Ontology: Molecular Function (GO:0003723)

Definition: Interacting selectively and non-covalently with an RNA molecule or a portion thereof.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term RNA binding (439 genes) or to its variants containing one or more qualifiers (15 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	contributes_to: RNA binding	15
	RNA binding	204
High-throughput (download data)	RNA binding	1
Computational (download data)	RNA binding	378

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term RNA binding or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

contributes_to: RNA binding      15 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CLP1/YOR250C	IDA: Inferred from Direct Assay Assigned on 2005-02-18	manually curated	Gross S and Moore C  (2001) Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A 98(11):6080-5	SGD
FIP1/YJR093C	IMP: Inferred from Mutant Phenotype Assigned on 2005-02-18	manually curated	Helmling S, et al.  (2001) Fip1 regulates the activity of Poly(A) polymerase through multiple interactions. Mol Cell Biol 21(6):2026-37	SGD
LSM2/YBL026W	IPI: Inferred from Physical Interaction Assigned on 2005-11-29	manually curated	Salgado-Garrido J, et al.  (1999) Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. EMBO J 18(12):3451-62	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-11-29	manually curated	Fernandez CF, et al.  (2004) An Lsm2-Lsm7 complex in Saccharomyces cerevisiae associates with the small nucleolar RNA snR5. Mol Biol Cell 15(6):2842-52	SGD
LSM3/YLR438C-A	IPI: Inferred from Physical Interaction Assigned on 2005-11-29	manually curated	Salgado-Garrido J, et al.  (1999) Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. EMBO J 18(12):3451-62	SGD
LSM5/YER146W	IPI: Inferred from Physical Interaction Assigned on 2005-11-29	manually curated	Salgado-Garrido J, et al.  (1999) Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. EMBO J 18(12):3451-62	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-11-29	manually curated	Fernandez CF, et al.  (2004) An Lsm2-Lsm7 complex in Saccharomyces cerevisiae associates with the small nucleolar RNA snR5. Mol Biol Cell 15(6):2842-52	SGD
LSM6/YDR378C	IPI: Inferred from Physical Interaction Assigned on 2005-11-29	manually curated	Salgado-Garrido J, et al.  (1999) Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. EMBO J 18(12):3451-62	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-11-29	manually curated	Fernandez CF, et al.  (2004) An Lsm2-Lsm7 complex in Saccharomyces cerevisiae associates with the small nucleolar RNA snR5. Mol Biol Cell 15(6):2842-52	SGD
LSM7/YNL147W	IPI: Inferred from Physical Interaction Assigned on 2005-11-29	manually curated	Salgado-Garrido J, et al.  (1999) Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. EMBO J 18(12):3451-62	SGD
LSM8/YJR022W	IPI: Inferred from Physical Interaction Assigned on 2005-11-29	manually curated	Salgado-Garrido J, et al.  (1999) Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. EMBO J 18(12):3451-62	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-11-29	manually curated	Fernandez CF, et al.  (2004) An Lsm2-Lsm7 complex in Saccharomyces cerevisiae associates with the small nucleolar RNA snR5. Mol Biol Cell 15(6):2842-52	SGD
MPE1/YKL059C	IC: Inferred By Curator from mRNA cleavage and polyadenylation specificity factor complex Assigned on 2005-02-22	manually curated	Vo LT, et al.  (2001) Mpe1, a zinc knuckle protein, is an essential component of yeast cleavage and polyadenylation factor required for the cleavage and polyadenylation of mRNA. Mol Cell Biol 21(24):8346-56	SGD
PFS2/YNL317W	IC: Inferred By Curator from mRNA cleavage and polyadenylation specificity factor complex Assigned on 2005-02-18	manually curated	Nedea E, et al.  (2003) Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem 278(35):33000-10	SGD
PTA1/YAL043C	IC: Inferred By Curator from mRNA cleavage and polyadenylation specificity factor complex Assigned on 2005-02-18	manually curated	Zhao J, et al.  (1999) Pta1, a component of yeast CF II, is required for both cleavage and poly(A) addition of mRNA precursor. Mol Cell Biol 19(11):7733-40	SGD
PTI1/YGR156W	IC: Inferred By Curator from mRNA cleavage and polyadenylation specificity factor complex Assigned on 2005-02-18	manually curated	Nedea E, et al.  (2003) Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem 278(35):33000-10	SGD
RNA14/YMR061W	IDA: Inferred from Direct Assay Assigned on 2005-02-18	manually curated	Noble CG, et al.  (2004) Rna14-Rna15 assembly mediates the RNA-binding capability of Saccharomyces cerevisiae cleavage factor IA. Nucleic Acids Res 32(11):3364-75	SGD
SYC1/YOR179C	IC: Inferred By Curator from mRNA cleavage and polyadenylation specificity factor complex Assigned on 2005-02-22	manually curated	Nedea E, et al.  (2003) Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem 278(35):33000-10	SGD
YSH1/YLR277C	IC: Inferred By Curator from mRNA cleavage and polyadenylation specificity factor complex Assigned on 2005-02-18	manually curated	Zhao J, et al.  (1997) Cleavage factor II of Saccharomyces cerevisiae contains homologues to subunits of the mammalian Cleavage/ polyadenylation specificity factor and exhibits sequence-specific, ATP-dependent interaction with precursor RNA. J Biol Chem 272(16):10831-8	SGD

RNA binding      439 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
LSM4/YER112W	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
LSM5/YER146W	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
LSM6/YDR378C	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
LSM7/YNL147W	TAS: Traceable Author Statement Assigned on 2005-02-22	manually curated	Fernandez CF, et al.  (2004) An Lsm2-Lsm7 complex in Saccharomyces cerevisiae associates with the small nucleolar RNA snR5. Mol Biol Cell 15(6):2842-52	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
LSR1	TAS: Traceable Author Statement Assigned on 2002-11-18	manually curated	Xu D and Friesen JD  (2001) Splicing factor slt11p and its involvement in formation of U2/U6 helix II in activation of the yeast spliceosome. Mol Cell Biol 21(4):1011-23	SGD
MAK5/YBR142W	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MER1/YNL210W	IEA: Inferred from Electronic Annotation with EBI:IPR004088, EBI:IPR004087 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MEX67/YPL169C	IDA: Inferred from Direct Assay Assigned on 2003-03-11	manually curated	Hieronymus H and Silver PA  (2003) Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Nat Genet 33(2):155-61	SGD
MIP6/YHR015W	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-08-20	manually curated	Segref A, et al.  (1997) Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J 16(11):3256-71	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MOT2/YER068W	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MPP6/YNR024W	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MPT5/YGL178W	IEA: Inferred from Electronic Annotation with EBI:IPR001313 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MRD1/YPR112C	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MRH4/YGL064C	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MRM1/YOR201C	IEA: Inferred from Electronic Annotation with EBI:IPR001537 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MRN1/YPL184C	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MRPL1/YDR116C	IEA: Inferred from Electronic Annotation with EBI:IPR005879, EBI:IPR023674, EBI:IPR002143 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MRPL15/YLR312W-A	IEA: Inferred from Electronic Annotation with EBI:IPR000999 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MRPL3/YMR024W	IEA: Inferred from Electronic Annotation with EBI:IPR000999, EBI:IPR011907 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MRPL49/YJL096W	IEA: Inferred from Electronic Annotation with EBI:IPR001787 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MRPL6/YHR147C	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MRPS17/YMR188C	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MRPS28/YDR337W	ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	manually curated	Graack HR and Wittmann-Liebold B  (1998) Mitochondrial ribosomal proteins (MRPs) of yeast. Biochem J 329 ( Pt 3)():433-48	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MRPS5/YBR251W	IEA: Inferred from Electronic Annotation with EBI:IPR013810 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MRS1/YIR021W	IDA: Inferred from Direct Assay Assigned on 2003-08-21	manually curated	Bassi GS, et al.  (2002) Recruitment of intron-encoded and co-opted proteins in splicing of the bI3 group I intron RNA. Proc Natl Acad Sci U S A 99(1):128-33	SGD
MSE1/YOL033W	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MSL1/YIR009W	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MSL5/YLR116W	IEA: Inferred from Electronic Annotation with EBI:IPR004088, EBI:IPR004087 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MSS116/YDR194C	IDA: Inferred from Direct Assay Assigned on 2006-11-08	manually curated	Halls C, et al.  (2007) Involvement of DEAD-box proteins in group I and group II intron splicing. Biochemical characterization of Mss116p, ATP hydrolysis-dependent and -independent mechanisms, and general RNA chaperone activity. J Mol Biol 365(3):835-55	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0694 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
MSY1/YPL097W	IEA: Inferred from Electronic Annotation with EBI:IPR002942 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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