Ontology: Molecular Function (GO:0043022)

Definition: Interacting selectively and non-covalently with any part of a ribosome.

Synonyms: ribosome receptor activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term ribosome binding (14 genes) or to its variants containing one or more qualifiers (3 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	contributes_to: ribosome binding	3
	ribosome binding	13
High-throughput	none	none
Computational (download data)	ribosome binding	4

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term ribosome binding or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

contributes_to: ribosome binding      3 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CBP3/YPL215W	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction with SGD:CBP6 Assigned on 2011-06-22	manually curated	Gruschke S, et al.  (2011) Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. J Cell Biol 193(6):1101-14	SGD
DOM34/YNL001W	IDA: Inferred from Direct Assay Assigned on 2011-10-06	manually curated	Becker T, et al.  (2011) Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome. Nat Struct Mol Biol 18(6):715-20	SGD
HBS1/YKR084C	IDA: Inferred from Direct Assay Assigned on 2011-10-06	manually curated	Becker T, et al.  (2011) Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome. Nat Struct Mol Biol 18(6):715-20	SGD

ribosome binding      14 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
AIM23/YJL131C	IDA: Inferred from Direct Assay Assigned on 2012-04-06	manually curated	Atkinson GC, et al.  (2012) Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae. Nucleic Acids Res 40(13):6122-34	SGD
ANB1/YJR047C	ISA: Inferred from Sequence Alignment with SGD:HYP2 Assigned on 2009-05-15	manually curated	Jao DL and Chen KY  (2006) Tandem affinity purification revealed the hypusine-dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex. J Cell Biochem 97(3):583-98	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR019769, EBI:IPR020189, EBI:IPR001884 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CBP6/YBR120C	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction with SGD:CBP3 Assigned on 2011-06-22	manually curated	Gruschke S, et al.  (2011) Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. J Cell Biol 193(6):1101-14	SGD
FUN12/YAL035W	IDA: Inferred from Direct Assay Assigned on 2011-03-23	manually curated	Shin BS, et al.  (2011) Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability. RNA 17(4):687-96	SGD
GUF1/YLR289W	IDA: Inferred from Direct Assay Assigned on 2008-09-03	manually curated	Bauerschmitt H, et al.  (2008) The Membrane-bound GTPase Guf1 Promotes Mitochondrial Protein Synthesis under Suboptimal Conditions. J Biol Chem 283(25):17139-46	SGD
	IEA: Inferred from Electronic Annotation with HAMAP:MF_03137 Last Updated 2013-03-02	computational	Swiss Institute of Bioinformatics (SIB) curators and GOA curators  (2006) Electronic Gene Ontology annotations created by transferring manual GO annotations between orthologous microbial proteins	UniProtKB
HYP2/YEL034W	IPI: Inferred from Physical Interaction Assigned on 2009-05-15	manually curated	Jao DL and Chen KY  (2006) Tandem affinity purification revealed the hypusine-dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex. J Cell Biochem 97(3):583-98	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001884, EBI:IPR019769, EBI:IPR020189 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MBA1/YBR185C	IDA: Inferred from Direct Assay Assigned on 2008-04-25	manually curated	Ott M, et al.  (2006) Mba1, a membrane-associated ribosome receptor in mitochondria. EMBO J 25(8):1603-10	SGD
MDM38/YOL027C	IDA: Inferred from Direct Assay Assigned on 2011-04-01	manually curated	Bauerschmitt H, et al.  (2010) Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. Mol Biol Cell 21(12):1937-44	SGD
MTG2/YHR168W	IDA: Inferred from Direct Assay Assigned on 2005-01-04	manually curated	Datta K, et al.  (2005) The yeast GTPase Mtg2p is required for mitochondrial translation and partially suppresses an rRNA methyltransferase mutant, mrm2. Mol Biol Cell 16(2):954-63	SGD
RKR1/YMR247C	IDA: Inferred from Direct Assay Assigned on 2010-11-19	manually curated	Bengtson MH and Joazeiro CA  (2010) Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature 467(7314):470-3	SGD
SNL1/YIL016W	IDA: Inferred from Direct Assay Assigned on 2012-06-14	manually curated	Verghese J and Morano KA  (2012) A lysine-rich region within fungal BAG domain-containing proteins mediates a novel association with ribosomes. Eukaryot Cell 11(8):1003-11	SGD
TIF6/YPR016C	IEA: Inferred from Electronic Annotation with EBI:IPR002769 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
TSA1/YML028W	IDA: Inferred from Direct Assay Assigned on 2008-04-02	manually curated	Trotter EW, et al.  (2008) The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant. Biochem J 412(1):73-80	SGD
YIH1/YCR059C	IDA: Inferred from Direct Assay Assigned on 2012-05-01	manually curated	Waller T, et al.  (2012) Evidence that Yih1 resides in a complex with ribosomes. FEBS J 279(10):1761-76	SGD

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