GO term: proteasome assembly 
Ontology: Biological Process (GO:0043248)
Definition: The aggregation, arrangement and bonding together of a mature, active proteasome complex.
Synonyms: proteasome complex assembly; proteasome maturation; 26S proteasome assembly
View Ontology:
(graph) | 
(text)
Definition: The aggregation, arrangement and bonding together of a mature, active proteasome complex.
Synonyms: proteasome complex assembly; proteasome maturation; 26S proteasome assembly
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
proteasome assembly (16 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | proteasome assembly | 16 |
| High-throughput | none | none |
| Computational | none | none |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
proteasome assembly or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| proteasome assembly 16 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ADD66/YKL206C | IGI: Inferred from Genetic Interaction with SGD:UMP1, SGD:PRE9, ISS: Inferred from Sequence or structural Similarity with GenBank/EMBL/DDBJ:FAA00023.1 Assigned on 2007-05-04 |
manually curated | Li X, et al. (2007) beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J 26(9):2339-49 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2008-10-24 |
manually curated | Scott CM, et al. (2007) ADD66, a Gene Involved in the Endoplasmic Reticulum-associated Degradation of {alpha}-1-Antitrypsin-Z in Yeast, Facilitates Proteasome Activity and Assembly. Mol Biol Cell 18(10):3776-87 |
SGD | |
| BLM10/YFL007W | IMP: Inferred from Mutant Phenotype Assigned on 2004-11-15 |
manually curated | Fehlker M, et al. (2003) Blm3 is part of nascent proteasomes and is involved in a late stage of nuclear proteasome assembly. EMBO Rep 4(10):959-63 |
SGD |
| IGI: Inferred from Genetic Interaction with SGD:RPN2, SGD:PRE4 Assigned on 2008-07-24 |
manually curated | Marques AJ, et al. (2007) The C-terminal Extension of the 7 Subunit and Activator Complexes Stabilize Nascent 20 S Proteasomes and Promote Their Maturation. J Biol Chem 282(48):34869-76 |
SGD | |
| ECM29/YHL030W | IDA: Inferred from Direct Assay Assigned on 2011-02-11 |
manually curated | Lehmann A, et al. (2010) Ecm29 fulfils quality control functions in proteasome assembly. Mol Cell 38(6):879-88 |
SGD |
| HSC82/YMR186W | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2005-01-11 |
manually curated | Imai J, et al. (2003) The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome. EMBO J 22(14):3557-67 |
SGD |
| HSP82/YPL240C | IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2005-01-11 |
manually curated | Imai J, et al. (2003) The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome. EMBO J 22(14):3557-67 |
SGD |
| IRC25/YLR021W | IGI: Inferred from Genetic Interaction with SGD:POC4, IMP: Inferred from Mutant Phenotype Assigned on 2007-11-05 |
manually curated | Le Tallec B, et al. (2007) 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Mol Cell 27(4):660-74 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2009-03-10 |
manually curated | Hoyt MA, et al. (2008) A genetic screen for Saccharomyces cerevisiae mutants affecting proteasome function, using a ubiquitin-independent substrate. Yeast 25(3):199-217 |
SGD | |
| IMP: Inferred from Mutant Phenotype Assigned on 2008-03-05 |
manually curated | Kusmierczyk AR, et al. (2008) A multimeric assembly factor controls the formation of alternative 20S proteasomes. Nat Struct Mol Biol 15(3):237-44 |
SGD | |
| NOB1/YOR056C | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2004-11-15 |
manually curated | Tone Y and Toh-E A (2002) Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae. Genes Dev 16(24):3142-57 |
SGD |
| PBA1/YLR199C | IGI: Inferred from Genetic Interaction with SGD:UMP1, SGD:PRE9, ISS: Inferred from Sequence or structural Similarity with GenBank/EMBL/DDBJ:FAA00022.1 Assigned on 2007-05-04 |
manually curated | Li X, et al. (2007) beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J 26(9):2339-49 |
SGD |
| POC4/YPL144W | IGI: Inferred from Genetic Interaction with SGD:IRC25, IMP: Inferred from Mutant Phenotype Assigned on 2007-11-05 |
manually curated | Le Tallec B, et al. (2007) 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Mol Cell 27(4):660-74 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2009-03-10 |
manually curated | Hoyt MA, et al. (2008) A genetic screen for Saccharomyces cerevisiae mutants affecting proteasome function, using a ubiquitin-independent substrate. Yeast 25(3):199-217 |
SGD | |
| IMP: Inferred from Mutant Phenotype Assigned on 2008-03-05 |
manually curated | Kusmierczyk AR, et al. (2008) A multimeric assembly factor controls the formation of alternative 20S proteasomes. Nat Struct Mol Biol 15(3):237-44 |
SGD | |
| PRE4/YFR050C | IGI: Inferred from Genetic Interaction with SGD:BLM10 Assigned on 2008-07-24 |
manually curated | Marques AJ, et al. (2007) The C-terminal Extension of the 7 Subunit and Activator Complexes Stabilize Nascent 20 S Proteasomes and Promote Their Maturation. J Biol Chem 282(48):34869-76 |
SGD |
| RPN2/YIL075C | IGI: Inferred from Genetic Interaction with SGD:BLM10 Assigned on 2008-07-24 |
manually curated | Marques AJ, et al. (2007) The C-terminal Extension of the 7 Subunit and Activator Complexes Stabilize Nascent 20 S Proteasomes and Promote Their Maturation. J Biol Chem 282(48):34869-76 |
SGD |
| RPN6/YDL097C | IMP: Inferred from Mutant Phenotype Assigned on 2009-03-03 |
manually curated | Santamaria PG, et al. (2003) Rpn6p, a proteasome subunit from Saccharomyces cerevisiae, is essential for the assembly and activity of the 26 S proteasome. J Biol Chem 278(9):6687-95 |
SGD |
| RPN9/YDR427W | IMP: Inferred from Mutant Phenotype Assigned on 2009-03-03 |
manually curated | Takeuchi J, et al. (1999) Rpn9 is required for efficient assembly of the yeast 26S proteasome. Mol Cell Biol 19(10):6575-84 |
SGD |
| SEM1/YDR363W-A | IMP: Inferred from Mutant Phenotype Assigned on 2009-03-06 |
manually curated | Le Tallec B, et al. (2009) Hsm3/S5b participates in the assembly pathway of the 19S regulatory particle of the proteasome. Mol Cell 33(3):389-99 |
SGD |
| SPG5/YMR191W | IMP: Inferred from Mutant Phenotype Assigned on 2013-02-11 |
manually curated | Hanna J, et al. (2012) Spg5 protein regulates the proteasome in quiescence. J Biol Chem 287(41):34400-9 |
SGD |
| UMP1/YBR173C | IMP: Inferred from Mutant Phenotype Assigned on 2004-11-15 |
manually curated | Ramos PC, et al. (1998) Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly. Cell 92(4):489-99 |
SGD |
| IGI: Inferred from Genetic Interaction with SGD:PRE7 Assigned on 2007-05-04 |
manually curated | Li X, et al. (2007) beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J 26(9):2339-49 |
SGD | |
