GO term: GTPase activity 
Ontology: Molecular Function (GO:0003924)
Definition: Catalysis of the reaction: GTP + H2O = GDP + phosphate.
Synonyms: ARF small monomeric GTPase activity; dynamin GTPase activity; heterotrimeric G-protein GTPase activity; heterotrimeric G-protein GTPase, alpha-subunit; heterotrimeric G-protein GTPase, beta-subunit; heterotrimeric G-protein GTPase, gamma-subunit; hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement; protein-synthesizing GTPase activity; protein-synthesizing GTPase activity, elongation; protein-synthesizing GTPase activity, initiation; protein-synthesizing GTPase activity, termination; Rab small monomeric GTPase activity; Ran small monomeric GTPase activity; Ras small monomeric GTPase activity; RHEB small monomeric GTPase activity; Rho small monomeric GTPase activity; Sar small monomeric GTPase activity; signal-recognition-particle GTPase activity; small monomeric GTPase activity; tubulin GTPase activity
View Ontology:
(graph) | 
(text)
Definition: Catalysis of the reaction: GTP + H2O = GDP + phosphate.
Synonyms: ARF small monomeric GTPase activity; dynamin GTPase activity; heterotrimeric G-protein GTPase activity; heterotrimeric G-protein GTPase, alpha-subunit; heterotrimeric G-protein GTPase, beta-subunit; heterotrimeric G-protein GTPase, gamma-subunit; hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement; protein-synthesizing GTPase activity; protein-synthesizing GTPase activity, elongation; protein-synthesizing GTPase activity, initiation; protein-synthesizing GTPase activity, termination; Rab small monomeric GTPase activity; Ran small monomeric GTPase activity; Ras small monomeric GTPase activity; RHEB small monomeric GTPase activity; Rho small monomeric GTPase activity; Sar small monomeric GTPase activity; signal-recognition-particle GTPase activity; small monomeric GTPase activity; tubulin GTPase activity
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
GTPase activity (73 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | GTPase activity | 58 |
| High-throughput | none | none |
| Computational (download data) | GTPase activity | 37 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
GTPase activity or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| GTPase activity 73 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ARF1/YDL192W | IDA: Inferred from Direct Assay Assigned on 2007-03-29 |
manually curated | Poon PP, et al. (1996) Saccharomyces cerevisiae Gcs1 is an ADP-ribosylation factor GTPase-activating protein. Proc Natl Acad Sci U S A 93(19):10074-7 |
SGD |
| ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Sewell JL and Kahn RA (1988) Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins. Proc Natl Acad Sci U S A 85(13):4620-4 |
SGD | |
| ARF2/YDL137W | IDA: Inferred from Direct Assay Assigned on 2007-03-29 |
manually curated | Poon PP, et al. (1996) Saccharomyces cerevisiae Gcs1 is an ADP-ribosylation factor GTPase-activating protein. Proc Natl Acad Sci U S A 93(19):10074-7 |
SGD |
| ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Stearns T, et al. (1990) ADP ribosylation factor is an essential protein in Saccharomyces cerevisiae and is encoded by two genes. Mol Cell Biol 10(12):6690-9 |
SGD | |
| ARF3/YOR094W | ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Lee FJ, et al. (1994) Characterization of a glucose-repressible ADP-ribosylation factor 3 (ARF3) from Saccharomyces cerevisiae. J Biol Chem 269(33):20931-7 |
SGD |
| ARL1/YBR164C | IDA: Inferred from Direct Assay, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-05-29 |
manually curated | Lee FJ, et al. (1997) Characterization of an ADP-ribosylation factor-like 1 protein in Saccharomyces cerevisiae. J Biol Chem 272(49):30998-1005 |
SGD |
| ARL3/YPL051W | IDA: Inferred from Direct Assay, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-05-29 |
manually curated | Huang CF, et al. (1999) Characterization of a novel ADP-ribosylation factor-like protein (yARL3) in Saccharomyces cerevisiae. J Biol Chem 274(6):3819-27 |
SGD |
| BMS1/YPL217C | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2009-05-22 |
manually curated | Karbstein K, et al. (2005) An essential GTPase promotes assembly of preribosomal RNA processing complexes. Mol Cell 20(4):633-43 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR000795 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| CDC10/YCR002C | IDA: Inferred from Direct Assay Assigned on 2004-12-10 |
manually curated | Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 |
SGD |
| CDC12/YHR107C | IDA: Inferred from Direct Assay Assigned on 2004-12-10 |
manually curated | Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 |
SGD |
| CDC42/YLR229C | IDA: Inferred from Direct Assay Assigned on 2009-11-13 |
manually curated | Roumanie O, et al. (2001) Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae. FEBS Lett 506(2):149-56 |
SGD |
| CDC6/YJL194W | IDA: Inferred from Direct Assay Assigned on 2007-08-10 |
manually curated | Zwerschke W, et al. (1994) The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation. J Biol Chem 269(37):23351-6 |
SGD |
| DDR48/YMR173W | IDA: Inferred from Direct Assay Assigned on 2004-04-19 |
manually curated | Sheng S and Schuster SM (1993) Purification and characterization of Saccharomyces cerevisiae DNA damage-responsive protein 48 (DDRP 48). J Biol Chem 268(7):4752-8 |
SGD |
| DNM1/YLL001W | IDA: Inferred from Direct Assay Assigned on 2006-07-26 |
manually curated | Ingerman E, et al. (2005) Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol 170(7):1021-7 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR003130, EBI:IPR001401 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| EFT1/YOR133W | IEA: Inferred from Electronic Annotation with EBI:IPR000795 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| EFT2/YDR385W | IEA: Inferred from Electronic Annotation with EBI:IPR000795 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| EST3/YIL009C-A | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2010-12-02 |
manually curated | Shubernetskaya O, et al. (2011) Yeast telomerase protein Est3 is a novel type of GTPase. Biochimie 93(2):202-6 |
SGD |
| FUN12/YAL035W | IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2003-04-23 |
manually curated | Lee JH, et al. (2002) Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation. Proc Natl Acad Sci U S A 99(26):16689-94 |
SGD |
| IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2008-12-09 |
manually curated | Shin BS, et al. (2009) rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit. Mol Cell Biol 29(3):808-21 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR000795 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| FZO1/YBR179C | IDA: Inferred from Direct Assay Assigned on 2011-01-07 |
manually curated | Amiott EA, et al. (2009) A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover. Mol Biol Cell 20(23):5026-35 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR001401, EBI:IPR027091, EBI:IPR027094 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| GCD11/YER025W | IEA: Inferred from Electronic Annotation with EBI:IPR000795 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| GEM1/YAL048C | IDA: Inferred from Direct Assay Assigned on 2005-02-10 |
manually curated | Frederick RL, et al. (2004) Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J Cell Biol 167(1):87-98 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR021181 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| GPA1/YHR005C | IMP: Inferred from Mutant Phenotype Assigned on 2006-07-19 |
manually curated | Kurjan J, et al. (1991) Mutations in the guanine nucleotide-binding domains of a yeast G alpha protein confer a constitutive or uninducible state to the pheromone response pathway. Genes Dev 5(3):475-83 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2006-07-19 |
manually curated | Cismowski MJ, et al. (2001) Biochemical analysis of yeast G(alpha) mutants that enhance adaptation to pheromone. Biochem Biophys Res Commun 284(2):247-54 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR001019, EBI:IPR002975 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| GPA2/YER020W | IMP: Inferred from Mutant Phenotype Assigned on 2007-12-03 |
manually curated | Lorenz MC and Heitman J (1997) Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. EMBO J 16(23):7008-18 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2007-12-03 |
manually curated | Peeters T, et al. (2006) Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A 103(35):13034-9 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR001019, EBI:IPR002975 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| GSP1/YLR293C | IGI: Inferred from Genetic Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-07-24 |
manually curated | Belhumeur P, et al. (1993) GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization. Mol Cell Biol 13(4):2152-61 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR002041 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| GSP2/YOR185C | IGI: Inferred from Genetic Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-07-24 |
manually curated | Belhumeur P, et al. (1993) GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization. Mol Cell Biol 13(4):2152-61 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR002041 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| GUF1/YLR289W | IDA: Inferred from Direct Assay Assigned on 2006-02-03 |
manually curated | Butcher RA, et al. (2006) Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway. Nat Chem Biol 2(2):103-9 |
SGD |
| ISS: Inferred from Sequence or structural Similarity Assigned on 2002-10-07 |
manually curated | Kiser GL and Weinert TA (1995) GUF1, a gene encoding a novel evolutionarily conserved GTPase in budding yeast. Yeast 11(13):1311-6 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR000795 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with HAMAP:MF_03137 Last Updated 2013-03-02 |
computational | Swiss Institute of Bioinformatics (SIB) curators and GOA curators (2006) Electronic Gene Ontology annotations created by transferring manual GO annotations between orthologous microbial proteins |
UniProtKB | |
| HBS1/YKR084C | IDA: Inferred from Direct Assay Assigned on 2010-11-29 |
manually curated | Shoemaker CJ, et al. (2010) Dom34:Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay. Science 330(6002):369-72 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR000795 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IFM1/YOL023W | IDA: Inferred from Direct Assay Assigned on 2003-06-19 |
manually curated | Garofalo C, et al. (2003) Purification and characterization of yeast mitochondrial initiation factor 2. Arch Biochem Biophys 413(2):243-52 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR000795 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| LSG1/YGL099W | ISS: Inferred from Sequence or structural Similarity Assigned on 2003-07-06 |
manually curated | Kallstrom G, et al. (2003) The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively. Mol Cell Biol 23(12):4344-55 |
SGD |
| MEF1/YLR069C | IEA: Inferred from Electronic Annotation with EBI:IPR000795 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| MEF2/YJL102W | IEA: Inferred from Electronic Annotation with EBI:IPR000795 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| MGM1/YOR211C | ISA: Inferred from Sequence Alignment with SGD:DNM1 Assigned on 2010-12-02 |
manually curated | Wong ED, et al. (2000) The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J Cell Biol 151(2):341-52 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR001401 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
