Ontology: Molecular Function (GO:0004693)

Definition: Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).

Synonyms: ATP:cyclin phosphotransferase activity; cdc2 kinase activity; CDK; CDK activity; CDK, catalytic subunit activity; cdk-activating kinase activity; Cdk-activating protein kinase activity; cyclin D-cdk6 kinase activity; cyclin D-dependent kinase activity; cyclin E kinase activity; cyclin-A associated kinase activity; cyclin-dependent kinase 6 activity; cyclin-dependent kinase activity; cyclin-dependent kinase-2 activity; cyclin-dependent kinase-4 activity; cyclin-dependent protein kinase, intrinsic catalyst activity; D-type cyclin kinase activity; neuronal cdc2-like kinase activity; cyclin-dependent protein kinase activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term cyclin-dependent protein serine/threonine kinase activity (6 genes) or to its variants containing one or more qualifiers (2 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	contributes_to: cyclin-dependent protein serine/threonine kinase activity	2
	cyclin-dependent protein serine/threonine kinase activity	5
High-throughput	none	none
Computational (download data)	cyclin-dependent protein serine/threonine kinase activity	5

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term cyclin-dependent protein serine/threonine kinase activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

contributes_to: cyclin-dependent protein serine/threonine kinase activity      2 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CTK2/YJL006C	IPI: Inferred from Physical Interaction with SGD:CTK1 Assigned on 2007-01-22	manually curated	Sterner DE, et al.  (1995) The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Mol Cell Biol 15(10):5716-24	SGD
CTK3/YML112W	IPI: Inferred from Physical Interaction with SGD:CTK1 Assigned on 2006-09-25	manually curated	Sterner DE, et al.  (1995) The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Mol Cell Biol 15(10):5716-24	SGD

cyclin-dependent protein serine/threonine kinase activity      6 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CAK1/YFL029C	IEA: Inferred from Electronic Annotation with IUBMB:2.7.11.22 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
CDC28/YBR160W	IDA: Inferred from Direct Assay Assigned on 2008-01-31	manually curated	Wittenberg C, et al.  (1990) G1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase. Cell 62(2):225-37	SGD
	IEA: Inferred from Electronic Annotation with IUBMB:2.7.11.22 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
CTK1/YKL139W	IDA: Inferred from Direct Assay Assigned on 2002-09-19	manually curated	Sterner DE, et al.  (1995) The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Mol Cell Biol 15(10):5716-24	SGD
PHO85/YPL031C	IDA: Inferred from Direct Assay Assigned on 2008-02-29	manually curated	Kaffman A, et al.  (1994) Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85. Science 263(5150):1153-6	SGD
	IDA: Inferred from Direct Assay Assigned on 2008-02-29	manually curated	Tan YS, et al.  (2003) Pho85 phosphorylates the Glc7 protein phosphatase regulator Glc8 in vivo. J Biol Chem 278(1):147-53	SGD
	IDA: Inferred from Direct Assay Assigned on 2008-02-29	manually curated	Huang D, et al.  (1998) Cyclin partners determine Pho85 protein kinase substrate specificity in vitro and in vivo: control of glycogen biosynthesis by Pcl8 and Pcl10. Mol Cell Biol 18(6):3289-99	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-10-19	manually curated	Huang D, et al.  (2009) Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast. PLoS Biol 7(9):e1000188	SGD
	IDA: Inferred from Direct Assay Assigned on 2008-02-29	manually curated	Espinoza FH, et al.  (1994) Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85. Science 266(5189):1388-91	SGD
	IDA: Inferred from Direct Assay Assigned on 2008-02-29	manually curated	Measday V, et al.  (1994) The PCL2 (ORFD)-PHO85 cyclin-dependent kinase complex: a cell cycle regulator in yeast. Science 266(5189):1391-5	SGD
	IEA: Inferred from Electronic Annotation with IUBMB:2.7.11.22 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
SGV1/YPR161C	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction Assigned on 2002-09-30	manually curated	Yao S, et al.  (2000) BUR1 and BUR2 encode a divergent cyclin-dependent kinase-cyclin complex important for transcription in vivo. Mol Cell Biol 20(19):7080-7	SGD
	IEA: Inferred from Electronic Annotation with IUBMB:2.7.11.22 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
SSN3/YPL042C	ISS: Inferred from Sequence or structural Similarity with SGD:CDC28 Assigned on 2011-01-31	manually curated	Kuchin S, et al.  (1995) Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast. Proc Natl Acad Sci U S A 92(9):4006-10	SGD
	IDA: Inferred from Direct Assay Assigned on 2011-02-07	manually curated	Chi Y, et al.  (2001) Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes Dev 15(9):1078-92	SGD
	IEA: Inferred from Electronic Annotation with IUBMB:2.7.11.22 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB

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