GO term: glutamate-cysteine ligase activity

Ontology: Molecular Function (GO:0004357)

Definition: Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.

Synonyms: gamma-glutamyl-L-cysteine synthetase activity; gamma-glutamylcysteine synthetase activity; gamma-glutamylcysteinyl synthetase activity; L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity

Annotation Summary

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This table lists the methods used to annotate genes either directly to the term glutamate-cysteine ligase activity (1 gene) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	glutamate-cysteine ligase activity	1
High-throughput	none	none
Computational (download data)	glutamate-cysteine ligase activity	1

Links to Additional Annotations:

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Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Genes Annotated with this Term

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Annotation details for genes that have been directly annotated to the term glutamate-cysteine ligase activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

glutamate-cysteine ligase activity 1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
GSH1/YJL101C	IMP: Inferred from Mutant Phenotype Assigned on 2006-12-07	manually curated	Kistler M, et al. (1990) Genetic and biochemical analysis of glutathione-deficient mutants of Saccharomyces cerevisiae. Mutagenesis 5(1):39-44	SGD
	IDA: Inferred from Direct Assay Assigned on 2003-01-15	manually curated	Ohtake Y and Yabuuchi S (1991) Molecular cloning of the gamma-glutamylcysteine synthetase gene of Saccharomyces cerevisiae. Yeast 7(9):953-61	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR004308 Last Updated 2009-11-20	computational	DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms.	UniProtKB
	IEA: Inferred from Electronic Annotation with IUBMB:6.3.2.2 Last Updated 2009-11-20	computational	GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB

Graphical Display

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This diagram shows the local area of the Gene Ontology and the numbers of yeast genes annotated to each term in the diagram. Within the diagram, click on the blue arrow to navigate up the tree and click on a GO term name to go to its GO term page.

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