Ontology: Cellular Component (GO:0046540)

Definition: A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.

Synonyms: U4/U6.U5 snRNP complex

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term U4/U6 x U5 tri-snRNP complex (32 genes) or to its variants containing one or more qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	colocalizes_with: U4/U6 x U5 tri-snRNP complex	1
	U4/U6 x U5 tri-snRNP complex	32
High-throughput	none	none
Computational (download data)	U4/U6 x U5 tri-snRNP complex	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term U4/U6 x U5 tri-snRNP complex or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

U4/U6 x U5 tri-snRNP complex      32 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
BRR2/YER172C	IDA: Inferred from Direct Assay Assigned on 2007-08-23	manually curated	Lauber J, et al.  (1996) The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases. EMBO J 15(15):4001-15	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
DIB1/YPR082C	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
LSM2/YBL026W	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
LSM3/YLR438C-A	NAS: Non-traceable Author Statement Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
LSM4/YER112W	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
LSM5/YER146W	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
LSM6/YDR378C	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
LSM7/YNL147W	NAS: Non-traceable Author Statement Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
LSM8/YJR022W	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
PRP18/YGR006W	IDA: Inferred from Direct Assay Assigned on 2007-08-14	manually curated	Horowitz DS and Abelson J  (1993) A U5 small nuclear ribonucleoprotein particle protein involved only in the second step of pre-mRNA splicing in Saccharomyces cerevisiae. Mol Cell Biol 13(5):2959-70	SGD
PRP3/YDR473C	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR027104 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PRP31/YGR091W	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR027105 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PRP38/YGR075C	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2004-03-31	manually curated	Xie J, et al.  (1998) Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociation. EMBO J 17(10):2938-46	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
PRP4/YPR178W	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
PRP6/YBR055C	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
PRP8/YHR165C	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
	IDA: Inferred from Direct Assay Assigned on 2007-11-01	manually curated	Boon KL, et al.  (2007) prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast. Nat Struct Mol Biol 14(11):1077-83	SGD
SMB1/YER029C	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SMD1/YGR074W	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SMD2/YLR275W	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SMD3/YLR147C	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SME1/YOR159C	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SMX2/YFL017W-A	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SMX3/YPR182W	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SNR14/snR14	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-10-03	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SNR6/snR6	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-10-03	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SNR7-L/snR7-L	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-10-03	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SNR7-S/snR7-S	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-10-03	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SNU114/YKL173W	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SNU13/YEL026W	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD
SNU23/YDL098C	IDA: Inferred from Direct Assay Assigned on 2005-02-19	manually curated	Stevens SW and Abelson J  (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-09-26	manually curated	Gottschalk A, et al.  (1999) Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 18(16):4535-48	SGD

colocalizes_with: U4/U6 x U5 tri-snRNP complex      1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
LIN1/YHR156C	IPI: Inferred from Physical Interaction Assigned on 2008-11-10	manually curated	Hacker I, et al.  (2008) Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nat Struct Mol Biol 15(11):1206-12	SGD

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