Ontology: Cellular Component (GO:0032221)

Definition: A eukaryotically conserved histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species).

Synonyms: Rpd3C(S); Clr6S complex; Clr6 histone deacetylase complex II'

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term Rpd3S complex (5 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	Rpd3S complex	5
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term Rpd3S complex or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

Rpd3S complex      5 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
EAF3/YPR023C	IDA: Inferred from Direct Assay Assigned on 2007-01-04	manually curated	Carrozza MJ, et al.  (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123(4):581-92	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-05-20	manually curated	Keogh MC, et al.  (2005) Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 123(4):593-605	SGD
RCO1/YMR075W	IDA: Inferred from Direct Assay Assigned on 2007-01-04	manually curated	Carrozza MJ, et al.  (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123(4):581-92	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-05-20	manually curated	Keogh MC, et al.  (2005) Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 123(4):593-605	SGD
RPD3/YNL330C	IDA: Inferred from Direct Assay Assigned on 2007-01-04	manually curated	Carrozza MJ, et al.  (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123(4):581-92	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-05-20	manually curated	Keogh MC, et al.  (2005) Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 123(4):593-605	SGD
SIN3/YOL004W	IDA: Inferred from Direct Assay Assigned on 2007-01-04	manually curated	Carrozza MJ, et al.  (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123(4):581-92	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-05-20	manually curated	Keogh MC, et al.  (2005) Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 123(4):593-605	SGD
UME1/YPL139C	IDA: Inferred from Direct Assay Assigned on 2007-01-04	manually curated	Carrozza MJ, et al.  (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123(4):581-92	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-05-20	manually curated	Keogh MC, et al.  (2005) Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 123(4):593-605	SGD

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