Ontology: Cellular Component (GO:0046540)

Definition: A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.

Synonyms: U4/U6.U5 snRNP complex

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term U4/U6 x U5 tri-snRNP complex (32 genes) or to its variants containing one or more qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	colocalizes_with: U4/U6 x U5 tri-snRNP complex	1
	U4/U6 x U5 tri-snRNP complex	32
High-throughput	none	none
Computational (download data)	U4/U6 x U5 tri-snRNP complex	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term U4/U6 x U5 tri-snRNP complex or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

U4/U6 x U5 tri-snRNP complex      32 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
SNU66/YOR308C	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SPP381/YBR152W	IDA: Inferred from Direct Assay Assigned on 2005-09-23	manually curated	Lybarger S, et al.  (1999) Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation. Mol Cell Biol 19(1):577-84	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD

colocalizes_with: U4/U6 x U5 tri-snRNP complex      1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
LIN1/YHR156C	IPI: Inferred from Physical Interaction Assigned on 2008-11-10	manually curated	Hacker I, et al.  (2008) Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nat Struct Mol Biol 15(11):1206-12	SGD

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