Ontology: Biological Process (GO:0000388)

Definition: Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11).

Synonyms: 3'-splice site cleavage, exon ligation; spliceosomal A1 complex biosynthesis; spliceosomal A1 complex formation; spliceosomal B2 complex biosynthesis; spliceosomal B2 complex formation; U12-type spliceosome conformational change to release U4atac and U11; U2-type spliceosome conformational change to release U4 and U1

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) (4 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	4
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)      4 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
BRR2/YER172C	IMP: Inferred from Mutant Phenotype Assigned on 2007-08-23	manually curated	Raghunathan PL and Guthrie C  (1998) RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2. Curr Biol 8(15):847-55	SGD
PRP38/YGR075C	IMP: Inferred from Mutant Phenotype Assigned on 2007-12-17	manually curated	Xie J, et al.  (1998) Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociation. EMBO J 17(10):2938-46	SGD
SNR6/snR6	IMP: Inferred from Mutant Phenotype Assigned on 2008-04-17	manually curated	McManus CJ, et al.  (2007) A dynamic bulge in the U6 RNA internal stem loop functions in spliceosome assembly and activation. RNA 13(12):2252-2265	SGD
SNU114/YKL173W	IMP: Inferred from Mutant Phenotype Assigned on 2007-08-24	manually curated	Brenner TJ and Guthrie C  (2006) Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain. RNA 12(5):862-71	SGD

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