD:NFI1, SGD:PRP8, SGD:DAS1, SGD:SLX5, SGD:IRR1 Assigned on 2003-05-28 |
manually curated | Bialkowska A and Kurlandzka A (2002) Proteins interacting with Lin 1p, a putative link between chromosome segregation, mRNA splicing and DNA replication in Saccharomyces cerevisiae. Yeast 19(15):1323-33 |
SGD |
| LST8/YNL006W | IPI: Inferred from Physical Interaction with SGD:TOR2, SGD:TOR1 Assigned on 2003-06-04 |
manually curated | Wedaman KP, et al. (2003) Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell 14(3):1204-20 |
SGD |
| MCM10/YIL150C | IPI: Inferred from Physical Interaction with SGD:POL1 Assigned on 2006-10-20 |
manually curated | Ricke RM and Bielinsky AK (2006) A conserved Hsp10-like domain in Mcm10 is required to stabilize the catalytic subunit of DNA polymerase-alpha in budding yeast. J Biol Chem 281(27):18414-25 |
SGD |
| MEX67/YPL169C | IPI: Inferred from Physical Interaction with SGD:SAC3 Assigned on 2003-06-05 |
manually curated | Fischer T, et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J 21(21):5843-52 |
SGD |
| MND1/YGL183C | IPI: Inferred from Physical Interaction with SGD:HOP2 Assigned on 2004-10-08 |
manually curated | Chen YK, et al. (2004) Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation. Proc Natl Acad Sci U S A 101(29):10572-7 |
SGD |
| MSN5/YDR335W | IPI: Inferred from Physical Interaction with SGD:SWI6 Assigned on 2003-06-18 |
manually curated | Queralt E and Igual JC (2003) Cell cycle activation of the Swi6p transcription factor is linked to nucleocytoplasmic shuttling. Mol Cell Biol 23(9):3126-40 |
SGD |
| MTR2/YKL186C | IPI: Inferred from Physical Interaction with SGD:MEX67 Assigned on 2011-02-10 |
manually curated | Strasser K, et al. (2000) Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export. J Cell Biol 150(4):695-706 |
SGD |
| NVJ1/YHR195W | IPI: Inferred from Physical Interaction with SGD:VAC8 Assigned on 2011-03-15 |
manually curated | Pan X, et al. (2000) Nucleus-vacuole junctions in Saccharomyces cerevisiae are formed through the direct interaction of Vac8p with Nvj1p. Mol Biol Cell 11(7):2445-57 |
SGD |
| PEX10/YDR265W | IPI: Inferred from Physical Interaction with SGD:PEX2, SGD:PEX12 Assigned on 2007-06-15 |
manually curated | Agne B, et al. (2003) Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. Mol Cell 11(3):635-46 |
SGD |
| PEX12/YMR026C | IPI: Inferred from Physical Interaction with SGD:PEX2, SGD:PEX10 Assigned on 2007-06-15 |
manually curated | Agne B, et al. (2003) Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. Mol Cell 11(3):635-46 |
SGD |
| PEX17/YNL214W | IPI: Inferred from Physical Interaction with SGD:PEX14 Assigned on 2011-03-01 |
manually curated | Huhse B, et al. (1998) Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery. J Cell Biol 140(1):49-60 |
SGD |
| IPI: Inferred from Physical Interaction with SGD:PEX14 Assigned on 2011-03-01 |
manually curated | Agne B, et al. (2003) Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. Mol Cell 11(3):635-46 |
SGD | |
| PEX18/YHR160C | IPI: Inferred from Physical Interaction with SGD:PEX7 Assigned on 2011-02-11 |
manually curated | Purdue PE, et al. (1998) Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway. J Cell Biol 143(7):1859-69 |
SGD |
