Ontology: Molecular Function (GO:0051082)

Definition: Interacting selectively and non-covalently with an unfolded protein.

Synonyms: chaperone activity; glycoprotein-specific chaperone activity; tubulin-specific chaperone activity; ribosomal chaperone activity; fimbrium-specific chaperone activity; histone-specific chaperone activity; binding unfolded ER proteins

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term unfolded protein binding (78 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	unfolded protein binding	65
High-throughput (download data)	unfolded protein binding	1
Computational (download data)	unfolded protein binding	28

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term unfolded protein binding or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

unfolded protein binding      78 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
APJ1/YNL077W	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2003-01-20	manually curated	Kryndushkin DS, et al.  (2002) Increased expression of Hsp40 chaperones, transcriptional factors, and ribosomal protein Rpp0 can cure yeast prions. J Biol Chem 277(26):23702-8	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001305, EBI:IPR002939, EBI:IPR008971 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ATP10/YLR393W	IPI: Inferred from Physical Interaction with SGD:ATP6 Assigned on 2008-02-04	manually curated	Tzagoloff A, et al.  (2004) Atp10p assists assembly of Atp6p into the F0 unit of the yeast mitochondrial ATPase. J Biol Chem 279(19):19775-80	SGD
ATP11/YNL315C	IPI: Inferred from Physical Interaction Assigned on 2001-01-18	manually curated	Wang ZG and Ackerman SH  (2000) The assembly factor Atp11p binds to the beta-subunit of the mitochondrial F(1)-ATPase. J Biol Chem 275(8):5767-72	SGD
	IDA: Inferred from Direct Assay Assigned on 2004-01-07	manually curated	Hinton A, et al.  (2003) A purified subfragment of yeast Atp11p retains full molecular chaperone activity. J Biol Chem 278(36):34110-3	SGD
BTT1/YDR252W	IMP: Inferred from Mutant Phenotype Assigned on 2001-03-27	manually curated	Reimann B, et al.  (1999) Initial characterization of the nascent polypeptide-associated complex in yeast. Yeast 15(5):397-407	SGD
BUD27/YFL023W	IEA: Inferred from Electronic Annotation with EBI:IPR004127 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT2/YIL142W	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002194, EBI:IPR012716 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT3/YJL014W	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002194, EBI:IPR012719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT4/YDL143W	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002194, EBI:IPR012717 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT5/YJR064W	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002194, EBI:IPR012718 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT6/YDR188W	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002194, EBI:IPR012722 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT7/YJL111W	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002194, EBI:IPR012720 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT8/YJL008C	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002194, EBI:IPR012721 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CDC37/YDR168W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Kimura Y, et al.  (1997) Cdc37 is a molecular chaperone with specific functions in signal transduction. Genes Dev 11(14):1775-85	SGD
CHS7/YHR142W	IMP: Inferred from Mutant Phenotype Assigned on 2008-07-31	manually curated	Kota J and Ljungdahl PO  (2005) Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER. J Cell Biol 168(1):79-88	SGD
CNE1/YAL058W	IMP: Inferred from Mutant Phenotype Assigned on 2005-05-03	manually curated	Xu X, et al.  (2004) Expression and characterization of Saccharomyces cerevisiae Cne1p, a calnexin homologue. J Biochem 135(5):615-8	SGD
	ISS: Inferred from Sequence or structural Similarity Assigned on 2005-05-03	manually curated	Parlati F, et al.  (1995) Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticulum (ER) membrane protein with sequence similarity to calnexin and calreticulin and functions as a constituent of the ER quality control apparatus. J Biol Chem 270(1):244-53	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001580 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
COX20/YDR231C	IDA: Inferred from Direct Assay Assigned on 2002-06-10	manually curated	Hell K, et al.  (2000) Identification of Cox20p, a novel protein involved in the maturation and assembly of cytochrome oxidase subunit 2. J Biol Chem 275(7):4571-8	SGD
CPR6/YLR216C	IDA: Inferred from Direct Assay Assigned on 2002-11-26	manually curated	Mayr C, et al.  (2000) Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties. J Biol Chem 275(44):34140-6	SGD
CPR7/YJR032W	IDA: Inferred from Direct Assay Assigned on 2002-11-26	manually curated	Mayr C, et al.  (2000) Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties. J Biol Chem 275(44):34140-6	SGD
ECM10/YEL030W	IEA: Inferred from Electronic Annotation with EBI:IPR012725 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
EGD1/YPL037C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	George R, et al.  (1998) The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo. Proc Natl Acad Sci U S A 95(5):2296-301	SGD
EGD2/YHR193C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	George R, et al.  (1998) The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo. Proc Natl Acad Sci U S A 95(5):2296-301	SGD
EPS1/YIL005W	IDA: Inferred from Direct Assay Assigned on 2007-11-08	manually curated	Kimura T, et al.  (2005) Interactions among Yeast Protein-Disulfide Isomerase Proteins and Endoplasmic Reticulum Chaperone Proteins Influence Their Activities. J Biol Chem 280(36):31438-41	SGD
GIM3/YNL153C	IEA: Inferred from Electronic Annotation with EBI:IPR002777 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GIM4/YEL003W	IEA: Inferred from Electronic Annotation with EBI:IPR002777 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GIM5/YML094W	IEA: Inferred from Electronic Annotation with EBI:IPR004127, EBI:IPR011599 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GSF2/YML048W	IMP: Inferred from Mutant Phenotype Assigned on 2008-07-31	manually curated	Kota J and Ljungdahl PO  (2005) Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER. J Cell Biol 168(1):79-88	SGD
HSC82/YMR186W	IDA: Inferred from Direct Assay Assigned on 2006-06-13	manually curated	Scheibel T, et al.  (1998) Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence. Proc Natl Acad Sci U S A 95(4):1495-9	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR019805, EBI:IPR001404 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HSP10/YOR020C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Rospert S, et al.  (1993) Identification and functional analysis of chaperonin 10, the groES homolog from yeast mitochondria. Proc Natl Acad Sci U S A 90(23):10967-71	SGD
HSP104/YLL026W	IDA: Inferred from Direct Assay Assigned on 2009-02-13	manually curated	Bosl B, et al.  (2005) Substrate binding to the molecular chaperone Hsp104 and its regulation by nucleotides. J Biol Chem 280(46):38170-6	SGD
HSP26/YBR072W	IDA: Inferred from Direct Assay Assigned on 2003-03-27	manually curated	Haslbeck M, et al.  (1999) Hsp26: a temperature-regulated chaperone. EMBO J 18(23):6744-51	SGD

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