Ontology: Cellular Component (GO:0032541)

Definition: A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.

Synonyms: cortical ER; peripheral endoplasmic reticulum; peripheral ER; ER-PM peripheral junction

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term cortical endoplasmic reticulum (16 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	cortical endoplasmic reticulum	16
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term cortical endoplasmic reticulum or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

cortical endoplasmic reticulum      16 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
DPL1/YDR294C	IDA: Inferred from Direct Assay Assigned on 2011-03-30	manually curated	Mukhopadhyay D, et al.  (2008) Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro. J Biol Chem 283(29):20159-69	SGD
FLD1/YLR404W	IDA: Inferred from Direct Assay Assigned on 2008-03-26	manually curated	Fei W, et al.  (2008) Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J Cell Biol 180(3):473-82	SGD
ICE2/YIL090W	IDA: Inferred from Direct Assay Assigned on 2012-10-09	manually curated	Estrada de Martin P, et al.  (2005) Ice2p is important for the distribution and structure of the cortical ER network in Saccharomyces cerevisiae. J Cell Sci 118(Pt 1):65-77	SGD
IST2/YBR086C	IDA: Inferred from Direct Assay Assigned on 2013-02-01	manually curated	Manford AG, et al.  (2012) ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology. Dev Cell 23(6):1129-40	SGD
LCB4/YOR171C	IDA: Inferred from Direct Assay Assigned on 2007-08-23	manually curated	Iwaki S, et al.  (2007) Intracellular Trafficking Pathway of Yeast Long-chain Base Kinase Lcb4, from Its Synthesis to Its Degradation. J Biol Chem 282(39):28485-92	SGD
OSH2/YDL019C	IDA: Inferred from Direct Assay Assigned on 2010-10-21	manually curated	Schulz TA, et al.  (2009) Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. J Cell Biol 187(6):889-903	SGD
OSH3/YHR073W	IDA: Inferred from Direct Assay Assigned on 2010-10-21	manually curated	Schulz TA, et al.  (2009) Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. J Cell Biol 187(6):889-903	SGD
OSH6/YKR003W	IDA: Inferred from Direct Assay Assigned on 2010-10-21	manually curated	Schulz TA, et al.  (2009) Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. J Cell Biol 187(6):889-903	SGD
OSH7/YHR001W	IDA: Inferred from Direct Assay Assigned on 2010-10-21	manually curated	Schulz TA, et al.  (2009) Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. J Cell Biol 187(6):889-903	SGD
RTN1/YDR233C	IDA: Inferred from Direct Assay Assigned on 2008-10-13	manually curated	De Craene JO, et al.  (2006) Rtn1p is involved in structuring the cortical endoplasmic reticulum. Mol Biol Cell 17(7):3009-20	SGD
RTN2/YDL204W	IDA: Inferred from Direct Assay Assigned on 2008-10-13	manually curated	Suda Y, et al.  (2007) Alternative Modes of Organellar Segregation during Sporulation in Saccharomyces cerevisiae. Eukaryot Cell 6(11):2009-17	SGD
SEY1/YOR165W	IDA: Inferred from Direct Assay Assigned on 2009-08-19	manually curated	Hu J, et al.  (2009) A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell 138(3):549-61	SGD
SFH5/YJL145W	IDA: Inferred from Direct Assay Assigned on 2009-06-09	manually curated	Routt SM, et al.  (2005) Nonclassical PITPs activate PLD via the Stt4p PtdIns-4-kinase and modulate function of late stages of exocytosis in vegetative yeast. Traffic 6(12):1157-72	SGD
TCB1/YOR086C	IDA: Inferred from Direct Assay Assigned on 2012-01-23	manually curated	Toulmay A and Prinz WA  (2012) A conserved membrane-binding domain targets proteins to organelle contact sites. J Cell Sci 125(Pt 1):49-58	SGD
TCB2/YNL087W	IDA: Inferred from Direct Assay Assigned on 2012-01-23	manually curated	Toulmay A and Prinz WA  (2012) A conserved membrane-binding domain targets proteins to organelle contact sites. J Cell Sci 125(Pt 1):49-58	SGD
TCB3/YML072C	IDA: Inferred from Direct Assay Assigned on 2012-01-23	manually curated	Toulmay A and Prinz WA  (2012) A conserved membrane-binding domain targets proteins to organelle contact sites. J Cell Sci 125(Pt 1):49-58	SGD
	IDA: Inferred from Direct Assay Assigned on 2013-02-01	manually curated	Manford AG, et al.  (2012) ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology. Dev Cell 23(6):1129-40	SGD

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