Ontology: Biological Process (GO:0045892)

Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-dependent transcription.

Synonyms: down regulation of gene-specific transcription; down-regulation of gene-specific transcription; downregulation of gene-specific transcription; inhibition of gene-specific transcription; down regulation of transcription, DNA-dependent; down-regulation of transcription, DNA-dependent; downregulation of transcription, DNA-dependent; inhibition of transcription, DNA-dependent; negative regulation of cellular transcription, DNA-dependent; negative regulation of gene-specific transcription; transcription repressor activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term negative regulation of transcription, DNA-dependent (6 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	negative regulation of transcription, DNA-dependent	3
High-throughput	none	none
Computational (download data)	negative regulation of transcription, DNA-dependent	3

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term negative regulation of transcription, DNA-dependent or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

negative regulation of transcription, DNA-dependent      6 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CDC28/YBR160W	IMP: Inferred from Mutant Phenotype Assigned on 2008-04-21	manually curated	Purnapatre K, et al.  (2002) The CLN3/SWI6/CLN2 pathway and SNF1 act sequentially to regulate meiotic initiation in Saccharomyces cerevisiae. Genes Cells 7(7):675-91	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2008-04-21	manually curated	Geymonat M, et al.  (2004) Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6. Mol Cell Biol 24(6):2277-85	SGD
EAF3/YPR023C	IMP: Inferred from Mutant Phenotype Assigned on 2008-03-12	manually curated	Joshi AA and Struhl K  (2005) Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation. Mol Cell 20(6):971-8	SGD
PEX14/YGL153W	IEA: Inferred from Electronic Annotation with EBI:IPR025655 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PST2/YDR032C	IEA: Inferred from Electronic Annotation with EBI:IPR010089 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SRG1	IEP: Inferred from Expression Pattern, IMP: Inferred from Mutant Phenotype Assigned on 2004-06-07	manually curated	Martens JA, et al.  (2004) Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene. Nature 429(6991):571-4	SGD
YCP4/YCR004C	IEA: Inferred from Electronic Annotation with EBI:IPR010089 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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