Ontology: Molecular Function (GO:0004558)

Definition: Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Synonyms: lysosomal alpha-glucosidase activity; acid maltase activity; alpha-glucosidase II; glucoinvertase activity; glucosidosucrase activity; maltase-glucoamylase activity; alpha-1,4-glucosidase activity; alpha-D-glucosidase activity; alpha-D-glucoside glucohydrolase activity; alpha-glucopyranosidase activity; glucosidoinvertase activity; alpha-glucoside hydrolase activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term alpha-glucosidase activity (6 genes) or to its variants containing one or more qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	alpha-glucosidase activity	5
	contributes_to: alpha-glucosidase activity	1
High-throughput	none	none
Computational (download data)	alpha-glucosidase activity	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term alpha-glucosidase activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

alpha-glucosidase activity      6 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
MAL12/YGR292W	IEA: Inferred from Electronic Annotation with IUBMB:3.2.1.20 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
MAL22	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-05-31	manually curated	Chow TH, et al.  (1989) Structure of the multigene family of MAL loci in Saccharomyces. Mol Gen Genet 217(1):60-9	SGD
MAL32/YBR299W	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-05-31	manually curated	Chow TH, et al.  (1989) Structure of the multigene family of MAL loci in Saccharomyces. Mol Gen Genet 217(1):60-9	SGD
	IEA: Inferred from Electronic Annotation with IUBMB:3.2.1.20 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
MAL42	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-05-31	manually curated	Chow TH, et al.  (1989) Structure of the multigene family of MAL loci in Saccharomyces. Mol Gen Genet 217(1):60-9	SGD
MAL62	IDA: Inferred from Direct Assay Assigned on 2003-03-17	manually curated	McCarter JD and Withers SG  (1996) Unequivocal identification of Asp-214 as the catalytic nucleophile of Saccharomyces cerevisiae alpha-glucosidase using 5-fluoro glycosyl fluorides. J Biol Chem 271(12):6889-94	SGD
ROT2/YBR229C	IDA: Inferred from Direct Assay Assigned on 2006-01-19	manually curated	Simons JF, et al.  (1998) Cell wall 1,6-beta-glucan synthesis in Saccharomyces cerevisiae depends on ER glucosidases I and II, and the molecular chaperone BiP/Kar2p. EMBO J 17(2):396-405	SGD

contributes_to: alpha-glucosidase activity      1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
GTB1/YDR221W	IMP: Inferred from Mutant Phenotype Assigned on 2006-01-19	manually curated	Wilkinson BM, et al.  (2006) Yeast GTB1 encodes a subunit of glucosidase II required for glycoprotein processing in the endoplasmic reticulum. J Biol Chem 281(10):6325-33	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2010-08-10	manually curated	Quinn RP, et al.  (2009) A novel role for Gtb1p in glucose trimming of N-linked glycans. Glycobiology 19(12):1408-16	SGD

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