GO term: NuA4 histone acetyltransferase complex 
Ontology: Cellular Component (GO:0035267)
Definition: A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
Synonyms: TIP60 histone acetylase complex; TIP60 histone acetyltransferase complex
View Ontology:
(graph) | 
(text)
Definition: A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
Synonyms: TIP60 histone acetylase complex; TIP60 histone acetyltransferase complex
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
NuA4 histone acetyltransferase complex (13 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | NuA4 histone acetyltransferase complex | 13 |
| High-throughput | none | none |
| Computational (download data) | NuA4 histone acetyltransferase complex | 2 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
NuA4 histone acetyltransferase complex or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| NuA4 histone acetyltransferase complex 13 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ACT1/YFL039C | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Zhang H, et al. (2004) The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24(21):9424-36 |
SGD |
| ARP4/YJL081C | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Galarneau L, et al. (2000) Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription. Mol Cell 5(6):927-37 |
SGD |
| EAF1/YDR359C | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Krogan NJ, et al. (2004) Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A 101(37):13513-8 |
SGD |
| IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Zhang H, et al. (2004) The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24(21):9424-36 |
SGD | |
| EAF3/YPR023C | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Zhang H, et al. (2004) The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24(21):9424-36 |
SGD |
| EAF5/YEL018W | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Zhang H, et al. (2004) The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24(21):9424-36 |
SGD |
| EAF6/YJR082C | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Zhang H, et al. (2004) The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24(21):9424-36 |
SGD |
| EAF7/YNL136W | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Krogan NJ, et al. (2004) Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A 101(37):13513-8 |
SGD |
| EPL1/YFL024C | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Zhang H, et al. (2004) The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24(21):9424-36 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR024943 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| ESA1/YOR244W | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Allard S, et al. (1999) NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J 18(18):5108-19 |
SGD |
| IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Zhang H, et al. (2004) The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24(21):9424-36 |
SGD | |
| SWC4/YGR002C | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Krogan NJ, et al. (2004) Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A 101(37):13513-8 |
SGD |
| IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Zhang H, et al. (2004) The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24(21):9424-36 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR027109 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| TRA1/YHR099W | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Allard S, et al. (1999) NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J 18(18):5108-19 |
SGD |
| YAF9/YNL107W | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Zhang H, et al. (2004) The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24(21):9424-36 |
SGD |
| YNG2/YHR090C | IPI: Inferred from Physical Interaction Assigned on 2007-01-03 |
manually curated | Zhang H, et al. (2004) The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24(21):9424-36 |
SGD |
