Ontology: Biological Process (GO:0031648)

Definition: Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.

Synonyms: negative regulation of protein stability

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term protein destabilization (1 gene) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	protein destabilization	1
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term protein destabilization or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

protein destabilization      1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
SSN3/YPL042C	IMP: Inferred from Mutant Phenotype Assigned on 2011-02-07	manually curated	Nelson C, et al.  (2003) Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12. Nature 421(6919):187-90	SGD

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