Ontology: Molecular Function (GO:0003700)

Definition: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

Synonyms: transcription factor activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term sequence-specific DNA binding transcription factor activity (76 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	sequence-specific DNA binding transcription factor activity	32
High-throughput	none	none
Computational (download data)	sequence-specific DNA binding transcription factor activity	59

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term sequence-specific DNA binding transcription factor activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

sequence-specific DNA binding transcription factor activity      76 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ACA1/YER045C	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ARR1/YPR199C	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ASH1/YKL185W	IEA: Inferred from Electronic Annotation with EBI:IPR000679 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CAD1/YDR423C	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CHA4/YLR098C	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2003-04-02	manually curated	Holmberg S and Schjerling P  (1996) Cha4p of Saccharomyces cerevisiae activates transcription via serine/threonine response elements. Genetics 144(2):467-78	SGD
CIN5/YOR028C	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CST6/YIL036W	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CUP2/YGL166W	IEA: Inferred from Electronic Annotation with EBI:IPR001083 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CUP9/YPL177C	IEA: Inferred from Electronic Annotation with EBI:IPR001356 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
DAL80/YKR034W	IEA: Inferred from Electronic Annotation with EBI:IPR000679 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
DAL82/YNL314W	IC: Inferred By Curator from sequence-specific DNA binding, nitrogen catabolite activation of transcription from RNA polymerase II promoter Assigned on 2011-12-21	manually curated	GO Annotation Working Group  (2011) Manual annotations that require more than one source of functional data to support the assignment of the associated GO term.	SGD
ECM23/YPL021W	IEA: Inferred from Electronic Annotation with EBI:IPR000679 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
FAP1/YNL023C	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-05-29	manually curated	Kunz J, et al.  (2000) FAP1, a homologue of human transcription factor NF-X1, competes with rapamycin for binding to FKBP12 in yeast. Mol Microbiol 37(6):1480-93	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000967 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
FHL1/YPR104C	IEA: Inferred from Electronic Annotation with EBI:IPR018122, EBI:IPR001766 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
FKH1/YIL131C	IEA: Inferred from Electronic Annotation with EBI:IPR018122, EBI:IPR001766 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
FKH2/YNL068C	IEA: Inferred from Electronic Annotation with EBI:IPR018122, EBI:IPR001766 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GAT1/YFL021W	IEA: Inferred from Electronic Annotation with EBI:IPR000679 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GAT2/YMR136W	IEA: Inferred from Electronic Annotation with EBI:IPR000679 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GAT3/YLR013W	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-02-15	manually curated	Cox KH, et al.  (1999) Genome-wide transcriptional analysis in S. cerevisiae by mini-array membrane hybridization. Yeast 15(8):703-13	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000679 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GAT4/YIR013C	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-02-15	manually curated	Cox KH, et al.  (1999) Genome-wide transcriptional analysis in S. cerevisiae by mini-array membrane hybridization. Yeast 15(8):703-13	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000679 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GCN4/YEL009C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2011-11-14	manually curated	Qiu H, et al.  (2006) The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II. Mol Cell Biol 26(8):3135-48	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GLN3/YER040W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2011-06-23	manually curated	Cunningham TS, et al.  (1996) G1n3p is capable of binding to UAS(NTR) elements and activating transcription in Saccharomyces cerevisiae. J Bacteriol 178(12):3470-9	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR000679 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GSM1/YJL103C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2012-10-24	manually curated	Ho SW, et al.  (2006) Linking DNA-binding proteins to their recognition sequences by using protein microarrays. Proc Natl Acad Sci U S A 103(26):9940-5	SGD
GZF3/YJL110C	IEA: Inferred from Electronic Annotation with EBI:IPR000679 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HAA1/YPR008W	IEA: Inferred from Electronic Annotation with EBI:IPR001083 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HAC1/YFL031W	IEA: Inferred from Electronic Annotation with EBI:IPR004827 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HAP2/YGL237C	IEA: Inferred from Electronic Annotation with EBI:IPR001289 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HAP5/YOR358W	IEA: Inferred from Electronic Annotation with EBI:IPR027170 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HCM1/YCR065W	IEA: Inferred from Electronic Annotation with EBI:IPR018122, EBI:IPR001766 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HMLALPHA2/YCL067C	IEA: Inferred from Electronic Annotation with EBI:IPR001356 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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