Ontology: Molecular Function (GO:0004526)

Definition: Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor.

Synonyms: RNase P; tRNA 5' leader endonuclease activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term ribonuclease P activity (8 genes) or to its variants containing one or more qualifiers (12 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	contributes_to: ribonuclease P activity	12
High-throughput	none	none
Computational (download data)	ribonuclease P activity	8

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term ribonuclease P activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

contributes_to: ribonuclease P activity      12 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
POP1/YNL221C	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-16	manually curated	Xiao S, et al.  (2006) Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP. RNA 12(6):1023-37	SGD
POP3/YNL282W	IDA: Inferred from Direct Assay Assigned on 2006-11-21	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-21	manually curated	Dichtl B and Tollervey D  (1997) Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo. EMBO J 16(2):417-29	SGD
POP4/YBR257W	IDA: Inferred from Direct Assay Assigned on 2006-11-21	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-21	manually curated	Chu S, et al.  (1997) A novel protein shared by RNase MRP and RNase P. RNA 3(4):382-91	SGD
POP5/YAL033W	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-16	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP6/YGR030C	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-16	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP7/YBR167C	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-16	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP8/YBL018C	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-16	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
RPM1	IDA: Inferred from Direct Assay Assigned on 2007-02-26	manually curated	Dang YL and Martin NC  (1993) Yeast mitochondrial RNase P. Sequence of the RPM2 gene and demonstration that its product is a protein subunit of the enzyme. J Biol Chem 268(26):19791-6	SGD
RPM2/YML091C	IDA: Inferred from Direct Assay Assigned on 2007-02-26	manually curated	Dang YL and Martin NC  (1993) Yeast mitochondrial RNase P. Sequence of the RPM2 gene and demonstration that its product is a protein subunit of the enzyme. J Biol Chem 268(26):19791-6	SGD
RPP1/YHR062C	IDA: Inferred from Direct Assay Assigned on 2006-11-21	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-21	manually curated	Stolc V and Altman S  (1997) Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae. Genes Dev 11(21):2926-37	SGD
RPR1	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-21	manually curated	Lee JY, et al.  (1991) Characterization of RPR1, an essential gene encoding the RNA component of Saccharomyces cerevisiae nuclear RNase P. Mol Cell Biol 11(2):721-30	SGD
	IDA: Inferred from Direct Assay Assigned on 2006-11-21	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-01-21	manually curated	Hsieh J, et al.  (2009) Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release. RNA 15(2):224-34	SGD
RPR2/YIR015W	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-16	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-01-21	manually curated	Hsieh J, et al.  (2009) Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release. RNA 15(2):224-34	SGD

ribonuclease P activity      8 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
POP1/YNL221C	IEA: Inferred from Electronic Annotation with EBI:IPR012590, EBI:IPR009723 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.5 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
POP5/YAL033W	IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.5 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
POP6/YGR030C	IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.5 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
POP7/YBR167C	IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.5 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
POP8/YBL018C	IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.5 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
RPM2/YML091C	IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.5 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
RPP1/YHR062C	IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.5 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
RPR2/YIR015W	IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.5 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB

SGD Home About Blog Site Map Help Terms of Use
© Stanford University, Stanford, CA 94305.