GO term: chromatin binding 
Ontology: Molecular Function (GO:0003682)
Definition: Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
Synonyms: microtubule/chromatin interaction; lamin/chromatin binding; nuclear membrane vesicle binding to chromatin
View Ontology:
(graph) | 
(text)
Definition: Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
Synonyms: microtubule/chromatin interaction; lamin/chromatin binding; nuclear membrane vesicle binding to chromatin
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
chromatin binding (75 genes)
or to its variants containing one or more
qualifiers (3 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | chromatin binding | 57 |
| contributes_to: chromatin binding | 3 | |
| High-throughput | none | none |
| Computational (download data) | chromatin binding | 19 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
chromatin binding or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| chromatin binding 75 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ADA2/YDR448W | IDA: Inferred from Direct Assay Assigned on 2009-11-13 |
manually curated | Jacobson S and Pillus L (2009) The SAGA subunit Ada2 functions in transcriptional silencing. Mol Cell Biol 29(22):6033-45 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR001005 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| ARP4/YJL081C | IDA: Inferred from Direct Assay Assigned on 2001-01-18 |
manually curated | Harata M, et al. (1999) The nuclear actin-related protein of Saccharomyces cerevisiae, Act3p/Arp4, interacts with core histones. Mol Biol Cell 10(8):2595-605 |
SGD |
| BAS1/YKR099W | IEA: Inferred from Electronic Annotation with EBI:IPR001005 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| BDF1/YLR399C | IDA: Inferred from Direct Assay Assigned on 2012-01-19 |
manually curated | Ladurner AG, et al. (2003) Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries. Mol Cell 11(2):365-76 |
SGD |
| BDP1/YNL039W | IEA: Inferred from Electronic Annotation with EBI:IPR001005 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| CDC45/YLR103C | IDA: Inferred from Direct Assay Assigned on 2007-08-09 |
manually curated | Zou L and Stillman B (1998) Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin. Science 280(5363):593-6 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2007-08-15 |
manually curated | Ricke RM and Bielinsky AK (2004) Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha. Mol Cell 16(2):173-85 |
SGD | |
| CDC6/YJL194W | IDA: Inferred from Direct Assay Assigned on 2007-08-09 |
manually curated | Tanaka T, et al. (1997) Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell 90(4):649-60 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2007-08-09 |
manually curated | Donovan S, et al. (1997) Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci U S A 94(11):5611-6 |
SGD | |
| IMP: Inferred from Mutant Phenotype Assigned on 2007-08-10 |
manually curated | Wang B, et al. (1999) The essential role of Saccharomyces cerevisiae CDC6 nucleotide-binding site in cell growth, DNA synthesis, and Orc1 association. J Biol Chem 274(12):8291-8 |
SGD | |
| CDC73/YLR418C | IDA: Inferred from Direct Assay Assigned on 2011-10-21 |
manually curated | Pokholok DK, et al. (2002) Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. Mol Cell 9(4):799-809 |
SGD |
| CEF1/YMR213W | IEA: Inferred from Electronic Annotation with EBI:IPR001005 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| CLF1/YLR117C | IDA: Inferred from Direct Assay Assigned on 2010-04-21 |
manually curated | Zhu W, et al. (2002) Evidence that the pre-mRNA splicing factor Clf1p plays a role in DNA replication in Saccharomyces cerevisiae. Genetics 160(4):1319-33 |
SGD |
| CTF4/YPR135W | IDA: Inferred from Direct Assay Assigned on 2010-04-29 |
manually curated | Wang J, et al. (2010) Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast. Biochem Biophys Res Commun 395(3):336-41 |
SGD |
| DOT6/YER088C | IEA: Inferred from Electronic Annotation with EBI:IPR001005 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| EAF1/YDR359C | IEA: Inferred from Electronic Annotation with EBI:IPR001005 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| ECO1/YFR027W | IDA: Inferred from Direct Assay Assigned on 2004-07-27 |
manually curated | Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 |
UniProtKB |
| ELG1/YOR144C | IDA: Inferred from Direct Assay Assigned on 2011-03-30 |
manually curated | Davidson MB and Brown GW (2008) The N- and C-termini of Elg1 contribute to the maintenance of genome stability. DNA Repair (Amst) 7(8):1221-32 |
SGD |
| FUN30/YAL019W | IDA: Inferred from Direct Assay Assigned on 2010-11-29 |
manually curated | Awad S, et al. (2010) The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J Biol Chem 285(13):9477-84 |
SGD |
| GCN4/YEL009C | IDA: Inferred from Direct Assay Assigned on 2011-11-14 |
manually curated | Zhang F, et al. (2008) Disrupting vesicular trafficking at the endosome attenuates transcriptional activation by Gcn4. Mol Cell Biol 28(22):6796-818 |
SGD |
| HDA1/YNL021W | IDA: Inferred from Direct Assay Assigned on 2009-05-15 |
manually curated | Kanta H, et al. (2006) Suppressor analysis of a histone defect identifies a new function for the hda1 complex in chromosome segregation. Genetics 173(1):435-50 |
SGD |
| HDA2/YDR295C | IDA: Inferred from Direct Assay Assigned on 2009-05-15 |
manually curated | Kanta H, et al. (2006) Suppressor analysis of a histone defect identifies a new function for the hda1 complex in chromosome segregation. Genetics 173(1):435-50 |
SGD |
| HDA3/YPR179C | IDA: Inferred from Direct Assay Assigned on 2009-05-15 |
manually curated | Kanta H, et al. (2006) Suppressor analysis of a histone defect identifies a new function for the hda1 complex in chromosome segregation. Genetics 173(1):435-50 |
SGD |
| HIR1/YBL008W | IEA: Inferred from Electronic Annotation with EBI:IPR019015 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| HTZ1/YOL012C | IGI: Inferred from Genetic Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Jackson JD and Gorovsky MA (2000) Histone H2A.Z has a conserved function that is distinct from that of the major H2A sequence variants. Nucleic Acids Res 28(19):3811-6 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2001-01-18 |
manually curated | Santisteban MS, et al. (2000) Histone H2A.Z regulats transcription and is partially redundant with nucleosome remodeling complexes. Cell 103(3):411-22 |
SGD | |
| IMD2/YHR216W | IDA: Inferred from Direct Assay Assigned on 2010-02-05 |
manually curated | Park JH and Ahn SH (2010) IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II. Biochem Biophys Res Commun 392(4):588-592 |
SGD |
| IPI1/YHR085W | IDA: Inferred from Direct Assay Assigned on 2013-02-12 |
manually curated | Huo L, et al. (2012) The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis. Cell Cycle 11(7):1325-39 |
SGD |
| IPI3/YNL182C | IDA: Inferred from Direct Assay Assigned on 2013-02-12 |
manually curated | Huo L, et al. (2012) The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis. Cell Cycle 11(7):1325-39 |
SGD |
| IRR1/YIL026C | IDA: Inferred from Direct Assay Assigned on 2009-04-03 |
manually curated | Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 |
SGD |
| ISW1/YBR245C | IEA: Inferred from Electronic Annotation with EBI:IPR001005 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| ISW2/YOR304W | IEA: Inferred from Electronic Annotation with EBI:IPR001005 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| KTI12/YKL110C | IDA: Inferred from Direct Assay Assigned on 2006-09-12 |
manually curated | Petrakis TG, et al. (2005) Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein. J Biol Chem 280(20):19454-60 |
SGD |
| LIF1/YGL090W | IDA: Inferred from Direct Assay Assigned on 2007-04-25 |
manually curated | Teo SH and Jackson SP (2000) Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks. Curr Biol 10(3):165-8 |
SGD |
| contributes_to: chromatin binding 3 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| HTL1/YCR020W-B | IC: Inferred By Curator from RSC complex Assigned on 2006-01-30 |
manually curated | Romeo MJ, et al. (2002) HTL1 encodes a novel factor that interacts with the RSC chromatin remodeling complex in Saccharomyces cerevisiae. Mol Cell Biol 22(23):8165-74 |
SGD |
| POB3/YML069W | IDA: Inferred from Direct Assay Assigned on 2010-03-03 |
manually curated | Wittmeyer J, et al. (1999) Spt16 and Pob3 of Saccharomyces cerevisiae form an essential, abundant heterodimer that is nuclear, chromatin-associated, and copurifies with DNA polymerase alpha. Biochemistry 38(28):8961-71 |
SGD |
| SPT16/YGL207W | IDA: Inferred from Direct Assay Assigned on 2010-03-03 |
manually curated | Wittmeyer J, et al. (1999) Spt16 and Pob3 of Saccharomyces cerevisiae form an essential, abundant heterodimer that is nuclear, chromatin-associated, and copurifies with DNA polymerase alpha. Biochemistry 38(28):8961-71 |
SGD |
