Ontology: Molecular Function (GO:0003677)

Definition: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Synonyms: microtubule/chromatin interaction; plasmid binding

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term DNA binding (496 genes) or to its variants containing one or more qualifiers (8 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	contributes_to: DNA binding	8
	DNA binding	44
High-throughput (download data)	DNA binding	10
Computational (download data)	DNA binding	478

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term DNA binding or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

contributes_to: DNA binding      8 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
HIR1/YBL008W	IDA: Inferred from Direct Assay Assigned on 2008-02-12	manually curated	Prochasson P, et al.  (2005) The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev 19(21):2534-9	SGD
HIR2/YOR038C	IDA: Inferred from Direct Assay Assigned on 2008-02-12	manually curated	Prochasson P, et al.  (2005) The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev 19(21):2534-9	SGD
HIR3/YJR140C	IDA: Inferred from Direct Assay Assigned on 2008-02-12	manually curated	Prochasson P, et al.  (2005) The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev 19(21):2534-9	SGD
HPC2/YBR215W	IDA: Inferred from Direct Assay Assigned on 2008-02-12	manually curated	Prochasson P, et al.  (2005) The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev 19(21):2534-9	SGD
IOC2/YLR095C	IDA: Inferred from Direct Assay Assigned on 2009-03-20	manually curated	Vary JC Jr, et al.  (2003) Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol 23(1):80-91	SGD
IOC3/YFR013W	IDA: Inferred from Direct Assay Assigned on 2009-03-20	manually curated	Vary JC Jr, et al.  (2003) Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol 23(1):80-91	SGD
IOC4/YMR044W	IDA: Inferred from Direct Assay Assigned on 2009-03-20	manually curated	Vary JC Jr, et al.  (2003) Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol 23(1):80-91	SGD
ISW1/YBR245C	IDA: Inferred from Direct Assay Assigned on 2009-03-20	manually curated	Vary JC Jr, et al.  (2003) Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol 23(1):80-91	SGD

DNA binding      496 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ABF1/YKL112W	IEA: Inferred from Electronic Annotation with EBI:IPR006774 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ABF2/YMR072W	IDA: Inferred from Direct Assay Assigned on 2002-09-17	manually curated	Zelenaya-Troitskaya O, et al.  (1998) Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae. Genetics 148(4):1763-76	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ACA1/YER045C	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ACE2/YLR131C	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ADA2/YDR448W	IEA: Inferred from Electronic Annotation with EBI:IPR009057 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ADR1/YDR216W	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
AI3/Q0060	IEA: Inferred from Electronic Annotation with EBI:IPR001982 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
AI4/Q0065	IEA: Inferred from Electronic Annotation with EBI:IPR001982 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
AI5_BETA/Q0075	IEA: Inferred from Electronic Annotation with EBI:IPR001982 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
APN1/YKL114C	IEA: Inferred from Electronic Annotation with EBI:IPR001719, EBI:IPR018246 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
APN2/YBL019W	IEA: Inferred from Electronic Annotation with EBI:IPR020848 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ARC1/YGL105W	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ARG80/YMR042W	IEA: Inferred from Electronic Annotation with EBI:IPR002100 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ARG81/YML099C	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ARO80/YDR421W	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ARR1/YPR199C	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ASG1/YIL130W	IEA: Inferred from Electronic Annotation with EBI:IPR007219 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ASH1/YKL185W	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
AZF1/YOR113W	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
BAS1/YKR099W	IEA: Inferred from Electronic Annotation with EBI:IPR009057 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
BDP1/YNL039W	IEA: Inferred from Electronic Annotation with EBI:IPR009057 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BI3/Q0115	IEA: Inferred from Electronic Annotation with EBI:IPR001982 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BI4/Q0120	IEA: Inferred from Electronic Annotation with EBI:IPR001982 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BRF1/YGR246C	IDA: Inferred from Direct Assay Assigned on 2009-08-31	manually curated	Kassavetis GA, et al.  (1997) Domains of the Brf component of RNA polymerase III transcription factor IIIB (TFIIIB): functions in assembly of TFIIIB-DNA complexes and recruitment of RNA polymerase to the promoter. Mol Cell Biol 17(9):5299-306	SGD
CAD1/YDR423C	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CAT8/YMR280C	IEA: Inferred from Electronic Annotation with EBI:IPR007219 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CBF1/YJR060W	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CBF2/YGR140W	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CBF5/YLR175W	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CDC13/YDL220C	IEA: Inferred from Electronic Annotation with EBI:IPR011564 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0238 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

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