Ontology: Molecular Function (GO:0004557)

Definition: Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase.

Synonyms: melibiase activity; alpha-D-galactosidase activity; alpha-D-galactoside galactohydrolase activity; alpha-galactosidase A; alpha-galactoside galactohydrolase activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term alpha-galactosidase activity (10 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	alpha-galactosidase activity	10
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term alpha-galactosidase activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

alpha-galactosidase activity      10 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
MEL1	IMP: Inferred from Mutant Phenotype Assigned on 2007-08-10	manually curated	Buckholz RG and Adams BG  (1981) Induction and genetics of two alpha-galactosidase activities in Saccharomyces cerevisiae. Mol Gen Genet 182(1):77-81	SGD
	IDA: Inferred from Direct Assay Assigned on 2007-08-10	manually curated	Post-Beittenmiller MA, et al.  (1984) Regulation of basal and induced levels of the MEL1 transcript in Saccharomyces cerevisiae. Mol Cell Biol 4(7):1238-45	SGD
MEL10	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-06-21	manually curated	Naumov G, et al.  (1991) Polymeric genes MEL8, MEL9 and MEL10--new members of alpha-galactosidase gene family in Saccharomyces cerevisiae. Curr Genet 20(4):269-76	SGD
MEL2	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-06-21	manually curated	Turakainen H, et al.  (1994) Consideration of the evolution of the Saccharomyces cerevisiae MEL gene family on the basis of the nucleotide sequences of the genes and their flanking regions. Yeast 10(12):1559-68	SGD
MEL3	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-07-08	manually curated	Naumov G, et al.  (1990) A new family of polymorphic genes in Saccharomyces cerevisiae: alpha-galactosidase genes MEL1-MEL7. Mol Gen Genet 224(1):119-28	SGD
MEL4	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-07-08	manually curated	Naumov G, et al.  (1990) A new family of polymorphic genes in Saccharomyces cerevisiae: alpha-galactosidase genes MEL1-MEL7. Mol Gen Genet 224(1):119-28	SGD
MEL5	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-12-04	manually curated	Naumov G, et al.  (1990) A new family of polymorphic genes in Saccharomyces cerevisiae: alpha-galactosidase genes MEL1-MEL7. Mol Gen Genet 224(1):119-28	SGD
MEL6	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-07-08	manually curated	Naumov G, et al.  (1990) A new family of polymorphic genes in Saccharomyces cerevisiae: alpha-galactosidase genes MEL1-MEL7. Mol Gen Genet 224(1):119-28	SGD
MEL7	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-07-08	manually curated	Naumov G, et al.  (1990) A new family of polymorphic genes in Saccharomyces cerevisiae: alpha-galactosidase genes MEL1-MEL7. Mol Gen Genet 224(1):119-28	SGD
MEL8	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-06-21	manually curated	Naumov G, et al.  (1991) Polymeric genes MEL8, MEL9 and MEL10--new members of alpha-galactosidase gene family in Saccharomyces cerevisiae. Curr Genet 20(4):269-76	SGD
MEL9	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-06-20	manually curated	Naumov G, et al.  (1991) Polymeric genes MEL8, MEL9 and MEL10--new members of alpha-galactosidase gene family in Saccharomyces cerevisiae. Curr Genet 20(4):269-76	SGD

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