Ontology: Molecular Function (GO:0042623)

Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.

Synonyms: chaperonin ATPase activity; non-chaperonin molecular chaperone ATPase activity; peroxisome-assembly ATPase activity; nucleoplasmin ATPase activity; chaperonin; ATP phosphohydrolase (polypeptide-unfolding)

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term ATPase activity, coupled (4 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	ATPase activity, coupled	3
High-throughput	none	none
Computational (download data)	ATPase activity, coupled	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term ATPase activity, coupled or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

ATPase activity, coupled      4 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
HSC82/YMR186W	ISS: Inferred from Sequence or structural Similarity with SGD:HSP82 Assigned on 2006-06-13	manually curated	Borkovich KA, et al.  (1989) hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures. Mol Cell Biol 9(9):3919-30	SGD
HSP104/YLL026W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2009-02-13	manually curated	Bosl B, et al.  (2005) Substrate binding to the molecular chaperone Hsp104 and its regulation by nucleotides. J Biol Chem 280(46):38170-6	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2009-02-13	manually curated	Glover JR and Lindquist S  (1998) Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins. Cell 94(1):73-82	SGD
HSP82/YPL240C	IDA: Inferred from Direct Assay Assigned on 2003-03-18	manually curated	Richter K, et al.  (2002) N-terminal residues regulate the catalytic efficiency of the Hsp90 ATPase cycle. J Biol Chem 277(47):44905-10	SGD
PEX1/YKL197C	IEA: Inferred from Electronic Annotation with EBI:IPR025653 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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