Ontology: Molecular Function (GO:0045182)

Definition: Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.

Synonyms: translation factor activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term translation regulator activity (12 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	translation regulator activity	12
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term translation regulator activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

translation regulator activity      12 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
AEP1/YMR064W	IMP: Inferred from Mutant Phenotype Assigned on 2012-07-13	manually curated	Godard F, et al.  (2011) A genetic screen targeted on the FO component of mitochondrial ATP synthase in Saccharomyces cerevisiae. J Biol Chem 286(20):18181-9	SGD
ATP22/YDR350C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2010-03-17	manually curated	Zeng X, et al.  (2007) The Saccharomyces cerevisiae ATP22 gene codes for the mitochondrial ATPase subunit 6-specific translation factor. Genetics 175(1):55-63	SGD
CAF20/YOR276W	IGI: Inferred from Genetic Interaction, IPI: Inferred from Physical Interaction Assigned on 2002-11-18	manually curated	Ptushkina M, et al.  (1998) Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5' cap in yeast involves a site partially shared by p20. EMBO J 17(16):4798-808	SGD
CBS1/YDL069C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2011-02-04	manually curated	Rodel G and Fox TD  (1987) The yeast nuclear gene CBS1 is required for translation of mitochondrial mRNAs bearing the cob 5' untranslated leader. Mol Gen Genet 206(1):45-50	SGD
CBS2/YDR197W	IGI: Inferred from Genetic Interaction Assigned on 2011-02-04	manually curated	Rodel G  (1986) Two yeast nuclear genes, CBS1 and CBS2, are required for translation of mitochondrial transcripts bearing the 5'-untranslated COB leader. Curr Genet 11(1):41-5	SGD
GIS2/YNL255C	IDA: Inferred from Direct Assay Assigned on 2011-02-09	manually curated	Sammons MA, et al.  (2011) Saccharomyces cerevisiae Gis2 interacts with the translation machinery and is orthogonal to myotonic dystrophy type 2 protein ZNF9. Biochem Biophys Res Commun 406(1):13-9	SGD
MSS51/YLR203C	IMP: Inferred from Mutant Phenotype Assigned on 2009-11-18	manually curated	Perez-Martinez X, et al.  (2009) Dual Functions of Mss51 Couple Synthesis of Cox1 to Assembly of Cytochrome c Oxidase in Saccharomyces cerevisiae Mitochondria. Mol Biol Cell 20(20):4371-80	SGD
PET111/YMR257C	IMP: Inferred from Mutant Phenotype Assigned on 2003-02-10	manually curated	Poutre CG and Fox TD  (1987) PET111, a Saccharomyces cerevisiae nuclear gene required for translation of the mitochondrial mRNA encoding cytochrome c oxidase subunit II. Genetics 115(4):637-47	SGD
PET309/YLR067C	IGI: Inferred from Genetic Interaction Assigned on 2002-06-07	manually curated	Manthey GM and McEwen JE  (1995) The product of the nuclear gene PET309 is required for translation of mature mRNA and stability or production of intron-containing RNAs derived from the mitochondrial COX1 locus of Saccharomyces cerevisiae. EMBO J 14(16):4031-43	SGD
PET494/YNR045W	IMP: Inferred from Mutant Phenotype Assigned on 2003-02-10	manually curated	Costanzo MC and Fox TD  (1988) Specific translational activation by nuclear gene products occurs in the 5' untranslated leader of a yeast mitochondrial mRNA. Proc Natl Acad Sci U S A 85(8):2677-81	SGD
PET54/YGR222W	IMP: Inferred from Mutant Phenotype Assigned on 2003-02-10	manually curated	Costanzo MC, et al.  (1989) The PET54 gene of Saccharomyces cerevisiae: characterization of a nuclear gene encoding a mitochondrial translational activator and subcellular localization of its product. Genetics 122(2):297-305	SGD
YOR302W	IDA: Inferred from Direct Assay Assigned on 2003-02-12	manually curated	Wang Z, et al.  (1999) A highly conserved mechanism of regulated ribosome stalling mediated by fungal arginine attenuator peptides that appears independent of the charging status of arginyl-tRNAs. J Biol Chem 274(53):37565-74	SGD

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