Ontology: Biological Process (GO:0042144)

Definition: The fusion of two vacuole membranes to form a single vacuole.

Synonyms: homotypic vacuole fusion (non-autophagic); homotypic vacuole fusion, non-autophagic; vacuole fusion (non-autophagic); homotypic vacuole fusion

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term vacuole fusion, non-autophagic (32 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	vacuole fusion, non-autophagic	32
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term vacuole fusion, non-autophagic or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

vacuole fusion, non-autophagic      32 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
BPT1/YLL015W	IMP: Inferred from Mutant Phenotype Assigned on 2013-05-15	manually curated	Sasser TL, et al.  (2013) The Yeast ABC Transporter Ycf1p Enhances the Recruitment of the Soluble SNARE Vam7p to Vacuoles for Efficient Membrane Fusion. J Biol Chem ()	SGD
CLN3/YAL040C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2004-06-14	manually curated	Han BK, et al.  (2003) The G1 cyclin Cln3p controls vacuolar biogenesis in Saccharomyces cerevisiae. Genetics 165(2):467-76	SGD
CMD1/YBR109C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2005-05-03	manually curated	Peters C and Mayer A  (1998) Ca2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion. Nature 396(6711):575-80	SGD
IVY1/YDR229W	IGI: Inferred from Genetic Interaction with SGD:VPS33, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:VPS33, SGD:YPT7 Assigned on 2008-08-01	manually curated	Lazar T, et al.  (2002) A novel phospholipid-binding protein from the yeast Saccharomyces cerevisiae with dual binding specificities for the transport GTPase Ypt7p and the Sec1-related Vps33p. Eur J Cell Biol 81(12):635-46	SGD
NYV1/YLR093C	IDA: Inferred from Direct Assay Assigned on 2011-04-04	manually curated	Sato K and Wickner W  (1998) Functional reconstitution of ypt7p GTPase and a purified vacuole SNARE complex. Science 281(5377):700-2	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-04-20	manually curated	Fratti RA, et al.  (2007) Stringent 3Q.1R composition of the SNARE 0-layer can be bypassed for fusion by compensatory SNARE mutation or by lipid bilayer modification. J Biol Chem 282(20):14861-7	SGD
OPT2/YPR194C	IMP: Inferred from Mutant Phenotype Assigned on 2009-09-29	manually curated	Aouida M, et al.  (2009) Novel role for the Saccharomyces cerevisiae oligopeptide transporter Opt2 in drug detoxification. Biochem Cell Biol 87(4):653-61	SGD
PAH1/YMR165C	IMP: Inferred from Mutant Phenotype Assigned on 2012-05-09	manually curated	Sasser T, et al.  (2012) Yeast lipin 1 orthologue pah1p regulates vacuole homeostasis and membrane fusion. J Biol Chem 287(3):2221-36	SGD
PBI2/YNL015W	IDA: Inferred from Direct Assay Assigned on 2002-04-11	manually curated	Slusarewicz P, et al.  (1997) I2B is a small cytosolic protein that participates in vacuole fusion. Proc Natl Acad Sci U S A 94(11):5582-7	SGD
PEP3/YLR148W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2010-05-14	manually curated	Seals DF, et al.  (2000) A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc Natl Acad Sci U S A 97(17):9402-7	SGD
PEP5/YMR231W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2010-05-14	manually curated	Seals DF, et al.  (2000) A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc Natl Acad Sci U S A 97(17):9402-7	SGD
PFA3/YNL326C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2005-10-17	manually curated	Smotrys JE, et al.  (2005) The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. J Cell Biol 170(7):1091-9	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-10-10	manually curated	Hou H, et al.  (2005) The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8. Proc Natl Acad Sci U S A 102(48):17366-71	SGD
SEC17/YBL050W	IDA: Inferred from Direct Assay Assigned on 2011-04-04	manually curated	Sato K and Wickner W  (1998) Functional reconstitution of ypt7p GTPase and a purified vacuole SNARE complex. Science 281(5377):700-2	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-05-12	manually curated	Haas A and Wickner W  (1996) Homotypic vacuole fusion requires Sec17p (yeast alpha-SNAP) and Sec18p (yeast NSF). EMBO J 15(13):3296-305	SGD
SEC18/YBR080C	IDA: Inferred from Direct Assay Assigned on 2011-04-04	manually curated	Sato K and Wickner W  (1998) Functional reconstitution of ypt7p GTPase and a purified vacuole SNARE complex. Science 281(5377):700-2	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-05-12	manually curated	Haas A and Wickner W  (1996) Homotypic vacuole fusion requires Sec17p (yeast alpha-SNAP) and Sec18p (yeast NSF). EMBO J 15(13):3296-305	SGD
SWF1/YDR126W	IGI: Inferred from Genetic Interaction Assigned on 2005-10-17	manually curated	Smotrys JE, et al.  (2005) The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. J Cell Biol 170(7):1091-9	SGD
TRX1/YLR043C	IDA: Inferred from Direct Assay Assigned on 2002-04-11	manually curated	Xu Z, et al.  (1998) LMA1 binds to vacuoles at Sec18p (NSF), transfers upon ATP hydrolysis to a t-SNARE (Vam3p) complex, and is released during fusion. Cell 93(7):1125-34	SGD
TRX2/YGR209C	IDA: Inferred from Direct Assay Assigned on 2002-04-11	manually curated	Xu Z, et al.  (1998) LMA1 binds to vacuoles at Sec18p (NSF), transfers upon ATP hydrolysis to a t-SNARE (Vam3p) complex, and is released during fusion. Cell 93(7):1125-34	SGD
VAC8/YEL013W	IMP: Inferred from Mutant Phenotype Assigned on 2002-03-12	manually curated	Wang YX, et al.  (2001) Fusion of docked membranes requires the armadillo repeat protein Vac8p. J Biol Chem 276(37):35133-40	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-10-10	manually curated	Hou H, et al.  (2005) The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8. Proc Natl Acad Sci U S A 102(48):17366-71	SGD
VAM10/YOR068C	IMP: Inferred from Mutant Phenotype Assigned on 2003-08-08	manually curated	Kato M and Wickner W  (2003) Vam10p defines a Sec18p-independent step of priming that allows yeast vacuole tethering. Proc Natl Acad Sci U S A 100(11):6398-403	SGD
VAM3/YOR106W	IDA: Inferred from Direct Assay Assigned on 2011-04-04	manually curated	Sato K and Wickner W  (1998) Functional reconstitution of ypt7p GTPase and a purified vacuole SNARE complex. Science 281(5377):700-2	SGD
VAM6/YDL077C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2002-03-13	manually curated	Seals DF, et al.  (2000) A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc Natl Acad Sci U S A 97(17):9402-7	SGD
VAM7/YGL212W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-04-20	manually curated	Fratti RA, et al.  (2007) Stringent 3Q.1R composition of the SNARE 0-layer can be bypassed for fusion by compensatory SNARE mutation or by lipid bilayer modification. J Biol Chem 282(20):14861-7	SGD
VPS16/YPL045W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2010-05-14	manually curated	Seals DF, et al.  (2000) A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc Natl Acad Sci U S A 97(17):9402-7	SGD
VPS33/YLR396C	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-14	manually curated	Seals DF, et al.  (2000) A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc Natl Acad Sci U S A 97(17):9402-7	SGD
VPS41/YDR080W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2002-03-13	manually curated	Seals DF, et al.  (2000) A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc Natl Acad Sci U S A 97(17):9402-7	SGD
VTC1/YER072W	IMP: Inferred from Mutant Phenotype Assigned on 2002-07-15	manually curated	Muller O, et al.  (2002) The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation. EMBO J 21(3):259-69	SGD
VTC2/YFL004W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-07-15	manually curated	Muller O, et al.  (2002) The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation. EMBO J 21(3):259-69	SGD
VTC3/YPL019C	IMP: Inferred from Mutant Phenotype Assigned on 2002-07-15	manually curated	Muller O, et al.  (2002) The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation. EMBO J 21(3):259-69	SGD
VTC4/YJL012C	IMP: Inferred from Mutant Phenotype Assigned on 2002-07-15	manually curated	Muller O, et al.  (2002) The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation. EMBO J 21(3):259-69	SGD
VTI1/YMR197C	IMP: Inferred from Mutant Phenotype Assigned on 2011-04-06	manually curated	Ungermann C, et al.  (1999) Three v-SNAREs and two t-SNAREs, present in a pentameric cis-SNARE complex on isolated vacuoles, are essential for homotypic fusion. J Cell Biol 145(7):1435-42	SGD
YCF1/YDR135C	IMP: Inferred from Mutant Phenotype Assigned on 2013-05-15	manually curated	Sasser TL, et al.  (2013) The Yeast ABC Transporter Ycf1p Enhances the Recruitment of the Soluble SNARE Vam7p to Vacuoles for Efficient Membrane Fusion. J Biol Chem ()	SGD

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