Ontology: Molecular Function (GO:0043047)

Definition: Interacting selectively and non-covalently with single-stranded telomere-associated DNA.

Synonyms: telomeric ssDNA binding

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term single-stranded telomeric DNA binding (8 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	single-stranded telomeric DNA binding	8
High-throughput	none	none
Computational (download data)	single-stranded telomeric DNA binding	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term single-stranded telomeric DNA binding or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

single-stranded telomeric DNA binding      8 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CDC13/YDL220C	IDA: Inferred from Direct Assay Assigned on 2007-10-29	manually curated	Nugent CI, et al.  (1996) Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274(5285):249-52	SGD
	IDA: Inferred from Direct Assay Assigned on 2007-10-29	manually curated	Lin JJ and Zakian VA  (1996) The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. Proc Natl Acad Sci U S A 93(24):13760-5	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-10-29	manually curated	Lin YC, et al.  (2007) Genetic analysis reveals essential and non-essential amino acids within the telomeric DNA-binding interface of Cdc13p. Biochem J 403(2):289-95	SGD
IMP4/YNL075W	IDA: Inferred from Direct Assay Assigned on 2007-09-11	manually curated	Hsieh YC, et al.  (2007) The U3 small nucleolar ribonucleoprotein component Imp4p is a telomeric DNA-binding protein. Biochem J 408(3):387-93	SGD
MRE11/YMR224C	IDA: Inferred from Direct Assay Assigned on 2007-09-06	manually curated	Ghosal G and Muniyappa K  (2007) The Characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 Complex Reveals that Rad50 Negatively Regulates Mre11 Endonucleolytic but not the Exonucleolytic Activity. J Mol Biol 372(4):864-82	SGD
RAD50/YNL250W	IDA: Inferred from Direct Assay Assigned on 2007-09-06	manually curated	Ghosal G and Muniyappa K  (2007) The Characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 Complex Reveals that Rad50 Negatively Regulates Mre11 Endonucleolytic but not the Exonucleolytic Activity. J Mol Biol 372(4):864-82	SGD
STN1/YDR082W	IDA: Inferred from Direct Assay Assigned on 2007-10-29	manually curated	Gao H, et al.  (2007) RPA-like proteins mediate yeast telomere function. Nat Struct Mol Biol 14(3):208-14	SGD
SUA5/YGL169W	IDA: Inferred from Direct Assay Assigned on 2009-04-23	manually curated	Meng FL, et al.  (2009) Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication. EMBO J 28(10):1466-78	SGD
TEN1/YLR010C	IDA: Inferred from Direct Assay Assigned on 2007-10-29	manually curated	Gao H, et al.  (2007) RPA-like proteins mediate yeast telomere function. Nat Struct Mol Biol 14(3):208-14	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR024222 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
XRS2/YDR369C	IDA: Inferred from Direct Assay Assigned on 2007-09-06	manually curated	Ghosal G and Muniyappa K  (2007) The Characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 Complex Reveals that Rad50 Negatively Regulates Mre11 Endonucleolytic but not the Exonucleolytic Activity. J Mol Biol 372(4):864-82	SGD

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