Ontology: Biological Process (GO:0051382)

Definition: The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

Synonyms: centromere and kinetochore complex maturation; centromere/kinetochore complex maturation; kinetochore biogenesis; kinetochore biosynthesis; kinetochore formation; chromosome-kinetochore attachment

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term kinetochore assembly (6 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	kinetochore assembly	6
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term kinetochore assembly or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

kinetochore assembly      6 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ARP4/YJL081C	IMP: Inferred from Mutant Phenotype Assigned on 2008-09-23	manually curated	Ogiwara H, et al.  (2007) Actin-related protein Arp4 functions in kinetochore assembly. Nucleic Acids Res 35(9):3109-17	SGD
CHL4/YDR254W	IMP: Inferred from Mutant Phenotype Assigned on 2010-07-07	manually curated	Mythreye K and Bloom KS  (2003) Differential kinetochore protein requirements for establishment versus propagation of centromere activity in Saccharomyces cerevisiae. J Cell Biol 160(6):833-43	SGD
CTF13/YMR094W	IDA: Inferred from Direct Assay Assigned on 2005-07-20	manually curated	Stemmann O, et al.  (2002) Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore. Proc Natl Acad Sci U S A 99(13):8585-90	SGD
SCM3/YDL139C	IMP: Inferred from Mutant Phenotype Assigned on 2013-04-26	manually curated	Camahort R, et al.  (2007) Scm3 is essential to recruit the histone h3 variant cse4 to centromeres and to maintain a functional kinetochore. Mol Cell 26(6):853-65	SGD
SGT1/YOR057W	IDA: Inferred from Direct Assay Assigned on 2005-07-20	manually curated	Kitagawa K, et al.  (1999) SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol Cell 4(1):21-33	SGD
SKP1/YDR328C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2005-07-20	manually curated	Stemmann O, et al.  (2002) Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore. Proc Natl Acad Sci U S A 99(13):8585-90	SGD

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