GO term: translation initiation factor activity 
Ontology: Molecular Function (GO:0003743)
Definition: Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
View Ontology:
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(text)
Definition: Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
translation initiation factor activity (37 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | translation initiation factor activity | 29 |
| High-throughput | none | none |
| Computational (download data) | translation initiation factor activity | 35 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
translation initiation factor activity or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| translation initiation factor activity 37 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| AIM23/YJL131C | ISS: Inferred from Sequence or structural Similarity with EBI:P0A707 Assigned on 2013-04-03 |
manually curated | Atkinson GC, et al. (2012) Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae. Nucleic Acids Res 40(13):6122-34 |
SGD |
| CAF20/YOR276W | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| CDC33/YOL139C | TAS: Traceable Author Statement Assigned on 2001-01-24 |
manually curated | McCarthy JE (1998) Posttranscriptional control of gene expression in yeast. Microbiol Mol Biol Rev 62(4):1492-553 |
SGD |
| ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Brenner C, et al. (1988) CDC33 encodes mRNA cap-binding protein eIF-4E of Saccharomyces cerevisiae. Mol Cell Biol 8(8):3556-9 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR001040, EBI:IPR019770 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| DBP1/YPL119C | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| DED1/YOR204W | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| FUN12/YAL035W | IDA: Inferred from Direct Assay Assigned on 2002-11-13 |
manually curated | Choi SK, et al. (1998) Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast. Science 280(5370):1757-60 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| GCD1/YOR260W | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:GCD2, SGD:GCN3, SGD:SUI2 Assigned on 2006-09-29 |
manually curated | Cigan AM, et al. (1991) Complex formation by positive and negative translational regulators of GCN4. Mol Cell Biol 11(6):3217-28 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2006-09-30 |
manually curated | Ashe MP, et al. (2001) A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols. EMBO J 20(22):6464-74 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| GCD10/YNL062C | IEA: Inferred from Electronic Annotation with EBI:IPR007316 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| GCD11/YER025W | TAS: Traceable Author Statement Assigned on 2001-01-24 |
manually curated | McCarthy JE (1998) Posttranscriptional control of gene expression in yeast. Microbiol Mol Biol Rev 62(4):1492-553 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| GCD2/YGR083C | IGI: Inferred from Genetic Interaction with SGD:GCN3 Assigned on 2006-09-29 |
manually curated | Bushman JL, et al. (1993) Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3. Mol Cell Biol 13(8):4618-31 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2006-09-29 |
manually curated | Foiani M, et al. (1991) GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae. Mol Cell Biol 11(6):3203-16 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| GCD6/YDR211W | IGI: Inferred from Genetic Interaction with SGD:GCN3, IPI: Inferred from Physical Interaction with SGD:GCD1, SGD:GCD2, SGD:GCN3 Assigned on 2006-09-05 |
manually curated | Bushman JL, et al. (1993) Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3. Mol Cell Biol 13(8):4618-31 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| GCD7/YLR291C | IGI: Inferred from Genetic Interaction with SGD:GCN3, IPI: Inferred from Physical Interaction with SGD:GCD1, SGD:GCD2, SGD:GCN3 Assigned on 2006-09-05 |
manually curated | Bushman JL, et al. (1993) Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3. Mol Cell Biol 13(8):4618-31 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| GCN3/YKR026C | IDA: Inferred from Direct Assay Assigned on 2002-08-02 |
manually curated | Bushman JL, et al. (1993) Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3. Mol Cell Biol 13(8):4618-31 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2006-09-28 |
manually curated | Dever TE, et al. (1993) Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. Proc Natl Acad Sci U S A 90(10):4616-20 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| HCR1/YLR192C | IPI: Inferred from Physical Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-10-30 |
manually curated | Valasek L, et al. (2001) Related eIF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for eIF3 integrity and ribosome binding. EMBO J 20(4):891-904 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| HYP2/YEL034W | IDA: Inferred from Direct Assay Assigned on 2011-04-13 |
manually curated | Henderson A and Hershey JW (2011) Eukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 108(16):6415-9 |
SGD |
| IFM1/YOL023W | ISA: Inferred from Sequence Alignment with GenBank/EMBL/DDBJ:ACB04247.1 Assigned on 2008-11-20 |
manually curated | Vambutas A, et al. (1991) Mitochondrial translational-initiation and elongation factors in Saccharomyces cerevisiae. Eur J Biochem 201(3):643-52 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2008-11-20 |
manually curated | Garofalo C, et al. (2005) Characterization of the C2 subdomain of yeast mitochondrial initiation factor 2. Arch Biochem Biophys 439(1):113-20 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR006847, EBI:IPR000178 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| NIP1/YMR309C | IDA: Inferred from Direct Assay Assigned on 2002-01-16 |
manually curated | Phan L, et al. (1998) Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol 18(8):4935-46 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR008905 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| PET122/YER153C | IMP: Inferred from Mutant Phenotype Assigned on 2011-05-24 |
manually curated | Costanzo MC and Fox TD (1988) Specific translational activation by nuclear gene products occurs in the 5' untranslated leader of a yeast mitochondrial mRNA. Proc Natl Acad Sci U S A 85(8):2677-81 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR008732 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| PRT1/YOR361C | IDA: Inferred from Direct Assay Assigned on 2002-01-16 |
manually curated | Phan L, et al. (1998) Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol 18(8):4935-46 |
SGD |
| IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Danaie P, et al. (1995) Isolation of a protein complex containing translation initiation factor Prt1 from Saccharomyces cerevisiae. J Biol Chem 270(9):4288-92 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR011400 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| RLI1/YDR091C | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| RPG1/YBR079C | IDA: Inferred from Direct Assay Assigned on 2002-01-16 |
manually curated | Phan L, et al. (1998) Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol 18(8):4935-46 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SUI1/YNL244C | TAS: Traceable Author Statement Assigned on 2001-01-24 |
manually curated | McCarthy JE (1998) Posttranscriptional control of gene expression in yeast. Microbiol Mol Biol Rev 62(4):1492-553 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR005874, EBI:IPR001950 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| SUI2/YJR007W | TAS: Traceable Author Statement Assigned on 2001-01-24 |
manually curated | McCarthy JE (1998) Posttranscriptional control of gene expression in yeast. Microbiol Mol Biol Rev 62(4):1492-553 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR011488 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SUI3/YPL237W | TAS: Traceable Author Statement Assigned on 2001-01-24 |
manually curated | McCarthy JE (1998) Posttranscriptional control of gene expression in yeast. Microbiol Mol Biol Rev 62(4):1492-553 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR002735, EBI:IPR016189, EBI:IPR016190 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| TIF1/YKR059W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2006-11-06 |
manually curated | Blum S, et al. (1992) ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 89(16):7664-8 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| TIF11/YMR260C | TAS: Traceable Author Statement Assigned on 2001-01-24 |
manually curated | McCarthy JE (1998) Posttranscriptional control of gene expression in yeast. Microbiol Mol Biol Rev 62(4):1492-553 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR001253, EBI:IPR006196, EBI:IPR018104 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| TIF2/YJL138C | ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Linder P and Slonimski PP (1989) An essential yeast protein, encoded by duplicated genes TIF1 and TIF2 and homologous to the mammalian translation initiation factor eIF-4A, can suppress a mitochondrial missense mutation. Proc Natl Acad Sci U S A 86(7):2286-90 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2001-01-18 |
manually curated | Blum S, et al. (1992) ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 89(16):7664-8 |
SGD | |
| TAS: Traceable Author Statement Assigned on 2001-01-24 |
manually curated | McCarthy JE (1998) Posttranscriptional control of gene expression in yeast. Microbiol Mol Biol Rev 62(4):1492-553 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| TIF3/YPR163C | ISS: Inferred from Sequence or structural Similarity with EBI:P23588 Assigned on 2007-12-13 |
manually curated | Coppolecchia R, et al. (1993) A new yeast translation initiation factor suppresses a mutation in the eIF-4A RNA helicase. EMBO J 12(10):4005-11 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| TIF34/YMR146C | IDA: Inferred from Direct Assay Assigned on 2002-01-16 |
manually curated | Phan L, et al. (1998) Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol 18(8):4935-46 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| TIF35/YDR429C | IDA: Inferred from Direct Assay Assigned on 2002-01-16 |
manually curated | Phan L, et al. (1998) Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol 18(8):4935-46 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
