Ontology: Molecular Function (GO:0004672)

Definition: Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

Synonyms: protamine kinase activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term protein kinase activity (126 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	protein kinase activity	46
High-throughput (download data)	protein kinase activity	82
Computational (download data)	protein kinase activity	117

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term protein kinase activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

protein kinase activity      126 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
AKL1/YBR059C	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-09-25	manually curated	Cope MJ, et al.  (1999) Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast. J Cell Biol 144(6):1203-18	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ALK1/YGL021W	IDA: Inferred from Direct Assay Assigned on 2006-10-31	manually curated	Nespoli A, et al.  (2006) Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast. Cell Cycle 5(13):1464-71	SGD
ALK2/YBL009W	IDA: Inferred from Direct Assay Assigned on 2006-10-31	manually curated	Nespoli A, et al.  (2006) Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast. Cell Cycle 5(13):1464-71	SGD
ARK1/YNL020C	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ATG1/YGL180W	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719, EBI:IPR002290 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BCK1/YJL095W	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719, EBI:IPR002290 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BUB1/YGR188C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Roberts BT, et al.  (1994) The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol Cell Biol 14(12):8282-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BUD32/YGR262C	IEA: Inferred from Electronic Annotation with EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CAK1/YFL029C	IEA: Inferred from Electronic Annotation with EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CBK1/YNL161W	IEA: Inferred from Electronic Annotation with EBI:IPR002290, EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CDC15/YAR019C	IDA: Inferred from Direct Assay Assigned on 2002-09-18	manually curated	Mah AS, et al.  (2001) Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex. Proc Natl Acad Sci U S A 98(13):7325-30	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719, EBI:IPR002290 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CDC28/YBR160W	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719, EBI:IPR002290 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CDC5/YMR001C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2006-12-07	manually curated	Kitada K, et al.  (1993) A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5. Mol Cell Biol 13(7):4445-57	SGD
	IDA: Inferred from Direct Assay Assigned on 2006-06-12	manually curated	Geymonat M, et al.  (2003) In vitro regulation of budding yeast Bfa1/Bub2 GAP activity by Cdc5. J Biol Chem 278(17):14591-4	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2006-12-05	manually curated	Darieva Z, et al.  (2006) Polo kinase controls cell-cycle-dependent transcription by targeting a coactivator protein. Nature 444(7118):494-8	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002290, EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CDC7/YDL017W	IEA: Inferred from Electronic Annotation with EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CHK1/YBR274W	IEA: Inferred from Electronic Annotation with EBI:IPR000719, EBI:IPR002290 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CKA1/YIL035C	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CKA2/YOR061W	IEA: Inferred from Electronic Annotation with EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CLA4/YNL298W	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719, EBI:IPR002290 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CMK1/YFR014C	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719, EBI:IPR002290 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CMK2/YOL016C	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719, EBI:IPR002290 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CTK1/YKL139W	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719, EBI:IPR002290 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
DBF2/YGR092W	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002290, EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
DBF20/YPR111W	IEA: Inferred from Electronic Annotation with EBI:IPR002290, EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
DUN1/YDL101C	IDA: Inferred from Direct Assay Assigned on 2002-11-12	manually curated	Zhao X and Rothstein R  (2002) The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1. Proc Natl Acad Sci U S A 99(6):3746-51	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719, EBI:IPR002290 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ELM1/YKL048C	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ENV7/YPL236C	IEA: Inferred from Electronic Annotation with EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
FMP48/YGR052W	ISM: Inferred from Sequence Model Assigned on 2011-04-01	manually curated	Miranda-Saavedra D and Barton GJ  (2007) Classification and functional annotation of eukaryotic protein kinases. Proteins 68(4):893-914	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
FPK1/YNR047W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2008-11-10	manually curated	Nakano K, et al.  (2008) Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry. Mol Biol Cell 19(4):1783-97	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002290, EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
FRK1/YPL141C	ISS: Inferred from Sequence or structural Similarity with SGD:KIN4 Assigned on 2007-05-10	manually curated	D'Aquino KE, et al.  (2005) The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell 19(2):223-34	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002290, EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
FUS3/YBL016W	IDA: Inferred from Direct Assay Assigned on 2012-05-04	high-throughput	Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002290, EBI:IPR000719 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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