GO term: protein serine/threonine kinase activity Help



Ontology: Molecular Function (GO:0004674)

Definition: Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Synonyms: A-kinase activity; AP50 kinase activity; ATP-protein transphosphorylase activity; ATP:protein phosphotransferase (non-specific) activity; betaIIPKC; calcium/phospholipid-dependent protein kinase activity; casein kinase (phosphorylating) activity; cytidine 3',5'-cyclic monophosphate-responsive protein kinase activity; dsk1; epsilon PKC; glycogen synthase A kinase activity; glycogen synthase kinase activity; HIPK2; Hpr kinase activity; hydroxyalkyl-protein kinase activity; M phase-specific cdc2 kinase activity; MAPK; mitogen-activated protein kinase activity; mitogen-activated S6 kinase activity; non-specific serine/threonine protein kinase activity; p82 kinase activity; phosphorylase B kinase kinase activity; phosphorylase b kinase kinase activity; PKA; PKC; protein glutamyl kinase activity; protein kinase (phosphorylating) activity; protein kinase A activity; protein kinase p58 activity; protein phosphokinase activity; protein serine kinase activity; protein serine-threonine kinase activity; protein-aspartyl kinase activity; protein-cysteine kinase activity; protein-serine kinase activity; Prp4 protein kinase activity; Raf kinase activity; Raf-1; ribosomal protein S6 kinase II activity; ribosomal S6 protein kinase activity; serine-specific protein kinase activity; serine kinase activity; serine protein kinase activity; serine(threonine) protein kinase activity; serine/threonine protein kinase activity; STK32; T-antigen kinase activity; threonine-specific protein kinase activity; twitchin kinase activity; Wee 1-like kinase activity; Wee-kinase activity; WEE1Hu; atypical PKC activity; glycogen synthase kinase 3 activity; atypical protein kinase C activity; galactosyltransferase-associated kinase activity

View Ontology: GO Tree Graph (graph) | Amigo (text)

Annotation Summary


This table lists the methods used to annotate genes either directly to the term protein serine/threonine kinase activity (125 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method GO Term # Yeast Genes Annotated
Manually curated (download data) protein serine/threonine kinase activity 54
High-throughput none none
Computational (download data) protein serine/threonine kinase activity 125

Links to Additional Annotations:
Genes Annotated with this Term
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Annotation details for genes that have been directly annotated to the term protein serine/threonine kinase activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

protein serine/threonine kinase activity
     125 genes directly annotated to this term
Locus Evidence Annotation Method Reference Assigned By
AKL1/YBR059C IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALK1/YGL021W ISS: Inferred from Sequence or structural Similarity
with GenBank/EMBL/DDBJ:AAK30301.1
Assigned on 2006-10-31
manually curated Higgins JM  (2003) Structure, function and evolution of haspin and haspin-related proteins, a distinctive group of eukaryotic protein kinases. Cell Mol Life Sci 60(3):446-62 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALK2/YBL009W ISS: Inferred from Sequence or structural Similarity
with GenBank/EMBL/DDBJ:AAK30301.1
Assigned on 2003-05-27
manually curated Higgins JM  (2003) Structure, function and evolution of haspin and haspin-related proteins, a distinctive group of eukaryotic protein kinases. Cell Mol Life Sci 60(3):446-62 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ARK1/YNL020C IMP: Inferred from Mutant Phenotype,
ISS: Inferred from Sequence or structural Similarity
Assigned on 2001-01-18
manually curated Cope MJ, et al.  (1999) Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast. J Cell Biol 144(6):1203-18 SGD
IDA: Inferred from Direct Assay
Assigned on 2009-02-23
manually curated Jin M and Cai M  (2008) A Novel Function of Arp2p in Mediating Prk1p-specific Regulation of Actin and Endocytosis in Yeast. Mol Biol Cell 19(1):297-307 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ATG1/YGL180W IDA: Inferred from Direct Assay,
IMP: Inferred from Mutant Phenotype
Assigned on 2008-05-13
manually curated Matsuura A, et al.  (1997) Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene 192(2):245-50 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271, EBI:IPR022708
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
BCK1/YJL095W IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
BUB1/YGR188C IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
BUD32/YGR262C IDA: Inferred from Direct Assay
Assigned on 2002-10-10
manually curated Stocchetto S, et al.  (1997) Biochemical evidence that Saccharomyces cerevisiae YGR262c gene, required for normal growth, encodes a novel Ser/Thr-specific protein kinase. FEBS Lett 414(1):171-5 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CAK1/YFL029C IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CBK1/YNL161W IDA: Inferred from Direct Assay
Assigned on 2008-09-11
manually curated Mazanka E, et al.  (2008) The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry. PLoS Biol 6(8):e203 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271, EBI:IPR017892, EBI:IPR000961
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CDC15/YAR019C IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CDC28/YBR160W IDA: Inferred from Direct Assay
Assigned on 2012-12-10
manually curated Chymkowitch P, et al.  (2012) Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes. Proc Natl Acad Sci U S A 109(26):10450-5 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CDC5/YMR001C IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CDC7/YDL017W IMP: Inferred from Mutant Phenotype
Assigned on 2006-12-11
manually curated Hollingsworth RE Jr and Sclafani RA  (1990) DNA metabolism gene CDC7 from yeast encodes a serine (threonine) protein kinase. Proc Natl Acad Sci U S A 87(16):6272-6 SGD
IMP: Inferred from Mutant Phenotype
Assigned on 2006-12-11
manually curated Buck V, et al.  (1991) CDC7 protein kinase activity is required for mitosis and meiosis in Saccharomyces cerevisiae. Mol Gen Genet 227(3):452-7 SGD
IMP: Inferred from Mutant Phenotype
Assigned on 2006-12-11
manually curated Yoon HJ and Campbell JL  (1991) The CDC7 protein of Saccharomyces cerevisiae is a phosphoprotein that contains protein kinase activity. Proc Natl Acad Sci U S A 88(9):3574-8 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CHK1/YBR274W IDA: Inferred from Direct Assay
Assigned on 2007-08-21
manually curated Wang H, et al.  (2001) Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Genes Dev 15(11):1361-72 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CKA1/YIL035C IDA: Inferred from Direct Assay
Assigned on 2007-07-25
manually curated Bojanowski K, et al.  (1993) DNA topoisomerase II and casein kinase II associate in a molecular complex that is catalytically active. J Biol Chem 268(30):22920-6 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CKA2/YOR061W IDA: Inferred from Direct Assay
Assigned on 2007-07-25
manually curated Bojanowski K, et al.  (1993) DNA topoisomerase II and casein kinase II associate in a molecular complex that is catalytically active. J Biol Chem 268(30):22920-6 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CLA4/YNL298W IDA: Inferred from Direct Assay,
IPI: Inferred from Physical Interaction
with SGD:FUS2
Assigned on 2013-03-06
manually curated Kim J and Rose MD  (2012) A mechanism for the coordination of proliferation and differentiation by spatial regulation of Fus2p in budding yeast. Genes Dev 26(10):1110-21 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CMK1/YFR014C IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CMK2/YOL016C IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
COQ8/YGL119W IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
CTK1/YKL139W IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
DBF2/YGR092W IDA: Inferred from Direct Assay
Assigned on 2004-08-06
manually curated Toyn JH and Johnston LH  (1994) The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition. EMBO J 13(5):1103-13 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271, EBI:IPR017892, EBI:IPR000961
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
DBF20/YPR111W IDA: Inferred from Direct Assay
Assigned on 2002-11-18
manually curated Toyn JH and Johnston LH  (1994) The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition. EMBO J 13(5):1103-13 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271, EBI:IPR017892, EBI:IPR000961
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
DUN1/YDL101C IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ELM1/YKL048C IDA: Inferred from Direct Assay
Assigned on 2003-05-08
manually curated Koehler CM and Myers AM  (1997) Serine-threonine protein kinase activity of Elm1p, a regulator of morphologic differentiation in Saccharomyces cerevisiae. FEBS Lett 408(1):109-14 SGD
IDA: Inferred from Direct Assay
Assigned on 2007-08-14
manually curated Hong SP, et al.  (2003) Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci U S A 100(15):8839-43 SGD
IDA: Inferred from Direct Assay
Assigned on 2007-08-14
manually curated Elbing K, et al.  (2006) Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae. Biochem J 393(Pt 3):797-805 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ENV7/YPL236C ISS: Inferred from Sequence or structural Similarity
with GenBank/EMBL/DDBJ:AAC98502.1
Assigned on 2006-11-13
manually curated Stairs DB, et al.  (1998) Cloning and characterization of Krct, a member of a novel subfamily of serine/threonine kinases. Hum Mol Genet 7(13):2157-66 SGD
ISS: Inferred from Sequence or structural Similarity
with GenBank/EMBL/DDBJ:AJ005790
Assigned on 2006-11-13
manually curated Ligos JM, et al.  (1998) Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases. Biochem Biophys Res Commun 249(2):380-4 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
FMP48/YGR052W IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
FPK1/YNR047W IDA: Inferred from Direct Assay,
IMP: Inferred from Mutant Phenotype
Assigned on 2009-12-15
manually curated Roelants FM, et al.  (2010) A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci U S A 107(1):34-9 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008271, EBI:IPR000961
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
FRK1/YPL141C IEA: Inferred from Electronic Annotation
with EBI:IPR008271
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0723
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB