Ontology: Molecular Function (GO:0005198)

Definition: The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term structural molecule activity (45 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	structural molecule activity	36
High-throughput	none	none
Computational (download data)	structural molecule activity	11

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term structural molecule activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

structural molecule activity      45 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ADY4/YLR227C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2003-07-08	manually curated	Nickas ME, et al.  (2003) Ady4p and Spo74p are components of the meiotic spindle pole body that promote growth of the prospore membrane in Saccharomyces cerevisiae. Eukaryot Cell 2(3):431-45	SGD
ARC15/YIL062C	IMP: Inferred from Mutant Phenotype Assigned on 2003-02-13	manually curated	Winter DC, et al.  (1999) Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A 96(13):7288-93	SGD
ARC19/YKL013C	IMP: Inferred from Mutant Phenotype Assigned on 2003-02-13	manually curated	Winter DC, et al.  (1999) Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A 96(13):7288-93	SGD
ARC35/YNR035C	IMP: Inferred from Mutant Phenotype Assigned on 2003-02-18	manually curated	Winter DC, et al.  (1999) Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A 96(13):7288-93	SGD
ATP20/YPR020W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2001-01-18	manually curated	Arnold I, et al.  (1998) Yeast mitochondrial F1F0-ATP synthase exists as a dimer: identification of three dimer-specific subunits. EMBO J 17(24):7170-8	SGD
CDC10/YCR002C	IDA: Inferred from Direct Assay Assigned on 2011-10-07	manually curated	Bertin A, et al.  (2008) Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly. Proc Natl Acad Sci U S A 105(24):8274-9	SGD
CDC11/YJR076C	IDA: Inferred from Direct Assay Assigned on 2011-10-07	manually curated	Bertin A, et al.  (2008) Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly. Proc Natl Acad Sci U S A 105(24):8274-9	SGD
CDC12/YHR107C	IDA: Inferred from Direct Assay Assigned on 2011-10-07	manually curated	Bertin A, et al.  (2008) Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly. Proc Natl Acad Sci U S A 105(24):8274-9	SGD
CDC3/YLR314C	IDA: Inferred from Direct Assay Assigned on 2011-10-07	manually curated	Bertin A, et al.  (2008) Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly. Proc Natl Acad Sci U S A 105(24):8274-9	SGD
CHC1/YGL206C	TAS: Traceable Author Statement Assigned on 2002-07-15	manually curated	Pishvaee B, et al.  (1997) A novel structural model for regulation of clathrin function. EMBO J 16(9):2227-39	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001473, EBI:IPR015348, EBI:IPR016025 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CHL4/YDR254W	IMP: Inferred from Mutant Phenotype Assigned on 2010-07-08	manually curated	Mythreye K and Bloom KS  (2003) Differential kinetochore protein requirements for establishment versus propagation of centromere activity in Saccharomyces cerevisiae. J Cell Biol 160(6):833-43	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2010-07-08	manually curated	Pot I, et al.  (2003) Chl4p and iml3p are two new members of the budding yeast outer kinetochore. Mol Biol Cell 14(2):460-76	SGD
CLC1/YGR167W	TAS: Traceable Author Statement Assigned on 2002-07-15	manually curated	Pishvaee B, et al.  (1997) A novel structural model for regulation of clathrin function. EMBO J 16(9):2227-39	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000996 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
COP1/YDL145C	IEA: Inferred from Electronic Annotation with EBI:IPR006692, EBI:IPR010714 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CSE2/YNR010W	IMP: Inferred from Mutant Phenotype Assigned on 2011-07-18	manually curated	Takahashi H, et al.  (2009) Saccharomyces cerevisiae Med9 comprises two functionally distinct domains that play different roles in transcriptional regulation. Genes Cells 14(1):53-67	SGD
GAC1/YOR178C	TAS: Traceable Author Statement Assigned on 2005-10-07	manually curated	Williams-Hart T, et al.  (2002) Protein phosphatase type 1 regulates ion homeostasis in Saccharomyces cerevisiae. Genetics 160(4):1423-37	SGD
ISA1/YLL027W	IEA: Inferred from Electronic Annotation with EBI:IPR016092 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MED8/YBR193C	IMP: Inferred from Mutant Phenotype Assigned on 2011-08-15	manually curated	Lariviere L, et al.  (2008) Structure-system correlation identifies a gene regulatory Mediator submodule. Genes Dev 22(7):872-877	SGD
MPC54/YOR177C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2003-07-08	manually curated	Nickas ME, et al.  (2003) Ady4p and Spo74p are components of the meiotic spindle pole body that promote growth of the prospore membrane in Saccharomyces cerevisiae. Eukaryot Cell 2(3):431-45	SGD
PDS5/YMR076C	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-10-01	manually curated	Panizza S, et al.  (2000) Pds5 cooperates with cohesin in maintaining sister chromatid cohesion. Curr Biol 10(24):1557-64	SGD
PDX1/YGR193C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2010-03-12	manually curated	Lawson JE, et al.  (1991) Disruption and mutagenesis of the Saccharomyces cerevisiae PDX1 gene encoding the protein X component of the pyruvate dehydrogenase complex. Biochemistry 30(11):2834-9	SGD
PUN1/YLR414C	IEA: Inferred from Electronic Annotation with EBI:IPR017974 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RED1/YLR263W	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction Assigned on 2005-10-14	manually curated	de los Santos T, et al.  (2001) A role for MMS4 in the processing of recombination intermediates during meiosis in Saccharomyces cerevisiae. Genetics 159(4):1511-25	SGD
RPN10/YHR200W	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-26	manually curated	Glickman MH, et al.  (1998) A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell 94(5):615-23	SGD
RPN6/YDL097C	IMP: Inferred from Mutant Phenotype Assigned on 2003-04-23	manually curated	Santamaria PG, et al.  (2003) Rpn6p, a proteasome subunit from Saccharomyces cerevisiae, is essential for the assembly and activity of the 26 S proteasome. J Biol Chem 278(9):6687-95	SGD
RPN7/YPR108W	IMP: Inferred from Mutant Phenotype Assigned on 2004-07-06	manually curated	Isono E, et al.  (2004) Rpn7 Is required for the structural integrity of the 26 S proteasome of Saccharomyces cerevisiae. J Biol Chem 279(26):27168-76	SGD
RPN9/YDR427W	IMP: Inferred from Mutant Phenotype Assigned on 2004-07-06	manually curated	Takeuchi J, et al.  (1999) Rpn9 is required for efficient assembly of the yeast 26S proteasome. Mol Cell Biol 19(10):6575-84	SGD
SCS2/YER120W	IEA: Inferred from Electronic Annotation with EBI:IPR000535 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SCS22/YBL091C-A	IEA: Inferred from Electronic Annotation with EBI:IPR000535 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SEC13/YLR208W	IDA: Inferred from Direct Assay Assigned on 2012-06-11	manually curated	Antonny B, et al.  (2003) Self-assembly of minimal COPII cages. EMBO Rep 4(4):419-24	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-12-15	manually curated	Fath S, et al.  (2007) Structure and organization of coat proteins in the COPII cage. Cell 129(7):1325-36	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2012-06-11	manually curated	Copic A, et al.  (2012) ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p. Science 335(6074):1359-62	SGD
SEC21/YNL287W	IEA: Inferred from Electronic Annotation with EBI:IPR014863, EBI:IPR013040 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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