Ontology: Biological Process (GO:0035376)

Definition: The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

Synonyms: sterol influx; sterol uptake

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term sterol import (5 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	sterol import	5
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term sterol import or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

sterol import      5 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ARV1/YLR242C	IGI: Inferred from Genetic Interaction with SGD:UPC2, IMP: Inferred from Mutant Phenotype Assigned on 2012-03-08	manually curated	Tinkelenberg AH, et al.  (2000) Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1. J Biol Chem 275(52):40667-70	SGD
AUS1/YOR011W	IGI: Inferred from Genetic Interaction with SGD:PDR11 Assigned on 2011-05-16	manually curated	Kohut P, et al.  (2011) The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: Dehydroergosterol fluorescence study. Biochem Biophys Res Commun 404(1):233-8	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-05-16	manually curated	Marek M, et al.  (2011) The yeast plasma membrane ATP binding cassette (ABC) transporter Aus1: purification, characterization, and the effect of lipids on its activity. J Biol Chem 286(24):21835-43	SGD
CLA4/YNL298W	IMP: Inferred from Mutant Phenotype Assigned on 2010-03-30	manually curated	Lin M, et al.  (2009) The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway. Mol Biol Cell 20(22):4826-37	SGD
SKM1/YOL113W	IMP: Inferred from Mutant Phenotype Assigned on 2010-03-30	manually curated	Lin M, et al.  (2009) The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway. Mol Biol Cell 20(22):4826-37	SGD
STE20/YHL007C	IMP: Inferred from Mutant Phenotype Assigned on 2010-03-30	manually curated	Lin M, et al.  (2009) The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway. Mol Biol Cell 20(22):4826-37	SGD

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