Ontology: Molecular Function (GO:0003700)

Definition: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

Synonyms: transcription factor activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term sequence-specific DNA binding transcription factor activity (76 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	sequence-specific DNA binding transcription factor activity	32
High-throughput	none	none
Computational (download data)	sequence-specific DNA binding transcription factor activity	59

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term sequence-specific DNA binding transcription factor activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

sequence-specific DNA binding transcription factor activity      76 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
HMRA1/YCR097W	IEA: Inferred from Electronic Annotation with EBI:IPR001356 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HMRA2/YCR096C	IEA: Inferred from Electronic Annotation with EBI:IPR001356 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HMS1/YOR032C	ISS: Inferred from Sequence or structural Similarity Assigned on 2005-11-08	manually curated	Robinson KA and Lopes JM  (2000) SURVEY AND SUMMARY: Saccharomyces cerevisiae basic helix-loop-helix proteins regulate diverse biological processes. Nucleic Acids Res 28(7):1499-505	SGD
HMS2/YJR147W	IEA: Inferred from Electronic Annotation with EBI:IPR000232 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HSF1/YGL073W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Wiederrecht G, et al.  (1988) Isolation of the gene encoding the S. cerevisiae heat shock transcription factor. Cell 54(6):841-53	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000232 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
KAR4/YCL055W	IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction with SGD:KAR3, IMP: Inferred from Mutant Phenotype Assigned on 2006-11-27	manually curated	Lahav R, et al.  (2007) Role of transcription factor Kar4 in regulating downstream events in the Saccharomyces cerevisiae pheromone response pathway. Mol Cell Biol 27(3):818-29	SGD
MAC1/YMR021C	IEA: Inferred from Electronic Annotation with EBI:IPR001083 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MAL13/YGR288W	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-06-05	manually curated	Hu Z, et al.  (1999) Functional domain analysis of the Saccharomyces MAL-activator. Curr Genet 36(1-2):1-12	SGD
MAL23	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-06-05	manually curated	Hu Z, et al.  (1999) Functional domain analysis of the Saccharomyces MAL-activator. Curr Genet 36(1-2):1-12	SGD
MAL33/YBR297W	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-06-05	manually curated	Hu Z, et al.  (1999) Functional domain analysis of the Saccharomyces MAL-activator. Curr Genet 36(1-2):1-12	SGD
MAL43	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-06-05	manually curated	Hu Z, et al.  (1999) Functional domain analysis of the Saccharomyces MAL-activator. Curr Genet 36(1-2):1-12	SGD
MAL63	TAS: Traceable Author Statement Assigned on 2002-06-05	manually curated	Hu Z, et al.  (1999) Functional domain analysis of the Saccharomyces MAL-activator. Curr Genet 36(1-2):1-12	SGD
MATALPHA2/YCR039C	IEA: Inferred from Electronic Annotation with EBI:IPR001356 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MBP1/YDL056W	IEA: Inferred from Electronic Annotation with EBI:IPR003163 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MET28/YIR017C	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MET4/YNL103W	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MGA1/YGR249W	IMP: Inferred from Mutant Phenotype Assigned on 2006-10-26	manually curated	Borneman AR, et al.  (2006) Target hub proteins serve as master regulators of development in yeast. Genes Dev 20(4):435-48	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000232 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
NDT80/YHR124W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-03-07	manually curated	Chu S and Herskowitz I  (1998) Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80. Mol Cell 1(5):685-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR008967 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
OAF1/YAL051W	IEA: Inferred from Electronic Annotation with EBI:IPR002409 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PHD1/YKL043W	IMP: Inferred from Mutant Phenotype Assigned on 2006-10-26	manually curated	Borneman AR, et al.  (2006) Target hub proteins serve as master regulators of development in yeast. Genes Dev 20(4):435-48	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR003163 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PHO2/YDL106C	IEA: Inferred from Electronic Annotation with EBI:IPR001356 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PHO4/YFR034C	TAS: Traceable Author Statement Assigned on 2001-11-01	manually curated	Lenburg ME and O'Shea EK  (1996) Signaling phosphate starvation. Trends Biochem Sci 21(10):383-7	SGD
PIP2/YOR363C	IEA: Inferred from Electronic Annotation with EBI:IPR002409 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RDR1/YOR380W	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-06-17	manually curated	Hellauer K, et al.  (2002) Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter. J Biol Chem 277(20):17671-6	SGD
RSF2/YJR127C	ISS: Inferred from Sequence or structural Similarity with SGD:ADR1 Assigned on 2003-04-28	manually curated	Grabowska D and Chelstowska A  (2003) The ALD6 gene product is indispensable for providing NADPH in yeast cells lacking glucose-6-phosphate dehydrogenase activity. J Biol Chem 278(16):13984-8	SGD
SFL1/YOR140W	IEA: Inferred from Electronic Annotation with EBI:IPR000232 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SKN7/YHR206W	IDA: Inferred from Direct Assay Assigned on 2005-01-17	manually curated	Li S, et al.  (2002) The eukaryotic two-component histidine kinase Sln1p regulates OCH1 via the transcription factor, Skn7p. Mol Biol Cell 13(2):412-24	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-07-26	manually curated	Morgan BA, et al.  (1997) The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae. EMBO J 16(5):1035-44	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR014402, EBI:IPR000232 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SKO1/YNL167C	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SMP1/YBR182C	IC: Inferred By Curator from sequence-specific DNA binding Assigned on 2011-09-06	manually curated	Dodou E and Treisman R  (1997) The Saccharomyces cerevisiae MADS-box transcription factor Rlm1 is a target for the Mpk1 mitogen-activated protein kinase pathway. Mol Cell Biol 17(4):1848-59	SGD
	IC: Inferred By Curator from positive regulation of transcription from RNA polymerase II promoter Assigned on 2011-09-06	manually curated	de Nadal E, et al.  (2003) Targeting the MEF2-like transcription factor Smp1 by the stress-activated Hog1 mitogen-activated protein kinase. Mol Cell Biol 23(1):229-37	SGD
SOK2/YMR016C	ISS: Inferred from Sequence or structural Similarity Assigned on 2001-06-26	manually curated	Ward MP, et al.  (1995) SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription. Mol Cell Biol 15(12):6854-63	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR003163 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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