Ontology: Biological Process (GO:0045944)

Definition: Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Synonyms: activation of global transcription from RNA polymerase II promoter; positive regulation of global transcription from Pol II promoter; stimulation of global transcription from RNA polymerase II promoter; up regulation of global transcription from RNA polymerase II promoter; up-regulation of global transcription from RNA polymerase II promoter; upregulation of global transcription from RNA polymerase II promoter; activation of transcription from RNA polymerase II promoter; positive regulation of transcription from Pol II promoter; stimulation of transcription from RNA polymerase II promoter; up regulation of transcription from RNA polymerase II promoter; up-regulation of transcription from RNA polymerase II promoter; upregulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter, global; positive regulation of gene-specific transcription from RNA polymerase II promoter

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term positive regulation of transcription from RNA polymerase II promoter (162 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	positive regulation of transcription from RNA polymerase II promoter	150
High-throughput (download data)	positive regulation of transcription from RNA polymerase II promoter	13
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term positive regulation of transcription from RNA polymerase II promoter or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

positive regulation of transcription from RNA polymerase II promoter      162 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ABF1/YKL112W	IMP: Inferred from Mutant Phenotype Assigned on 2005-10-20	manually curated	Miyake T, et al.  (2004) Genome-wide analysis of ARS (autonomously replicating sequence) binding factor 1 (Abf1p)-mediated transcriptional regulation in Saccharomyces cerevisiae. J Biol Chem 279(33):34865-72	SGD
ACA1/YER045C	IDA: Inferred from Direct Assay Assigned on 2011-08-04	manually curated	Garcia-Gimeno MA and Struhl K  (2000) Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress. Mol Cell Biol 20(12):4340-9	SGD
AFT1/YGL071W	IDA: Inferred from Direct Assay Assigned on 2004-12-14	manually curated	Fragiadakis GS, et al.  (2004) Nhp6 facilitates Aft1 binding and Ssn6 recruitment, both essential for FRE2 transcriptional activation. EMBO J 23(2):333-42	SGD
AFT2/YPL202C	IDA: Inferred from Direct Assay Assigned on 2012-01-05	manually curated	Blaiseau PL, et al.  (2001) Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem 276(36):34221-6	SGD
ARG80/YMR042W	IMP: Inferred from Mutant Phenotype Assigned on 2012-02-24	manually curated	Kovari LZ, et al.  (1993) Analysis of the inducer-responsive CAR1 upstream activation sequence (UASI) and the factors required for its operation. Yeast 9(8):835-45	SGD
ARG82/YDR173C	IMP: Inferred from Mutant Phenotype Assigned on 2007-12-19	manually curated	El Alami M, et al.  (2003) Arg82p is a bifunctional protein whose inositol polyphosphate kinase activity is essential for nitrogen and PHO gene expression but not for Mcm1p chaperoning in yeast. Mol Microbiol 49(2):457-68	SGD
ARO80/YDR421W	IMP: Inferred from Mutant Phenotype Assigned on 2003-05-07	manually curated	Iraqui I, et al.  (1999) Transcriptional induction by aromatic amino acids in Saccharomyces cerevisiae. Mol Cell Biol 19(5):3360-71	SGD
ARP7/YPR034W	IMP: Inferred from Mutant Phenotype Assigned on 2012-02-16	manually curated	Peterson CL, et al.  (1998) Subunits of the yeast SWI/SNF complex are members of the actin-related protein (ARP) family. J Biol Chem 273(37):23641-4	SGD
ARP9/YMR033W	IMP: Inferred from Mutant Phenotype Assigned on 2012-02-16	manually curated	Peterson CL, et al.  (1998) Subunits of the yeast SWI/SNF complex are members of the actin-related protein (ARP) family. J Biol Chem 273(37):23641-4	SGD
ASK10/YGR097W	IGI: Inferred from Genetic Interaction with SGD:SKN7, IMP: Inferred from Mutant Phenotype Assigned on 2012-01-04	manually curated	Page N, et al.  (1996) Identification of ASK10 as a multicopy activator of Skn7p-dependent transcription of a HIS3 reporter gene. Yeast 12(3):267-72	SGD
BAS1/YKR099W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2012-01-20	manually curated	Daignan-Fornier B and Fink GR  (1992) Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2. Proc Natl Acad Sci U S A 89(15):6746-50	SGD
	IGI: Inferred from Genetic Interaction with SGD:GCN4, SGD:PHO2, IMP: Inferred from Mutant Phenotype Assigned on 2012-01-20	manually curated	Arndt KT, et al.  (1987) Multiple global regulators control HIS4 transcription in yeast. Science 237(4817):874-80	SGD
BUD30/YDL151C	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-20	high-throughput	Enyenihi AH and Saunders WS  (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54	SGD
BUD32/YGR262C	IPI: Inferred from Physical Interaction with SGD:PCC1 Assigned on 2006-08-29	manually curated	Kisseleva-Romanova E, et al.  (2006) Yeast homolog of a cancer-testis antigen defines a new transcription complex. EMBO J 25(15):3576-85	SGD
BUR6/YER159C	IDA: Inferred from Direct Assay Assigned on 2007-02-08	manually curated	Cang Y and Prelich G  (2002) Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Proc Natl Acad Sci U S A 99(20):12727-32	SGD
CAD1/YDR423C	IDA: Inferred from Direct Assay Assigned on 2002-10-31	manually curated	Fernandes L, et al.  (1997) Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol 17(12):6982-93	SGD
CAM1/YPL048W	IMP: Inferred from Mutant Phenotype Assigned on 2007-08-24	manually curated	Hanbauer I, et al.  (2003) A homologue of elongation factor 1 gamma regulates methionine sulfoxide reductase A gene expression in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 100(14):8199-204	SGD
CBF1/YJR060W	IMP: Inferred from Mutant Phenotype Assigned on 2013-05-14	manually curated	McIsaac RS, et al.  (2012) Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway. Mol Biol Cell 23(15):2993-3007	SGD
CDC28/YBR160W	IMP: Inferred from Mutant Phenotype Assigned on 2012-12-10	manually curated	Chymkowitch P, et al.  (2012) Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes. Proc Natl Acad Sci U S A 109(26):10450-5	SGD
CEG1/YGL130W	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2004-12-13	manually curated	Kim HJ, et al.  (2004) mRNA capping enzyme activity is coupled to an early transcription elongation. Mol Cell Biol 24(14):6184-93	SGD
CGI121/YML036W	IPI: Inferred from Physical Interaction with SGD:PCC1 Assigned on 2006-08-29	manually curated	Kisseleva-Romanova E, et al.  (2006) Yeast homolog of a cancer-testis antigen defines a new transcription complex. EMBO J 25(15):3576-85	SGD
CRZ1/YNL027W	IGI: Inferred from Genetic Interaction with SGD:CNB1, IMP: Inferred from Mutant Phenotype Assigned on 2011-09-19	manually curated	Casado C, et al.  (2010) Regulation of Trk-dependent potassium transport by the calcineurin pathway involves the Hal5 kinase. FEBS Lett 584(11):2415-2420	SGD
CSE2/YNR010W	IMP: Inferred from Mutant Phenotype Assigned on 2011-07-18	manually curated	Han SJ, et al.  (1999) Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation. Mol Cell Biol 19(2):979-88	SGD
CST6/YIL036W	IDA: Inferred from Direct Assay Assigned on 2011-10-17	manually curated	Garcia-Gimeno MA and Struhl K  (2000) Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress. Mol Cell Biol 20(12):4340-9	SGD
EMI1/YDR512C	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-20	high-throughput	Enyenihi AH and Saunders WS  (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54	SGD
EMI2/YDR516C	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-20	high-throughput	Enyenihi AH and Saunders WS  (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54	SGD
EMI5/YOL071W	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-20	high-throughput	Enyenihi AH and Saunders WS  (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54	SGD
ESS1/YJR017C	IGI: Inferred from Genetic Interaction with SGD:SRB2, IPI: Inferred from Physical Interaction with SGD:RPO21 Assigned on 2011-06-15	manually curated	Wu X, et al.  (2000) The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. EMBO J 19(14):3727-38	SGD
GAL11/YOL051W	IDA: Inferred from Direct Assay Assigned on 2011-07-18	manually curated	Kim YJ, et al.  (1994) A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 77(4):599-608	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-07-18	manually curated	Han SJ, et al.  (1999) Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation. Mol Cell Biol 19(2):979-88	SGD
GCR1/YPL075W	IMP: Inferred from Mutant Phenotype Assigned on 2003-04-02	manually curated	Turkel S and Bisson LF  (1999) Transcription of the HXT4 gene is regulated by Gcr1p and Gcr2p in the yeast S. cerevisiae. Yeast 15(11):1045-57	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-06-20	manually curated	Uemura H, et al.  (1997) The role of Gcr1p in the transcriptional activation of glycolytic genes in yeast Saccharomyces cerevisiae. Genetics 147(2):521-32	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-06-20	manually curated	Sasaki H, et al.  (2005) Expression of GCR1, the transcriptional activator of glycolytic enzyme genes in the yeast Saccharomyces cerevisiae, is positively autoregulated by Gcr1p. Yeast 22(4):305-19	SGD
GCR2/YNL199C	IMP: Inferred from Mutant Phenotype Assigned on 2003-04-02	manually curated	Turkel S and Bisson LF  (1999) Transcription of the HXT4 gene is regulated by Gcr1p and Gcr2p in the yeast S. cerevisiae. Yeast 15(11):1045-57	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-06-20	manually curated	Uemura H, et al.  (1997) The role of Gcr1p in the transcriptional activation of glycolytic genes in yeast Saccharomyces cerevisiae. Genetics 147(2):521-32	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-06-20	manually curated	Sasaki H, et al.  (2005) Expression of GCR1, the transcriptional activator of glycolytic enzyme genes in the yeast Saccharomyces cerevisiae, is positively autoregulated by Gcr1p. Yeast 22(4):305-19	SGD

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