Ontology: Biological Process (GO:0051276)

Definition: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information.

Synonyms: maintenance of genome integrity; nuclear genome maintenance; chromosome organization and biogenesis; chromosome organisation

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term chromosome organization (16 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	chromosome organization	11
High-throughput	none	none
Computational (download data)	chromosome organization	5

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term chromosome organization or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

chromosome organization      16 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ECO1/YFR027W	IMP: Inferred from Mutant Phenotype Assigned on 2009-12-07	manually curated	Gard S, et al.  (2009) Cohesinopathy mutations disrupt the subnuclear organization of chromatin. J Cell Biol 187(4):455-62	SGD
INN1/YNL152W	IMP: Inferred from Mutant Phenotype Assigned on 2008-06-20	manually curated	Ben-Aroya S, et al.  (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30(2):248-58	SGD
KAE1/YKR038C	IMP: Inferred from Mutant Phenotype Assigned on 2008-06-20	manually curated	Ben-Aroya S, et al.  (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30(2):248-58	SGD
KEG1/YFR042W	IMP: Inferred from Mutant Phenotype Assigned on 2008-06-20	manually curated	Ben-Aroya S, et al.  (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30(2):248-58	SGD
LOH1/YJL038C	IMP: Inferred from Mutant Phenotype Assigned on 2008-07-25	manually curated	Andersen MP, et al.  (2008) A Genetic Screen for Increased Loss of Heterozygosity in Saccharomyces cerevisiae. Genetics 179(3):1179-95	SGD
NUP60/YAR002W	IMP: Inferred from Mutant Phenotype Assigned on 2012-06-11	manually curated	Ruben GJ, et al.  (2011) Nucleoporin Mediated Nuclear Positioning and Silencing of HMR. PLoS One 6(7):e21923	SGD
PDS1/YDR113C	IEA: Inferred from Electronic Annotation with EBI:IPR006940 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PIF1/YML061C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Schulz VP and Zakian VA  (1994) The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation. Cell 76(1):145-55	SGD
SGS1/YMR190C	IMP: Inferred from Mutant Phenotype Assigned on 2002-08-06	manually curated	Myung K, et al.  (2001) SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination. Nat Genet 27(1):113-6	SGD
SMC1/YFL008W	IEA: Inferred from Electronic Annotation with EBI:IPR010935 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SMC2/YFR031C	IEA: Inferred from Electronic Annotation with EBI:IPR010935 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SMC3/YJL074C	IEA: Inferred from Electronic Annotation with EBI:IPR010935 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SMC4/YLR086W	IEA: Inferred from Electronic Annotation with EBI:IPR010935 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SWC4/YGR002C	IMP: Inferred from Mutant Phenotype Assigned on 2008-06-20	manually curated	Ben-Aroya S, et al.  (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30(2):248-58	SGD
TRS23/YDR246W	IMP: Inferred from Mutant Phenotype Assigned on 2008-06-20	manually curated	Ben-Aroya S, et al.  (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30(2):248-58	SGD
YTM1/YOR272W	IGI: Inferred from Genetic Interaction Assigned on 2002-12-05	manually curated	Ouspenski II, et al.  (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8	SGD

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