Ontology: Molecular Function (GO:0042626)

Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.

Synonyms: ABC transporter; ABC-type efflux permease activity; ABC-type efflux porter activity; ABC-type uptake permease activity; ATP binding cassette transporter; ATP-binding cassette (ABC) transporter activity; ATP-binding cassette transporter; mating pheromone exporter

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term ATPase activity, coupled to transmembrane movement of substances (24 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	ATPase activity, coupled to transmembrane movement of substances	11
High-throughput	none	none
Computational (download data)	ATPase activity, coupled to transmembrane movement of substances	21

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term ATPase activity, coupled to transmembrane movement of substances or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

ATPase activity, coupled to transmembrane movement of substances      24 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ADP1/YCR011C	ISS: Inferred from Sequence or structural Similarity with SGD:PXA2 Assigned on 2013-03-15	manually curated	Decottignies A and Goffeau A  (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15(2):137-45	SGD
ATM1/YMR301C	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	manually curated	Leighton J and Schatz G  (1995) An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeast. EMBO J 14(1):188-95	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR011527, EBI:IPR001140 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
AUS1/YOR011W	IEA: Inferred from Electronic Annotation with EBI:IPR010929 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BPT1/YLL015W	IEA: Inferred from Electronic Annotation with EBI:IPR001140, EBI:IPR011527 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MDL1/YLR188W	IEA: Inferred from Electronic Annotation with EBI:IPR011527, EBI:IPR001140 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MDL2/YPL270W	IEA: Inferred from Electronic Annotation with EBI:IPR011527, EBI:IPR001140 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
NFT1/YKR103W	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-11-20	manually curated	Decottignies A and Goffeau A  (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15(2):137-45	SGD
	ISS: Inferred from Sequence or structural Similarity Assigned on 2003-06-30	manually curated	Mason DL, et al.  (2003) A region within a lumenal loop of Saccharomyces cerevisiae Ycf1p directs proteolytic processing and substrate specificity. Eukaryot Cell 2(3):588-98	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR011527, EBI:IPR001140 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PDR10/YOR328W	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-10-03	manually curated	Wolfger H, et al.  (1997) The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. FEBS Lett 418(3):269-74	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR010929 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PDR11/YIL013C	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-09-18	manually curated	Rogers B, et al.  (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR010929 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PDR12/YPL058C	IEA: Inferred from Electronic Annotation with EBI:IPR010929 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PDR15/YDR406W	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-07-11	manually curated	Decottignies A and Goffeau A  (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15(2):137-45	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR010929 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PDR18/YNR070W	IEA: Inferred from Electronic Annotation with EBI:IPR010929 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PDR5/YOR153W	IEA: Inferred from Electronic Annotation with EBI:IPR010929 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PXA1/YPL147W	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-09-19	manually curated	Hettema EH, et al.  (1996) The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae. EMBO J 15(15):3813-22	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR011527 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PXA2/YKL188C	IDA: Inferred from Direct Assay Assigned on 2002-09-18	manually curated	Verleur N, et al.  (1997) Transport of activated fatty acids by the peroxisomal ATP-binding-cassette transporter Pxa2 in a semi-intact yeast cell system. Eur J Biochem 249(3):657-61	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR011527 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SNQ2/YDR011W	IEA: Inferred from Electronic Annotation with EBI:IPR010929 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
STE6/YKL209C	IEA: Inferred from Electronic Annotation with EBI:IPR011527, EBI:IPR001140 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
VMA8/YEL051W	IEA: Inferred from Electronic Annotation with EBI:IPR002699 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
VMR1/YHL035C	ISS: Inferred from Sequence or structural Similarity Assigned on 2003-07-06	manually curated	Gueldry O, et al.  (2003) Ycf1p-dependent Hg(II) detoxification in Saccharomyces cerevisiae. Eur J Biochem 270(11):2486-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR011527, EBI:IPR001140 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
YBT1/YLL048C	IEA: Inferred from Electronic Annotation with EBI:IPR011527, EBI:IPR001140 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
YCF1/YDR135C	IEA: Inferred from Electronic Annotation with EBI:IPR011527, EBI:IPR001140 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
YKR104W	ISS: Inferred from Sequence or structural Similarity Assigned on 2004-06-17	manually curated	Decottignies A and Goffeau A  (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15(2):137-45	SGD
	ISS: Inferred from Sequence or structural Similarity Assigned on 2004-06-17	manually curated	Mason DL, et al.  (2003) A region within a lumenal loop of Saccharomyces cerevisiae Ycf1p directs proteolytic processing and substrate specificity. Eukaryot Cell 2(3):588-98	SGD
YOL075C	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-11-20	manually curated	Decottignies A and Goffeau A  (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15(2):137-45	SGD
YOR1/YGR281W	IEA: Inferred from Electronic Annotation with EBI:IPR011527, EBI:IPR001140 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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