Ontology: Molecular Function (GO:0000049)

Definition: Interacting selectively and non-covalently with transfer RNA.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term tRNA binding (16 genes) or to its variants containing one or more qualifiers (4 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	contributes_to: tRNA binding	4
	tRNA binding	9
High-throughput	none	none
Computational (download data)	tRNA binding	10

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term tRNA binding or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

contributes_to: tRNA binding      4 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ELP4/YPL101W	IDA: Inferred from Direct Assay Assigned on 2012-03-07	manually curated	Glatt S, et al.  (2012) The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase.LID - 10.1038/nsmb.2234 [doi] Nat Struct Mol Biol ()	SGD
ELP6/YMR312W	IDA: Inferred from Direct Assay Assigned on 2012-03-07	manually curated	Glatt S, et al.  (2012) The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase.LID - 10.1038/nsmb.2234 [doi] Nat Struct Mol Biol ()	SGD
GCD11/YER025W	IMP: Inferred from Mutant Phenotype Assigned on 2009-12-07	manually curated	Erickson FL and Hannig EM  (1996) Ligand interactions with eukaryotic translation initiation factor 2: role of the gamma-subunit. EMBO J 15(22):6311-20	SGD
IKI1/YHR187W	IDA: Inferred from Direct Assay Assigned on 2012-03-07	manually curated	Glatt S, et al.  (2012) The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase.LID - 10.1038/nsmb.2234 [doi] Nat Struct Mol Biol ()	SGD

tRNA binding      16 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ALA1/YOR335C	IEA: Inferred from Electronic Annotation with EBI:KW-0820 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ARC1/YGL105W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-08-07	manually curated	Galani K, et al.  (2001) The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p. EMBO J 20(23):6889-98	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002547 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0820 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CEX1/YOR112W	IDA: Inferred from Direct Assay Assigned on 2007-01-09	manually curated	McGuire AT and Mangroo D  (2007) Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery. EMBO J 26(2):288-300	SGD
DIS3/YOL021C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2009-02-03	manually curated	Schneider C, et al.  (2007) The exosome subunit Rrp44 plays a direct role in RNA substrate recognition. Mol Cell 27(2):324-31	SGD
FRS2/YFL022C	IEA: Inferred from Electronic Annotation with EBI:IPR002319 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
IFM1/YOL023W	IDA: Inferred from Direct Assay Assigned on 2008-11-20	manually curated	Garofalo C, et al.  (2003) Purification and characterization of yeast mitochondrial initiation factor 2. Arch Biochem Biophys 413(2):243-52	SGD
LHP1/YDL051W	IDA: Inferred from Direct Assay Assigned on 2009-09-21	manually curated	Ohira T, et al.  (2009) Precise analysis of modification status at various stage of tRNA maturation in Saccharomyces cerevisiae. Nucleic Acids Symp Ser (Oxf)(53):301-2	SGD
LOS1/YKL205W	TAS: Traceable Author Statement Assigned on 2002-09-17	manually curated	Feng W and Hopper AK  (2002) A Los1p-independent pathway for nuclear export of intronless tRNAs in Saccharomycescerevisiae. Proc Natl Acad Sci U S A 99(8):5412-7	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0820 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MRP4/YHL004W	ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	manually curated	Graack HR and Wittmann-Liebold B  (1998) Mitochondrial ribosomal proteins (MRPs) of yeast. Biochem J 329 ( Pt 3)():433-48	SGD
MSE1/YOL033W	IEA: Inferred from Electronic Annotation with EBI:IPR008925 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MSF1/YPR047W	IEA: Inferred from Electronic Annotation with EBI:IPR002319, EBI:IPR005121 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
NCL1/YBL024W	IEA: Inferred from Electronic Annotation with EBI:KW-0820 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
NCS6/YGL211W	IDA: Inferred from Direct Assay Assigned on 2010-11-16	manually curated	Leidel S, et al.  (2009) Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. Nature 458(7235):228-32	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0820 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
SLM3/YDL033C	IEA: Inferred from Electronic Annotation with EBI:KW-0820 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
TRM8/YDL201W	IEA: Inferred from Electronic Annotation with EBI:KW-0820 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
UTP8/YGR128C	IDA: Inferred from Direct Assay Assigned on 2009-04-24	manually curated	McGuire AT, et al.  (2009) Structural modeling identified the tRNA-binding domain of Utp8p, an essential nucleolar component of the nuclear tRNA export machinery of Saccharomyces cerevisiae. Biochem Cell Biol 87(2):431-43	SGD

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