Ontology: Biological Process (GO:0046020)

Definition: Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.

Synonyms: down regulation of transcription from RNA polymerase II promoter by pheromones; down-regulation of transcription from RNA polymerase II promoter by pheromones; downregulation of transcription from RNA polymerase II promoter by pheromones; inhibition of transcription from RNA polymerase II promoter by pheromones; negative regulation of transcription from Pol II promoter by pheromones

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This table lists the methods used to annotate genes either directly to the term negative regulation of transcription from RNA polymerase II promoter by pheromones (9 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	negative regulation of transcription from RNA polymerase II promoter by pheromones	9
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term negative regulation of transcription from RNA polymerase II promoter by pheromones or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

negative regulation of transcription from RNA polymerase II promoter by pheromones      9 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
DIG1/YPL049C	IGI: Inferred from Genetic Interaction with SGD:DIG2 Assigned on 2010-11-08	manually curated	Bardwell L, et al.  (1998) Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins. Proc Natl Acad Sci U S A 95(26):15400-5	SGD
	IGI: Inferred from Genetic Interaction with SGD:DIG2 Assigned on 2010-11-08	manually curated	Tedford K, et al.  (1997) Regulation of the mating pheromone and invasive growth responses in yeast by two MAP kinase substrates. Curr Biol 7(4):228-38	SGD
DIG2/YDR480W	IGI: Inferred from Genetic Interaction with SGD:DIG1 Assigned on 2010-11-08	manually curated	Bardwell L, et al.  (1998) Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins. Proc Natl Acad Sci U S A 95(26):15400-5	SGD
	IGI: Inferred from Genetic Interaction with SGD:DIG1 Assigned on 2010-11-08	manually curated	Tedford K, et al.  (1997) Regulation of the mating pheromone and invasive growth responses in yeast by two MAP kinase substrates. Curr Biol 7(4):228-38	SGD
HOG1/YLR113W	IEP: Inferred from Expression Pattern Assigned on 2007-02-08	manually curated	Rep M, et al.  (2000) The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes. J Biol Chem 275(12):8290-300	SGD
ISW2/YOR304W	IMP: Inferred from Mutant Phenotype Assigned on 2003-03-14	manually curated	Ruiz C, et al.  (2003) Cell-type-dependent repression of yeast a-specific genes requires Itc1p, a subunit of the Isw2p-Itc1p chromatin remodelling complex. Microbiology 149(Pt 2):341-51	SGD
ITC1/YGL133W	IMP: Inferred from Mutant Phenotype Assigned on 2003-03-14	manually curated	Ruiz C, et al.  (2003) Cell-type-dependent repression of yeast a-specific genes requires Itc1p, a subunit of the Isw2p-Itc1p chromatin remodelling complex. Microbiology 149(Pt 2):341-51	SGD
KAR4/YCL055W	IEP: Inferred from Expression Pattern Assigned on 2006-11-27	manually curated	Lahav R, et al.  (2007) Role of transcription factor Kar4 in regulating downstream events in the Saccharomyces cerevisiae pheromone response pathway. Mol Cell Biol 27(3):818-29	SGD
PRR1/YKL116C	IGI: Inferred from Genetic Interaction with SGD:STE11, SGD:STE12, IMP: Inferred from Mutant Phenotype Assigned on 2007-08-22	manually curated	Burchett SA, et al.  (2001) Identification of novel pheromone-response regulators through systematic overexpression of 120 protein kinases in yeast. J Biol Chem 276(28):26472-8	SGD
PRR2/YDL214C	IGI: Inferred from Genetic Interaction with SGD:STE11, SGD:STE12, IMP: Inferred from Mutant Phenotype Assigned on 2007-08-22	manually curated	Burchett SA, et al.  (2001) Identification of novel pheromone-response regulators through systematic overexpression of 120 protein kinases in yeast. J Biol Chem 276(28):26472-8	SGD
STE12/YHR084W	IMP: Inferred from Mutant Phenotype Assigned on 2011-04-13	manually curated	Bickel KS and Morris DR  (2006) Role of the transcription activator Ste12p as a repressor of PRY3 expression. Mol Cell Biol 26(21):7901-12	SGD

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