GO term: aspartic-type endopeptidase activity 
Ontology: Molecular Function (GO:0004190)
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
Synonyms: aspartic endopeptidase activity; aspartic protease activity; aspartyl protease activity; carboxyl protease activity; aspartate protease activity
View Ontology:
(graph) | 
(text)
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
Synonyms: aspartic endopeptidase activity; aspartic protease activity; aspartyl protease activity; carboxyl protease activity; aspartate protease activity
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
aspartic-type endopeptidase activity (55 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | aspartic-type endopeptidase activity | 8 |
| High-throughput | none | none |
| Computational (download data) | aspartic-type endopeptidase activity | 55 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
aspartic-type endopeptidase activity or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| aspartic-type endopeptidase activity 55 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| BAR1/YIL015W | IMP: Inferred from Mutant Phenotype Assigned on 2007-09-19 |
manually curated | MacKay VL, et al. (1988) The Saccharomyces cerevisiae BAR1 gene encodes an exported protein with homology to pepsin. Proc Natl Acad Sci U S A 85(1):55-9 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2007-09-19 |
manually curated | Ballensiefen W and Schmitt HD (1997) Periplasmic Bar1 protease of Saccharomyces cerevisiae is active before reaching its extracellular destination. Eur J Biochem 247(1):142-7 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR001461, EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| DDI1/YER143W | ISA: Inferred from Sequence Alignment with EBI:Q9BQI9 Assigned on 2011-03-30 |
manually curated | Krylov DM and Koonin EV (2001) A novel family of predicted retroviral-like aspartyl proteases with a possible key role in eukaryotic cell cycle control. Curr Biol 11(15):R584-7 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR001995, EBI:IPR019103 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| MKC7/YDR144C | IDA: Inferred from Direct Assay Assigned on 2002-09-30 |
manually curated | Komano H, et al. (1999) Purification and characterization of the yeast glycosylphosphatidylinositol-anchored, monobasic-specific aspartyl protease yapsin 2 (Mkc7p). J Biol Chem 274(34):24431-7 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR001461, EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| PEP4/YPL154C | IEA: Inferred from Electronic Annotation with EBI:IPR001461, EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YBL005W-B | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YBL100W-B | IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| YBR012W-B | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YCL019W | IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| YDR034C-D | IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| YDR098C-B | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YDR210C-D | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YDR210W-B | IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| YDR261C-D | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YDR261W-B | IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| YDR316W-B | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YDR365W-B | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YER138C | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YER160C | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YFL002W-A | IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| YGL258W-A | IEA: Inferred from Electronic Annotation with EBI:IPR001461 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| YGR027W-B | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YGR038C-B | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YGR109W-B | IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| YGR161C-D | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YGR161W-B | IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| YHL009W-B | IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| YHR214C-B | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| YIL082W-A | IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| YJL113W | IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| YJR027W | IEA: Inferred from Electronic Annotation with EBI:IPR001969 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0064 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
