GO term: ribonuclease H activity 
Ontology: Molecular Function (GO:0004523)
Definition: Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
Synonyms: calf thymus ribonuclease H activity; endoribonuclease0 H activity; ribonuclease H1 activity; ribonuclease H2 activity; ribonuclease H3 activity; RNase H activity; RNase H1 activity; RNase H2 activity; RNase H3 activity; endoribonuclease H; endoribonuclease H (calf thymus); hybrid nuclease activity; hybrid ribonuclease activity; hybridase (ribonuclease H); hybridase activity; RNA*DNA hybrid ribonucleotidohydrolase activity
View Ontology:
(graph) | 
(text)
Definition: Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
Synonyms: calf thymus ribonuclease H activity; endoribonuclease0 H activity; ribonuclease H1 activity; ribonuclease H2 activity; ribonuclease H3 activity; RNase H activity; RNase H1 activity; RNase H2 activity; RNase H3 activity; endoribonuclease H; endoribonuclease H (calf thymus); hybrid nuclease activity; hybrid ribonuclease activity; hybridase (ribonuclease H); hybridase activity; RNA*DNA hybrid ribonucleotidohydrolase activity
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
ribonuclease H activity (47 genes)
or to its variants containing one or more
qualifiers (2 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | contributes_to: ribonuclease H activity | 2 |
| ribonuclease H activity | 2 | |
| High-throughput | none | none |
| Computational (download data) | ribonuclease H activity | 47 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
ribonuclease H activity or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| ribonuclease H activity 47 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| RNH1/YMR234W | IDA: Inferred from Direct Assay Assigned on 2001-01-18 |
manually curated | Cerritelli SM and Crouch RJ (1995) The non-RNase H domain of Saccharomyces cerevisiae RNase H1 binds double-stranded RNA: magnesium modulates the switch between double-stranded RNA binding and RNase H activity. RNA 1(3):246-59 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR017067, EBI:IPR002156 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB | |
| RNH201/YNL072W | ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Frank P, et al. (1998) Yeast RNase H(35) is the counterpart of the mammalian RNase HI, and is evolutionarily related to prokaryotic RNase HII. FEBS Lett 421(1):23-6 |
SGD |
| IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2010-05-05 |
manually curated | Jeong HS, et al. (2004) RNase H2 of Saccharomyces cerevisiae is a complex of three proteins. Nucleic Acids Res 32(2):407-14 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR001352, EBI:IPR004649, EBI:IPR023160 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB | |
| YAR009C | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YBL005W-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YBL100W-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YBR012W-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YCL019W | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YDR034C-D | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YDR098C-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YDR210C-D | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YDR210W-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YDR261C-D | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YDR261W-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YDR316W-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YDR365W-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YER138C | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YER160C | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YFL002W-A | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YGR027W-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YGR038C-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YGR109W-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YGR161C-D | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YGR161W-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YHL009W-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YHR214C-B | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YIL082W-A | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YJL113W | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YJR027W | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YJR029W | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| YLR035C-A | IEA: Inferred from Electronic Annotation with IUBMB:3.1.26.4 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| contributes_to: ribonuclease H activity 2 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| RNH202/YDR279W | IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction with SGD:RNH203 Assigned on 2010-05-05 |
manually curated | Jeong HS, et al. (2004) RNase H2 of Saccharomyces cerevisiae is a complex of three proteins. Nucleic Acids Res 32(2):407-14 |
SGD |
| RNH203/YLR154C | IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction with SGD:RNH202 Assigned on 2010-05-05 |
manually curated | Jeong HS, et al. (2004) RNase H2 of Saccharomyces cerevisiae is a complex of three proteins. Nucleic Acids Res 32(2):407-14 |
SGD |
