Ontology: Molecular Function (GO:0043115)

Definition: Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin.

Synonyms: siroheme synthase activity; 1,3-dimethyluroporphyrinogen III dehydrogenase activity; dihydrosirohydrochlorin dehydrogenase activity; precorrin-2 oxidase activity; CysG; Met8p; precorrin-2:NAD+ oxidoreductase activity; SirC

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term precorrin-2 dehydrogenase activity (2 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	precorrin-2 dehydrogenase activity	1
High-throughput	none	none
Computational (download data)	precorrin-2 dehydrogenase activity	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term precorrin-2 dehydrogenase activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

precorrin-2 dehydrogenase activity      2 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
MET1/YKR069W	IEA: Inferred from Electronic Annotation with EBI:IPR003043 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MET8/YBR213W	IDA: Inferred from Direct Assay Assigned on 2004-02-25	manually curated	Raux E, et al.  (1999) The role of Saccharomyces cerevisiae Met1p and Met8p in sirohaem and cobalamin biosynthesis. Biochem J 338 ( Pt 3)():701-8	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR006367 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with IUBMB:1.3.1.76 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB

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