Ontology: Molecular Function (GO:0051087)

Definition: Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.

Synonyms: co-chaperone activity; co-chaperonin activity; chaperone protein binding

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term chaperone binding (21 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	chaperone binding	19
High-throughput	none	none
Computational (download data)	chaperone binding	5

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term chaperone binding or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

chaperone binding      21 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
AHA1/YDR214W	IDA: Inferred from Direct Assay Assigned on 2006-06-30	manually curated	Panaretou B, et al.  (2002) Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Mol Cell 10(6):1307-18	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR015310 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BTN2/YGR142W	IPI: Inferred from Physical Interaction with SGD:SIS1 Assigned on 2012-12-03	manually curated	Malinovska L, et al.  (2012) Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates. Mol Biol Cell 23(16):3041-56	SGD
CAJ1/YER048C	ISS: Inferred from Sequence or structural Similarity with EBI:P08622 Assigned on 2009-03-04	manually curated	Mukai H, et al.  (1994) Isolation and characterization of CAJ1, a novel yeast homolog of dnaJ. Gene 145(1):125-7	SGD
CUR1/YPR158W	IPI: Inferred from Physical Interaction with SGD:SIS1 Assigned on 2012-07-10	manually curated	Malinovska L, et al.  (2012) Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates. Mol Biol Cell 23(16):3041-56	SGD
DJP1/YIR004W	ISS: Inferred from Sequence or structural Similarity with CGSC:DnaJ, SGD:CAJ1, SGD:SCJ1, SGD:MDJ1, SGD:SIS1, SGD:YDJ1 Assigned on 2004-07-20	manually curated	Hettema EH, et al.  (1998) The cytosolic DnaJ-like protein djp1p is involved specifically in peroxisomal protein import. J Cell Biol 142(2):421-34	SGD
EPS1/YIL005W	IDA: Inferred from Direct Assay Assigned on 2007-11-08	manually curated	Kimura T, et al.  (2005) Interactions among Yeast Protein-Disulfide Isomerase Proteins and Endoplasmic Reticulum Chaperone Proteins Influence Their Activities. J Biol Chem 280(36):31438-41	SGD
HCH1/YNL281W	IDA: Inferred from Direct Assay Assigned on 2006-06-30	manually curated	Panaretou B, et al.  (2002) Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Mol Cell 10(6):1307-18	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR015310 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HSP10/YOR020C	IPI: Inferred from Physical Interaction with SGD:HSP60 Assigned on 2008-08-11	manually curated	Dubaquie Y, et al.  (1997) Significance of chaperonin 10-mediated inhibition of ATP hydrolysis by chaperonin 60. Proc Natl Acad Sci U S A 94(17):9011-6	SGD
HSP104/YLL026W	IDA: Inferred from Direct Assay Assigned on 2004-07-21	manually curated	Glover JR and Lindquist S  (1998) Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins. Cell 94(1):73-82	SGD
HSP60/YLR259C	IPI: Inferred from Physical Interaction with SGD:HSP10 Assigned on 2008-08-11	manually curated	Dubaquie Y, et al.  (1997) Significance of chaperonin 10-mediated inhibition of ATP hydrolysis by chaperonin 60. Proc Natl Acad Sci U S A 94(17):9011-6	SGD
JAC1/YGL018C	ISS: Inferred from Sequence or structural Similarity Assigned on 2004-07-22	manually curated	Strain J, et al.  (1998) Suppressors of superoxide dismutase (SOD1) deficiency in Saccharomyces cerevisiae. Identification of proteins predicted to mediate iron-sulfur cluster assembly. J Biol Chem 273(47):31138-44	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2004-07-22	manually curated	Kim R, et al.  (2001) J-domain protein, Jac1p, of yeast mitochondria required for iron homeostasis and activity of Fe-S cluster proteins. J Biol Chem 276(20):17524-32	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR004640 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
JEM1/YJL073W	ISS: Inferred from Sequence or structural Similarity Assigned on 2004-07-22	manually curated	Nishikawa S and Endo T  (1997) The yeast JEM1p is a DnaJ-like protein of the endoplasmic reticulum membrane required for nuclear fusion. J Biol Chem 272(20):12889-92	SGD
MGE1/YOR232W	IEA: Inferred from Electronic Annotation with EBI:IPR000740 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SBA1/YKL117W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2004-07-23	manually curated	Fang Y, et al.  (1998) SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins. Mol Cell Biol 18(7):3727-34	SGD
SCJ1/YMR214W	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2004-07-23	manually curated	Silberstein S, et al.  (1998) A role for the DnaJ homologue Scj1p in protein folding in the yeast endoplasmic reticulum. J Cell Biol 143(4):921-33	SGD
SGT1/YOR057W	ISS: Inferred from Sequence or structural Similarity Assigned on 2004-07-23	manually curated	Dubacq C, et al.  (2002) Sgt1p contributes to cyclic AMP pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast. Eukaryot Cell 1(4):568-82	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-03-04	manually curated	Catlett MG and Kaplan KB  (2006) Sgt1p is a unique co-chaperone that acts as a client adaptor to link Hsp90 to Skp1p. J Biol Chem 281(44):33739-48	SGD
SNL1/YIL016W	IEA: Inferred from Electronic Annotation with EBI:IPR003103 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
TAH1/YCR060W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:HSP82 Assigned on 2005-03-16	manually curated	Zhao R, et al.  (2005) Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell 120(5):715-27	SGD
	IDA: Inferred from Direct Assay Assigned on 2008-04-21	manually curated	Millson SH, et al.  (2008) Chaperone ligand-discrimination by the TPR-domain protein Tah1. Biochem J 413(2):261-8	SGD
TIM44/YIL022W	IMP: Inferred from Mutant Phenotype Assigned on 2009-08-05	manually curated	Milisav I, et al.  (2001) Modular structure of the TIM23 preprotein translocase of mitochondria. J Biol Chem 276(28):25856-61	SGD
	IPI: Inferred from Physical Interaction with SGD:SSC1 Assigned on 2009-08-05	manually curated	Kronidou NG, et al.  (1994) Dynamic interaction between Isp45 and mitochondrial hsp70 in the protein import system of the yeast mitochondrial inner membrane. Proc Natl Acad Sci U S A 91(26):12818-22	SGD
XDJ1/YLR090W	ISS: Inferred from Sequence or structural Similarity with EBI:P08622 Assigned on 2009-03-04	manually curated	Schwarz E, et al.  (1994) XDJ1, a gene encoding a novel non-essential DnaJ homologue from Saccharomyces cerevisiae. Gene 145(1):121-4	SGD
ZIM17/YNL310C	IDA: Inferred from Direct Assay Assigned on 2011-02-11	manually curated	Sichting M, et al.  (2005) Maintenance of structure and function of mitochondrial Hsp70 chaperones requires the chaperone Hep1. EMBO J 24(5):1046-56	SGD

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