Ontology: Biological Process (GO:0042276)

Definition: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.

Synonyms: mutagenic postreplication DNA repair; mutagenic PRR; error-prone postreplication DNA repair

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term error-prone translesion synthesis (11 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	error-prone translesion synthesis	11
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term error-prone translesion synthesis or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

error-prone translesion synthesis      11 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
DPB2/YPR175W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2012-09-26	manually curated	Sabouri N and Johansson E  (2009) Translesion synthesis of abasic sites by yeast DNA polymerase epsilon. J Biol Chem 284(46):31555-63	SGD
DPB3/YBR278W	IDA: Inferred from Direct Assay Assigned on 2012-09-26	manually curated	Sabouri N and Johansson E  (2009) Translesion synthesis of abasic sites by yeast DNA polymerase epsilon. J Biol Chem 284(46):31555-63	SGD
DPB4/YDR121W	IDA: Inferred from Direct Assay Assigned on 2012-09-26	manually curated	Sabouri N and Johansson E  (2009) Translesion synthesis of abasic sites by yeast DNA polymerase epsilon. J Biol Chem 284(46):31555-63	SGD
POL2/YNL262W	IDA: Inferred from Direct Assay Assigned on 2012-09-26	manually curated	Sabouri N and Johansson E  (2009) Translesion synthesis of abasic sites by yeast DNA polymerase epsilon. J Biol Chem 284(46):31555-63	SGD
RAD18/YCR066W	IGI: Inferred from Genetic Interaction with SGD:REV3 Assigned on 2009-11-11	manually curated	Huang ME, et al.  (2002) Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase delta, suppresses genomic deletions and is involved in the mutagenic bypass pathway. Genetics 160(4):1409-22	SGD
	IGI: Inferred from Genetic Interaction with SGD:REV3, SGD:RAD1 Assigned on 2009-11-11	manually curated	Minesinger BK and Jinks-Robertson S  (2005) Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae. Genetics 169(4):1939-55	SGD
RAD30/YDR419W	IDA: Inferred from Direct Assay Assigned on 2010-01-19	manually curated	Yuan F, et al.  (2000) Specificity of DNA lesion bypass by the yeast DNA polymerase eta. J Biol Chem 275(11):8233-9	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2010-01-19	manually curated	Bresson A and Fuchs RP  (2002) Lesion bypass in yeast cells: Pol eta participates in a multi-DNA polymerase process. EMBO J 21(14):3881-7	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2010-01-19	manually curated	Abdulovic AL and Jinks-Robertson S  (2006) The in Vivo Characterization of Translesion Synthesis Across UV-Induced Lesions in Saccharomyces cerevisiae: Insights Into Pol{zeta}- and Pol{eta}-Dependent Frameshift Mutagenesis. Genetics 172(3):1487-98	SGD
RAD5/YLR032W	IMP: Inferred from Mutant Phenotype Assigned on 2012-12-11	manually curated	Kuang L, et al.  (2013) A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5. DNA Repair (Amst) 12(1):27-37	SGD
RAD6/YGL058W	IGI: Inferred from Genetic Interaction with SGD:REV3 Assigned on 2009-11-11	manually curated	Lawrence CW and Christensen R  (1976) UV mutagenesis in radiation-sensitive strains of yeast. Genetics 82(2):207-32	SGD
REV1/YOR346W	IGI: Inferred from Genetic Interaction with SGD:APN1, SGD:APN2 Assigned on 2010-02-02	manually curated	Johnson RE, et al.  (1998) Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Genes Dev 12(19):3137-43	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-02-02	manually curated	Nelson JR, et al.  (1996) Deoxycytidyl transferase activity of yeast REV1 protein. Nature 382(6593):729-31	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2010-02-02	manually curated	Lemontt JF  (1971) Mutants of yeast defective in mutation induced by ultraviolet light. Genetics 68(1):21-33	SGD
REV3/YPL167C	IGI: Inferred from Genetic Interaction with SGD:APN1, SGD:APN2 Assigned on 2010-02-02	manually curated	Johnson RE, et al.  (1998) Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Genes Dev 12(19):3137-43	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-02-02	manually curated	Lemontt JF  (1971) Mutants of yeast defective in mutation induced by ultraviolet light. Genetics 68(1):21-33	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-02-02	manually curated	Johnson RE, et al.  (2001) Role of DNA polymerase zeta in the bypass of a (6-4) TT photoproduct. Mol Cell Biol 21(10):3558-63	SGD
REV7/YIL139C	IGI: Inferred from Genetic Interaction with SGD:APN1, SGD:APN2 Assigned on 2010-02-02	manually curated	Johnson RE, et al.  (1998) Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Genes Dev 12(19):3137-43	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2010-02-02	manually curated	Lawrence CW, et al.  (1985) UV and chemical mutagenesis in rev7 mutants of yeast. Mol Gen Genet 200(1):86-91	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-02-02	manually curated	Johnson RE, et al.  (2001) Role of DNA polymerase zeta in the bypass of a (6-4) TT photoproduct. Mol Cell Biol 21(10):3558-63	SGD

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