Ontology: Molecular Function (GO:0004602)

Definition: Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.

Synonyms: non-selenium glutathione peroxidase activity; glutathione:hydrogen-peroxide oxidoreductase activity; GSH peroxidase activity; reduced glutathione peroxidase activity; selenium-glutathione peroxidase activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term glutathione peroxidase activity (7 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	glutathione peroxidase activity	7
High-throughput	none	none
Computational (download data)	glutathione peroxidase activity	3

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term glutathione peroxidase activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

glutathione peroxidase activity      7 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
GPX1/YKL026C	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2006-06-01	manually curated	Inoue Y, et al.  (1999) Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae. J Biol Chem 274(38):27002-9	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-06-28	manually curated	Collinson EJ, et al.  (2002) The yeast glutaredoxins are active as glutathione peroxidases. J Biol Chem 277(19):16712-7	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000889 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with IUBMB:1.11.1.9 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
GPX2/YBR244W	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2006-06-01	manually curated	Inoue Y, et al.  (1999) Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae. J Biol Chem 274(38):27002-9	SGD
	IDA: Inferred from Direct Assay Assigned on 2002-09-28	manually curated	Avery AM and Avery SV  (2001) Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. J Biol Chem 276(36):33730-5	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-06-28	manually curated	Collinson EJ, et al.  (2002) The yeast glutaredoxins are active as glutathione peroxidases. J Biol Chem 277(19):16712-7	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000889 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with IUBMB:1.11.1.9 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
GRX1/YCL035C	IDA: Inferred from Direct Assay Assigned on 2003-07-02	manually curated	Collinson EJ and Grant CM  (2003) Role of yeast glutaredoxins as glutathione S-transferases. J Biol Chem 278(25):22492-7	SGD
	IDA: Inferred from Direct Assay Assigned on 2008-12-02	manually curated	Discola KF, et al.  (2009) Structural aspects of the distinct biochemical properties of glutaredoxin 1 and glutaredoxin 2 from Saccharomyces cerevisiae. J Mol Biol 385(3):889-901	SGD
GRX2/YDR513W	IDA: Inferred from Direct Assay Assigned on 2003-07-02	manually curated	Collinson EJ and Grant CM  (2003) Role of yeast glutaredoxins as glutathione S-transferases. J Biol Chem 278(25):22492-7	SGD
	IDA: Inferred from Direct Assay Assigned on 2008-12-02	manually curated	Discola KF, et al.  (2009) Structural aspects of the distinct biochemical properties of glutaredoxin 1 and glutaredoxin 2 from Saccharomyces cerevisiae. J Mol Biol 385(3):889-901	SGD
GTT1/YIR038C	IDA: Inferred from Direct Assay Assigned on 2007-01-04	manually curated	Garcera A, et al.  (2006) Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases. Biochem J 398(2):187-96	SGD
HYR1/YIR037W	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	manually curated	Inoue Y, et al.  (1999) Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae. J Biol Chem 274(38):27002-9	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000889 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
URE2/YNL229C	IDA: Inferred from Direct Assay Assigned on 2008-10-27	manually curated	Bai M, et al.  (2004) The yeast prion protein Ure2 shows glutathione peroxidase activity in both native and fibrillar forms. J Biol Chem 279(48):50025-30	SGD

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