Ontology: Molecular Function (GO:0003700)

Definition: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

Synonyms: transcription factor activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term sequence-specific DNA binding transcription factor activity (76 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	sequence-specific DNA binding transcription factor activity	32
High-throughput	none	none
Computational (download data)	sequence-specific DNA binding transcription factor activity	59

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term sequence-specific DNA binding transcription factor activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

sequence-specific DNA binding transcription factor activity      76 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
SRD1/YCR018C	IEA: Inferred from Electronic Annotation with EBI:IPR000679 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
STB5/YHR178W	IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-06-17	manually curated	Akache B and Turcotte B  (2002) New regulators of drug sensitivity in the family of yeast zinc cluster proteins. J Biol Chem 277(24):21254-60	SGD
STE12/YHR084W	IPI: Inferred from Physical Interaction Assigned on 2001-01-18	manually curated	Errede B and Ammerer G  (1989) STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes. Genes Dev 3(9):1349-61	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR003120 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SWI4/YER111C	IEA: Inferred from Electronic Annotation with EBI:IPR003163 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
TEC1/YBR083W	IEA: Inferred from Electronic Annotation with EBI:IPR000818 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
TOS8/YGL096W	IEA: Inferred from Electronic Annotation with EBI:IPR001356 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
TYE7/YOR344C	IDA: Inferred from Direct Assay Assigned on 2005-01-17	manually curated	Sato T, et al.  (1999) The E-box DNA binding protein Sgc1p suppresses the gcr2 mutation, which is involved in transcriptional activation of glycolytic genes in Saccharomyces cerevisiae. FEBS Lett 463(3):307-11	SGD
WAR1/YML076C	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2003-05-09	manually curated	Kren A, et al.  (2003) War1p, a novel transcription factor controlling weak acid stress response in yeast. Mol Cell Biol 23(5):1775-85	SGD
XBP1/YIL101C	IDA: Inferred from Direct Assay Assigned on 2002-02-21	manually curated	Mai B and Breeden L  (1997) Xbp1, a stress-induced transcriptional repressor of the Saccharomyces cerevisiae Swi4/Mbp1 family. Mol Cell Biol 17(11):6491-501	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR003163 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
YAP1/YML007W	IDA: Inferred from Direct Assay Assigned on 2005-01-17	manually curated	Nguyen DT, et al.  (2001) Multiple Yap1p-binding sites mediate induction of the yeast major facilitator FLR1 gene in response to drugs, oxidants, and alkylating agents. J Biol Chem 276(2):1138-45	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
YAP3/YHL009C	IDA: Inferred from Direct Assay Assigned on 2002-10-21	manually curated	Fernandes L, et al.  (1997) Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol 17(12):6982-93	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
YAP5/YIR018W	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
YAP6/YDR259C	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
YAP7/YOL028C	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
YHP1/YDR451C	IEA: Inferred from Electronic Annotation with EBI:IPR001356 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
YOX1/YML027W	IEA: Inferred from Electronic Annotation with EBI:IPR001356 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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