GO term: ubiquitin-protein ligase activity 
Ontology: Molecular Function (GO:0004842)
Definition: Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Synonyms: E2; E3; ubiquitin activity; ubiquitin conjugating enzyme activity; ubiquitin ligase activity; ubiquitin protein ligase activity; ubiquitin protein-ligase activity; ubiquitin-conjugating enzyme activity; ubiquitin-ligase activity; ubiquitin:protein-lysine N-ligase (AMP-forming) activity; anaphase-promoting complex activity
View Ontology:
(graph) | 
(text)
Definition: Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Synonyms: E2; E3; ubiquitin activity; ubiquitin conjugating enzyme activity; ubiquitin ligase activity; ubiquitin protein ligase activity; ubiquitin protein-ligase activity; ubiquitin-conjugating enzyme activity; ubiquitin-ligase activity; ubiquitin:protein-lysine N-ligase (AMP-forming) activity; anaphase-promoting complex activity
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
ubiquitin-protein ligase activity (46 genes)
or to its variants containing one or more
qualifiers (40 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | contributes_to: ubiquitin-protein ligase activity | 40 |
| ubiquitin-protein ligase activity | 43 | |
| High-throughput | none | none |
| Computational (download data) | ubiquitin-protein ligase activity | 21 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
ubiquitin-protein ligase activity or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| ubiquitin-protein ligase activity 46 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| APC11/YDL008W | IDA: Inferred from Direct Assay Assigned on 2011-06-01 |
manually curated | Leverson JD, et al. (2000) The APC11 RING-H2 finger mediates E2-dependent ubiquitination. Mol Biol Cell 11(7):2315-25 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR024991 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| ASI1/YMR119W | IGI: Inferred from Genetic Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2001-08-24 |
manually curated | Forsberg H, et al. (2001) Suppressors of ssy1 and ptr3 null mutations define novel amino acid sensor-independent genes in Saccharomyces cerevisiae. Genetics 158(3):973-88 |
SGD |
| ASI3/YNL008C | IGI: Inferred from Genetic Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2001-08-24 |
manually curated | Forsberg H, et al. (2001) Suppressors of ssy1 and ptr3 null mutations define novel amino acid sensor-independent genes in Saccharomyces cerevisiae. Genetics 158(3):973-88 |
SGD |
| ASR1/YPR093C | IDA: Inferred from Direct Assay Assigned on 2008-12-17 |
manually curated | Daulny A, et al. (2008) Modulation of RNA polymerase II subunit composition by ubiquitylation. Proc Natl Acad Sci U S A 105(50):19649-54 |
SGD |
| BRE1/YDL074C | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2009-11-11 |
manually curated | Kim J and Roeder RG (2009) Direct Bre1-Paf1 Complex Interactions and RING Finger-independent Bre1-Rad6 Interactions Mediate Histone H2B Ubiquitylation in Yeast. J Biol Chem 284(31):20582-92 |
SGD |
| CDC34/YDR054C | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity with SGD:RAD6 Assigned on 2005-10-28 |
manually curated | Goebl MG, et al. (1988) The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science 241(4871):1331-5 |
SGD |
| IEA: Inferred from Electronic Annotation with IUBMB:6.3.2.19 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB | |
| CUL3/YGR003W | IDA: Inferred from Direct Assay Assigned on 2003-07-08 |
manually curated | Michel JJ, et al. (2003) A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression. J Biol Chem 278(25):22828-37 |
SGD |
| HEL1/YKR017C | IDA: Inferred from Direct Assay Assigned on 2012-11-02 |
manually curated | Singh RK, et al. (2012) Novel E3 Ubiquitin Ligases That Regulate Histone Protein Levels in the Budding Yeast Saccharomyces cerevisiae. PLoS One 7(5):e36295 |
SGD |
| HEL2/YDR266C | IDA: Inferred from Direct Assay Assigned on 2012-11-02 |
manually curated | Singh RK, et al. (2012) Novel E3 Ubiquitin Ligases That Regulate Histone Protein Levels in the Budding Yeast Saccharomyces cerevisiae. PLoS One 7(5):e36295 |
SGD |
| HRD1/YOL013C | IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction with SGD:UBC7 Assigned on 2008-01-17 |
manually curated | Deak PM and Wolf DH (2001) Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem 276(14):10663-9 |
SGD |
| IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction with SGD:UBC7, SGD:UBC1, IMP: Inferred from Mutant Phenotype Assigned on 2001-07-05 |
manually curated | Bays NW, et al. (2001) Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol 3(1):24-9 |
SGD | |
| HUL4/YJR036C | ISS: Inferred from Sequence or structural Similarity with SGD:RSP5 Assigned on 2012-05-11 |
manually curated | Wang G, et al. (1999) Functional domains of the Rsp5 ubiquitin-protein ligase. Mol Cell Biol 19(1):342-52 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR000569 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IBA: Inferred from Biological Aspect of Ancestor with PANTHER:PTHR11254_AN0 Assigned on 2011-02-04 |
computational | Gaudet P, et al. (2011) Annotation inferences using phylogenetic trees. |
RefGenome | |
| HUL5/YGL141W | IEA: Inferred from Electronic Annotation with EBI:IPR000569 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| MMS2/YGL087C | ISS: Inferred from Sequence or structural Similarity with SGD:RAD6, SGD:UBC4 Assigned on 2005-10-28 |
manually curated | Broomfield S, et al. (1998) MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway. Proc Natl Acad Sci U S A 95(10):5678-83 |
SGD |
| ISS: Inferred from Sequence or structural Similarity Assigned on 2005-10-28 |
manually curated | Hofmann RM and Pickart CM (1999) Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 96(5):645-53 |
SGD | |
| MOT2/YER068W | IDA: Inferred from Direct Assay Assigned on 2006-12-20 |
manually curated | Panasenko O, et al. (2006) The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex. J Biol Chem 281(42):31389-98 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2009-04-21 |
manually curated | Mersman DP, et al. (2009) Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes Dev 23(8):951-62 |
SGD | |
| PEP5/YMR231W | IDA: Inferred from Direct Assay Assigned on 2012-11-02 |
manually curated | Singh RK, et al. (2012) Novel E3 Ubiquitin Ligases That Regulate Histone Protein Levels in the Budding Yeast Saccharomyces cerevisiae. PLoS One 7(5):e36295 |
SGD |
| PEX10/YDR265W | IDA: Inferred from Direct Assay Assigned on 2008-08-21 |
manually curated | Williams C, et al. (2008) Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p. Biochem Biophys Res Commun 374(4):620-4 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2010-07-21 |
manually curated | Platta HW, et al. (2009) Pex2 and pex12 function as protein-ubiquitin ligases in peroxisomal protein import. Mol Cell Biol 29(20):5505-16 |
SGD | |
| PEX12/YMR026C | IDA: Inferred from Direct Assay Assigned on 2010-07-21 |
manually curated | Platta HW, et al. (2009) Pex2 and pex12 function as protein-ubiquitin ligases in peroxisomal protein import. Mol Cell Biol 29(20):5505-16 |
SGD |
| PEX2/YJL210W | IDA: Inferred from Direct Assay Assigned on 2010-07-21 |
manually curated | Platta HW, et al. (2009) Pex2 and pex12 function as protein-ubiquitin ligases in peroxisomal protein import. Mol Cell Biol 29(20):5505-16 |
SGD |
| PEX4/YGR133W | ISS: Inferred from Sequence or structural Similarity with SGD:RAD6, SGD:CDC34, SGD:UBC4, SGD:UBC8 Assigned on 2005-10-27 |
manually curated | Wiebel FF and Kunau WH (1992) The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes. Nature 359(6390):73-6 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2007-06-20 |
manually curated | Platta HW, et al. (2007) Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling. J Cell Biol 177(2):197-204 |
SGD | |
| IEA: Inferred from Electronic Annotation with IUBMB:6.3.2.19 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB | |
| PIB1/YDR313C | IDA: Inferred from Direct Assay Assigned on 2002-08-22 |
manually curated | Shin ME, et al. (2001) FYVE domain targets Pib1p ubiquitin ligase to endosome and vacuolar membranes. J Biol Chem 276(44):41388-93 |
SGD |
| PRP19/YLL036C | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2009-10-20 |
manually curated | Ohi MD, et al. (2003) Structural insights into the U-box, a domain associated with multi-ubiquitination. Nat Struct Biol 10(4):250-5 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR003613 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| PSH1/YOL054W | IDA: Inferred from Direct Assay Assigned on 2011-01-21 |
manually curated | Ranjitkar P, et al. (2010) An E3 Ubiquitin Ligase Prevents Ectopic Localization of the Centromeric Histone H3 Variant via the Centromere Targeting Domain. Mol Cell 40(3):455-64 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2011-01-21 |
manually curated | Hewawasam G, et al. (2010) Psh1 Is an E3 Ubiquitin Ligase that Targets the Centromeric Histone Variant Cse4. Mol Cell 40(3):444-54 |
SGD | |
| RAD18/YCR066W | IPI: Inferred from Physical Interaction with SGD:RAD6 Assigned on 2009-11-11 |
manually curated | Bailly V, et al. (1994) Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites. Genes Dev 8(7):811-20 |
SGD |
| IPI: Inferred from Physical Interaction with SGD:POL30 Assigned on 2009-11-11 |
manually curated | Hoege C, et al. (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419(6903):135-41 |
SGD | |
| RAD6/YGL058W | IDA: Inferred from Direct Assay Assigned on 2005-10-28 |
manually curated | Jentsch S, et al. (1987) The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. Nature 329(6135):131-4 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2002-08-06 |
manually curated | Bailly V, et al. (1997) Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities. J Biol Chem 272(37):23360-5 |
SGD | |
| IEA: Inferred from Electronic Annotation with IUBMB:6.3.2.19 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB | |
| RKR1/YMR247C | IDA: Inferred from Direct Assay Assigned on 2007-02-12 |
manually curated | Braun MA, et al. (2007) Identification of Rkr1, a nuclear RING domain protein with functional connections to chromatin modification in Saccharomyces cerevisiae. Mol Cell Biol 27(8):2800-11 |
SGD |
| RMD5/YDR255C | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2011-12-16 |
manually curated | Santt O, et al. (2008) The Yeast GID Complex, a Novel Ubiquitin Ligase (E3) Involved in the Regulation of Carbohydrate Metabolism. Mol Biol Cell 19(8):3323-33 |
SGD |
| RSP5/YER125W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2008-10-13 |
manually curated | Huibregtse JM, et al. (1997) The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase. Proc Natl Acad Sci U S A 94(8):3656-61 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR024928, EBI:IPR000569 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| RTT101/YJL047C | IDA: Inferred from Direct Assay Assigned on 2003-07-08 |
manually curated | Michel JJ, et al. (2003) A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression. J Biol Chem 278(25):22828-37 |
SGD |
| SAN1/YDR143C | IDA: Inferred from Direct Assay Assigned on 2004-09-05 |
manually curated | Dasgupta A, et al. (2004) Sir Antagonist 1 (San1) is a ubiquitin ligase. J Biol Chem 279(26):26830-8 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2008-01-16 |
manually curated | Gardner RG, et al. (2005) Degradation-mediated protein quality control in the nucleus. Cell 120(6):803-15 |
SGD | |
| SLX8/YER116C | IDA: Inferred from Direct Assay Assigned on 2007-09-21 |
manually curated | Xie Y, et al. (2007) The Yeast Hex3{middle dot}Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation. J Biol Chem 282(47):34176-84 |
SGD |
| contributes_to: ubiquitin-protein ligase activity 40 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| APC1/YNL172W | IMP: Inferred from Mutant Phenotype Assigned on 2011-06-01 |
manually curated | Thornton BR, et al. (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60 |
SGD |
| APC2/YLR127C | IMP: Inferred from Mutant Phenotype Assigned on 2011-06-01 |
manually curated | Thornton BR, et al. (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60 |
SGD |
| APC4/YDR118W | IDA: Inferred from Direct Assay Assigned on 2011-06-06 |
manually curated | Thornton BR, et al. (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60 |
SGD |
| APC5/YOR249C | IDA: Inferred from Direct Assay Assigned on 2011-06-06 |
manually curated | Thornton BR, et al. (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60 |
SGD |
| APC9/YLR102C | IDA: Inferred from Direct Assay Assigned on 2011-06-06 |
manually curated | Passmore LA, et al. (2003) Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J 22(4):786-96 |
SGD |
| CDC16/YKL022C | IMP: Inferred from Mutant Phenotype Assigned on 2011-11-14 |
manually curated | Thornton BR, et al. (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60 |
SGD |
| CDC23/YHR166C | IMP: Inferred from Mutant Phenotype Assigned on 2011-11-14 |
manually curated | Thornton BR, et al. (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60 |
SGD |
| CDC26/YFR036W | IMP: Inferred from Mutant Phenotype Assigned on 2011-11-14 |
manually curated | Zachariae W, et al. (1996) Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science 274(5290):1201-4 |
SGD |
| CDC27/YBL084C | IMP: Inferred from Mutant Phenotype Assigned on 2011-11-14 |
manually curated | Thornton BR, et al. (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60 |
SGD |
| CDC34/YDR054C | IDA: Inferred from Direct Assay Assigned on 2007-02-05 |
manually curated | Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2007-02-07 |
manually curated | Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30 |
SGD | |
| CDC36/YDL165W | IMP: Inferred from Mutant Phenotype Assigned on 2006-12-20 |
manually curated | Panasenko O, et al. (2006) The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex. J Biol Chem 281(42):31389-98 |
SGD |
| CDC4/YFL009W | IDA: Inferred from Direct Assay Assigned on 2007-02-05 |
manually curated | Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2007-02-07 |
manually curated | Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30 |
SGD | |
| CDC53/YDL132W | IDA: Inferred from Direct Assay Assigned on 2007-02-21 |
manually curated | Seol JH, et al. (1999) Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34. Genes Dev 13(12):1614-26 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2007-02-05 |
manually curated | Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 |
SGD | |
| IDA: Inferred from Direct Assay Assigned on 2007-02-07 |
manually curated | Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30 |
SGD | |
| DAS1/YJL149W | ISA: Inferred from Sequence Alignment with SGD:GRR1, SGD:CDC4, SGD:MDM30, SGD:DIA2 Assigned on 2011-03-18 |
manually curated | Patton EE, et al. (1998) Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet 14(6):236-43 |
SGD |
| ISA: Inferred from Sequence Alignment with SGD:GRR1, SGD:CDC4, SGD:MDM30, SGD:DIA2 Assigned on 2011-03-18 |
manually curated | Willems AR, et al. (1999) SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis. Philos Trans R Soc Lond B Biol Sci 354(1389):1533-50 |
SGD | |
| DIA2/YOR080W | IDA: Inferred from Direct Assay Assigned on 2009-11-23 |
manually curated | Mimura S, et al. (2009) SCF(Dia2) regulates DNA replication forks during S-phase in budding yeast. EMBO J 28(23):3693-705 |
SGD |
| DMA1/YHR115C | IDA: Inferred from Direct Assay Assigned on 2008-03-10 |
manually curated | Loring GL, et al. (2008) Yeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-dependent ubiquitination. Cell Cycle 7(1):96-105 |
SGD |
| DMA2/YNL116W | IDA: Inferred from Direct Assay Assigned on 2008-03-10 |
manually curated | Loring GL, et al. (2008) Yeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-dependent ubiquitination. Cell Cycle 7(1):96-105 |
SGD |
| ELA1/YNL230C | IMP: Inferred from Mutant Phenotype Assigned on 2011-08-25 |
manually curated | Ribar B, et al. (2007) ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells. Mol Cell Biol 27(8):3211-6 |
SGD |
| ELC1/YPL046C | IDA: Inferred from Direct Assay Assigned on 2007-05-21 |
manually curated | Gillette TG, et al. (2006) Distinct functions of the ubiquitin-proteasome pathway influence nucleotide excision repair. EMBO J 25(11):2529-38 |
SGD |
| FYV10/YIL097W | IMP: Inferred from Mutant Phenotype Assigned on 2011-12-16 |
manually curated | Braun B, et al. (2011) Gid9, a second RING finger protein contributes to the ubiquitin ligase activity of the Gid complex required for catabolite degradation. FEBS Lett 585(24):3856-61 |
SGD |
| GRR1/YJR090C | IDA: Inferred from Direct Assay Assigned on 2011-02-11 |
manually curated | Skowyra D, et al. (1999) Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. Science 284(5414):662-5 |
SGD |
| HRD3/YLR207W | IDA: Inferred from Direct Assay Assigned on 2008-08-14 |
manually curated | Gardner RG, et al. (2001) In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Mol Cell Biol 21(13):4276-91 |
SGD |
| HRT1/YOL133W | IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction with SGD:CDC4, SGD:CDC53, SGD:CDC34 Assigned on 2007-02-21 |
manually curated | Seol JH, et al. (1999) Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34. Genes Dev 13(12):1614-26 |
SGD |
| HRT3/YLR097C | ISA: Inferred from Sequence Alignment with SGD:CDC4, SGD:DIA2, SGD:GRR1, SGD:MDM30 Assigned on 2011-03-18 |
manually curated | Patton EE, et al. (1998) Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet 14(6):236-43 |
SGD |
| ISA: Inferred from Sequence Alignment with SGD:CDC4, SGD:DIA2, SGD:GRR1, SGD:MDM30 Assigned on 2011-03-18 |
manually curated | Willems AR, et al. (1999) SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis. Philos Trans R Soc Lond B Biol Sci 354(1389):1533-50 |
SGD | |
| MDM30/YLR368W | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:CDC53 Assigned on 2008-07-03 |
manually curated | Cohen MM, et al. (2008) Ubiquitin-Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion. Mol Biol Cell 19(6):2457-64 |
SGD |
| MMS2/YGL087C | IDA: Inferred from Direct Assay Assigned on 2005-10-28 |
manually curated | Hofmann RM and Pickart CM (1999) Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 96(5):645-53 |
SGD |
| NOT3/YIL038C | IMP: Inferred from Mutant Phenotype Assigned on 2006-12-20 |
manually curated | Panasenko O, et al. (2006) The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex. J Biol Chem 281(42):31389-98 |
SGD |
| NOT5/YPR072W | IMP: Inferred from Mutant Phenotype Assigned on 2006-12-20 |
manually curated | Panasenko O, et al. (2006) The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex. J Biol Chem 281(42):31389-98 |
SGD |
| RAD16/YBR114W | IDA: Inferred from Direct Assay Assigned on 2007-05-21 |
manually curated | Gillette TG, et al. (2006) Distinct functions of the ubiquitin-proteasome pathway influence nucleotide excision repair. EMBO J 25(11):2529-38 |
SGD |
| RAD7/YJR052W | IDA: Inferred from Direct Assay Assigned on 2007-05-21 |
manually curated | Gillette TG, et al. (2006) Distinct functions of the ubiquitin-proteasome pathway influence nucleotide excision repair. EMBO J 25(11):2529-38 |
SGD |
