GO term: cellular response to oxidative stress 
Ontology: Biological Process (GO:0034599)
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
Synonyms: adaptive response to oxidative stress
View Ontology:
(graph) | 
(text)
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
Synonyms: adaptive response to oxidative stress
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
cellular response to oxidative stress (69 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | cellular response to oxidative stress | 68 |
| High-throughput | none | none |
| Computational (download data) | cellular response to oxidative stress | 2 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
cellular response to oxidative stress or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| cellular response to oxidative stress 69 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ACT1/YFL039C | IGI: Inferred from Genetic Interaction with SGD:OYE2 Assigned on 2007-02-12 |
manually curated | Farah ME and Amberg DC (2007) Conserved actin cysteine residues are oxidative stress sensors that can regulate cell death in yeast. Mol Biol Cell 18(4):1359-65 |
SGD |
| AFG1/YEL052W | IMP: Inferred from Mutant Phenotype Assigned on 2007-06-08 |
manually curated | Khalimonchuk O, et al. (2007) Evidence for a pro-oxidant intermediate in the assembly of cytochrome oxidase. J Biol Chem 282(24):17442-9 |
SGD |
| AFT2/YPL202C | IGI: Inferred from Genetic Interaction with SGD:AFT1 Assigned on 2012-01-05 |
manually curated | Blaiseau PL, et al. (2001) Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem 276(36):34221-6 |
SGD |
| AHP1/YLR109W | IGI: Inferred from Genetic Interaction with SGD:PRX1, SGD:TSA1, SGD:TSA2, SGD:DOT5 Assigned on 2006-08-11 |
manually curated | Wong CM, et al. (2004) Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. J Biol Chem 279(22):23207-13 |
SGD |
| ALO1/YML086C | IMP: Inferred from Mutant Phenotype Assigned on 2002-08-01 |
manually curated | Huh WK, et al. (1998) D-Erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae. Mol Microbiol 30(4):895-903 |
SGD |
| ASK10/YGR097W | IGI: Inferred from Genetic Interaction with SGD:SSN8, IMP: Inferred from Mutant Phenotype Assigned on 2004-01-20 |
manually curated | Cohen TJ, et al. (2003) Ask10p mediates the oxidative stress-induced destruction of the Saccharomyces cerevisiae C-type cyclin Ume3p/Srb11p. Eukaryot Cell 2(5):962-70 |
SGD |
| ATX1/YNL259C | IMP: Inferred from Mutant Phenotype Assigned on 2002-09-19 |
manually curated | Lin SJ and Culotta VC (1995) The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity. Proc Natl Acad Sci U S A 92(9):3784-8 |
SGD |
| CCP1/YKR066C | IMP: Inferred from Mutant Phenotype Assigned on 2002-09-27 |
manually curated | Charizanis C, et al. (1999) The mitochondrial cytochrome c peroxidase Ccp1 of Saccharomyces cerevisiae is involved in conveying an oxidative stress signal to the transcription factor Pos9 (Skn7). Mol Gen Genet 262(3):437-47 |
SGD |
| DOT5/YIL010W | IGI: Inferred from Genetic Interaction with SGD:PRX1, SGD:TSA1, SGD:TSA2, SGD:AHP1 Assigned on 2006-08-11 |
manually curated | Wong CM, et al. (2004) Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. J Biol Chem 279(22):23207-13 |
SGD |
| EOS1/YNL080C | IMP: Inferred from Mutant Phenotype Assigned on 2007-01-04 |
manually curated | Nakamura T, et al. (2007) EOS1, whose deletion confers sensitivity to oxidative stress, is involved in N-glycosylation in Saccharomyces cerevisiae. Biochem Biophys Res Commun 353(2):293-8 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR021100 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| ERV1/YGR029W | IMP: Inferred from Mutant Phenotype Assigned on 2006-10-05 |
manually curated | Mesecke N, et al. (2005) A disulfide relay system in the intermembrane space of mitochondria that mediates protein import. Cell 121(7):1059-69 |
SGD |
| FAP7/YDL166C | IMP: Inferred from Mutant Phenotype Assigned on 2001-06-26 |
manually curated | Juhnke H, et al. (2000) The essential protein fap7 is involved in the oxidative stress response of Saccharomyces cerevisiae. Mol Microbiol 35(4):936-48 |
SGD |
| FRM2/YCL026C-A | IGI: Inferred from Genetic Interaction with SGD:HBN1, IMP: Inferred from Mutant Phenotype Assigned on 2012-07-05 |
manually curated | de Oliveira IM, et al. (2010) The role of two putative nitroreductases, Frm2p and Hbn1p, in the oxidative stress response in Saccharomyces cerevisiae. Yeast 27(2):89-102 |
SGD |
| GAD1/YMR250W | IMP: Inferred from Mutant Phenotype Assigned on 2002-12-04 |
manually curated | Coleman ST, et al. (2001) Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. J Biol Chem 276(1):244-50 |
SGD |
| GCY1/YOR120W | IGI: Inferred from Genetic Interaction with SGD:GRE3, SGD:YPR1, SGD:YJR096W, SGD:YDL124W Assigned on 2008-05-05 |
manually curated | Chang Q and Petrash JM (2008) Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae. Biochim Biophys Acta 1783(2):237-45 |
SGD |
| GLR1/YPL091W | IMP: Inferred from Mutant Phenotype Assigned on 2002-09-30 |
manually curated | Grant CM, et al. (1996) Stationary-phase induction of GLR1 expression is mediated by the yAP-1 transcriptional regulatory protein in the yeast Saccharomyces cerevisiae. Mol Microbiol 22(4):739-46 |
SGD |
| GND1/YHR183W | IMP: Inferred from Mutant Phenotype Assigned on 2005-01-05 |
manually curated | Izawa S, et al. (1998) Importance of glucose-6-phosphate dehydrogenase in the adaptive response to hydrogen peroxide in Saccharomyces cerevisiae. Biochem J 330 ( Pt 2)():811-7 |
SGD |
| GPX1/YKL026C | IMP: Inferred from Mutant Phenotype Assigned on 2002-09-28 |
manually curated | Avery AM and Avery SV (2001) Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. J Biol Chem 276(36):33730-5 |
SGD |
| GPX2/YBR244W | IMP: Inferred from Mutant Phenotype Assigned on 2002-09-28 |
manually curated | Avery AM and Avery SV (2001) Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. J Biol Chem 276(36):33730-5 |
SGD |
| GRE3/YHR104W | IGI: Inferred from Genetic Interaction with SGD:YPR1, SGD:GCY1, SGD:YJR096W, SGD:YDL124W Assigned on 2008-05-05 |
manually curated | Chang Q and Petrash JM (2008) Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae. Biochim Biophys Acta 1783(2):237-45 |
SGD |
| GRX1/YCL035C | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Luikenhuis S, et al. (1998) The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species. Mol Biol Cell 9(5):1081-91 |
SGD |
| GRX2/YDR513W | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Luikenhuis S, et al. (1998) The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species. Mol Biol Cell 9(5):1081-91 |
SGD |
| GRX3/YDR098C | IMP: Inferred from Mutant Phenotype Assigned on 2007-03-01 |
manually curated | Pujol-Carrion N, et al. (2006) Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae. J Cell Sci 119(Pt 21):4554-64 |
SGD |
| IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Rodriguez-Manzaneque MT, et al. (1999) Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8180-90 |
SGD | |
| GRX4/YER174C | IMP: Inferred from Mutant Phenotype Assigned on 2007-03-01 |
manually curated | Pujol-Carrion N, et al. (2006) Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae. J Cell Sci 119(Pt 21):4554-64 |
SGD |
| IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Rodriguez-Manzaneque MT, et al. (1999) Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8180-90 |
SGD | |
| GRX5/YPL059W | IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Rodriguez-Manzaneque MT, et al. (1999) Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8180-90 |
SGD |
| GRX6/YDL010W | IGI: Inferred from Genetic Interaction with SGD:GRX7, IMP: Inferred from Mutant Phenotype Assigned on 2008-11-14 |
manually curated | Mesecke N, et al. (2008) A Novel Group of Glutaredoxins in the cis-Golgi Critical for Oxidative Stress Resistance. Mol Biol Cell 19(6):2673-80 |
SGD |
| IEP: Inferred from Expression Pattern Assigned on 2008-11-14 |
manually curated | Izquierdo A, et al. (2008) Saccharomyces cerevisiae Grx6 and Grx7 are monothiol glutaredoxins associated with the early secretory pathway. Eukaryot Cell 7(8):1415-26 |
SGD | |
| GRX7/YBR014C | IGI: Inferred from Genetic Interaction with SGD:GRX6 Assigned on 2008-11-14 |
manually curated | Mesecke N, et al. (2008) A Novel Group of Glutaredoxins in the cis-Golgi Critical for Oxidative Stress Resistance. Mol Biol Cell 19(6):2673-80 |
SGD |
| IEP: Inferred from Expression Pattern Assigned on 2008-11-14 |
manually curated | Izquierdo A, et al. (2008) Saccharomyces cerevisiae Grx6 and Grx7 are monothiol glutaredoxins associated with the early secretory pathway. Eukaryot Cell 7(8):1415-26 |
SGD | |
| HCM1/YCR065W | IMP: Inferred from Mutant Phenotype Assigned on 2012-01-06 |
manually curated | Rodriguez-Colman MJ, et al. (2010) The forkhead transcription factor hcm1 promotes mitochondrial biogenesis and stress resistance in yeast. J Biol Chem 285(47):37092-101 |
SGD |
| HSP12/YFL014W | IMP: Inferred from Mutant Phenotype Assigned on 2011-02-14 |
manually curated | Welker S, et al. (2010) Hsp12 Is an Intrinsically Unstructured Stress Protein that Folds upon Membrane Association and Modulates Membrane Function. Mol Cell 39(4):507-520 |
SGD |
| HYR1/YIR037W | IMP: Inferred from Mutant Phenotype Assigned on 2002-09-28 |
manually curated | Avery AM and Avery SV (2001) Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. J Biol Chem 276(36):33730-5 |
SGD |
